{"id":"https://openalex.org/W2002159023","doi":"https://doi.org/10.3109/00365549609049063","title":"Intrathecal Production of Neopterin and \u03b22Microglobulin in Tick-borne Encephalitis (TBE) Compared to Meningoencephalitis of other Etiology","display_name":"Intrathecal Production of Neopterin and \u03b22Microglobulin in Tick-borne Encephalitis (TBE) Compared to Meningoencephalitis of other Etiology","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2002159023","doi":"https://doi.org/10.3109/00365549609049063","mag":"2002159023","pmid":"https://pubmed.ncbi.nlm.nih.gov/8792478"},"language":"en","primary_location":{"id":"doi:10.3109/00365549609049063","doi":"https://doi.org/10.3109/00365549609049063","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365549609049063","pdf_url":null,"source":{"id":"https://openalex.org/S200495913","display_name":"Scandinavian Journal of Infectious Diseases","issn_l":"0036-5548","issn":["0036-5548","1651-1980","2374-4235","2374-4243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111796256","display_name":"G\u00f6ran G\u00fcnther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802208705","display_name":"Danderyds sjukhus","ror":"https://ror.org/00hm9kt34","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2802208705","https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G\u00f6ran G\u00fcnther","raw_affiliation_strings":["Department of Infectious Diseases, Danderyd Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Danderyd Hospital, Sweden","institution_ids":["https://openalex.org/I2802208705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022482611","display_name":"Mats Haglund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mats Haglund","raw_affiliation_strings":["Departments of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083805893","display_name":"Lars Lindquist","orcid":"https://orcid.org/0000-0002-3530-7382","observed_orcids":["https://orcid.org/0000-0002-3530-7382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars Lindquist","raw_affiliation_strings":["Departments of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090604451","display_name":"Birgit Sk\u00f6ldenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802208705","display_name":"Danderyds sjukhus","ror":"https://ror.org/00hm9kt34","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2802208705","https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Birgit Sk\u00f6ldenberg","raw_affiliation_strings":["Department of Infectious Diseases Danderyd Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Danderyd Hospital","institution_ids":["https://openalex.org/I2802208705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015731703","display_name":"Marianne Forsgren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianne Forsgren","raw_affiliation_strings":["Clinical Virology, Huddinge University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Virology, Huddinge University Hospital, Stockholm, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3525,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.54641767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"28","issue":"2","first_page":"131","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.19760000705718994,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tick-borne-encephalitis","display_name":"tick-borne encephalitis","score":1.0},{"id":"https://openalex.org/keywords/neopterin","display_name":"neopterin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8920000195503235},{"id":"https://openalex.org/keywords/aseptic-meningoencephalitis","display_name":"aseptic meningoencephalitis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C2776603314","wikidata":"https://www.wikidata.org/wiki/Q908292","display_name":"Neopterin","level":2,"score":0.9826014041900635},{"id":"https://openalex.org/C2778621254","wikidata":"https://www.wikidata.org/wiki/Q2346415","display_name":"Meningoencephalitis","level":2,"score":0.8829822540283203},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7306937575340271},{"id":"https://openalex.org/C2779404267","wikidata":"https://www.wikidata.org/wiki/Q326663","display_name":"Tick-borne encephalitis","level":4,"score":0.6759488582611084},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6375946402549744},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.634929358959198},{"id":"https://openalex.org/C21957315","wikidata":"https://www.wikidata.org/wiki/Q287896","display_name":"Beta-2 microglobulin","level":2,"score":0.5307310223579407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5240581035614014},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.48084792494773865},{"id":"https://openalex.org/C2781304901","wikidata":"https://www.wikidata.org/wiki/Q4804182","display_name":"Aseptic meningitis","level":3,"score":0.46265846490859985},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4520646035671234},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3893016576766968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37390756607055664},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.07447755336761475},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001613","descriptor_name":"beta 2-Microglobulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001613","descriptor_name":"beta 2-Microglobulin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004675","descriptor_name":"Encephalitis, Tick-Borne","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004675","descriptor_name":"Encephalitis, Tick-Borne","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D004675","descriptor_name":"Encephalitis, Tick-Borne","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004675","descriptor_name":"Encephalitis, Tick-Borne","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D019798","descriptor_name":"Neopterin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00365549609049063","doi":"https://doi.org/10.3109/00365549609049063","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00365549609049063","pdf_url":null,"source":{"id":"https://openalex.org/S200495913","display_name":"Scandinavian Journal of Infectious Diseases","issn_l":"0036-5548","issn":["0036-5548","1651-1980","2374-4235","2374-4243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:8792478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8792478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of infectious diseases","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W143127919","https://openalex.org/W203059533","https://openalex.org/W1520197633","https://openalex.org/W1526027630","https://openalex.org/W1596200575","https://openalex.org/W1819827424","https://openalex.org/W1963280113","https://openalex.org/W1979486202","https://openalex.org/W1998963076","https://openalex.org/W2026780239","https://openalex.org/W2040431122","https://openalex.org/W2043705164","https://openalex.org/W2044026358","https://openalex.org/W2056166047","https://openalex.org/W2086671072","https://openalex.org/W2097246676","https://openalex.org/W2103202047","https://openalex.org/W2108020835","https://openalex.org/W2121034108","https://openalex.org/W2137714198","https://openalex.org/W2149023969","https://openalex.org/W2149684353","https://openalex.org/W2160098369","https://openalex.org/W2165233139","https://openalex.org/W2172402431","https://openalex.org/W2289247164","https://openalex.org/W2404165839","https://openalex.org/W2409922262","https://openalex.org/W2478068498","https://openalex.org/W4313308864","https://openalex.org/W4313309101"],"related_works":["https://openalex.org/W2803620465","https://openalex.org/W2073208133","https://openalex.org/W258960166","https://openalex.org/W2407952276","https://openalex.org/W2410290325","https://openalex.org/W7154797428","https://openalex.org/W4416768919","https://openalex.org/W1983153012","https://openalex.org/W2946615038","https://openalex.org/W2982586220"],"abstract_inverted_index":{"To":[0],"study":[1],"the":[2,8,72,84,117,127,144],"pathophysiology":[3],"of":[4,10,45,129,135,155,175],"tick-borne":[5],"encephalitis":[6],"(TBE),":[7],"kinetics":[9],"neopterin":[11,46,85,136],"and":[12,26,81,94,103,133,137,159],"beta":[13,121,138,163],"2":[14],"microglobulin":[15],"(beta":[16],"2M)":[17],"production":[18,44],"were":[19,56,115],"measured":[20],"in":[21,29,49,54,65,71,90,99,124,178],"sequential,":[22],"cerebrospinal":[23],"fluid":[24],"(CSF)":[25],"serum":[27],"samples":[28],"133":[30],"patients":[31],"with":[32],"aseptic":[33],"meningoencephalitis":[34],"(TBE,":[35],"n":[36,40],"=":[37,41],"72;":[38],"non-TBE,":[39],"61).":[42],"Intrathecal":[43],"was":[47,87,140],"demonstrable":[48],"all":[50],"patients.":[51],"Neopterin":[52,147],"levels":[53,114],"CSF":[55,113,125],"elevated":[57],"already":[58],"at":[59],"day":[60,79],"2:":[61],"geometric":[62],"mean":[63],"value":[64],"TBE":[66,91],"36":[67],"nmol/l":[68,76],"(range":[69],"1-253),":[70],"non-TBE":[73,100],"group":[74],"29":[75],"(0.2-96).":[77],"At":[78],"9":[80],"week":[82],"6":[83],"level":[86],"significantly":[88],"higher":[89],"(86":[92],"(19-725)":[93],"17":[95],"(4-122)":[96],"nmol/l)":[97,106],"than":[98,162],"(28":[101],"(5-109)":[102],"3":[104],"(0.2-58)":[105],"(p":[107],"<":[108],"0.001).":[109],"After":[110],"1":[111],"year":[112],"within":[116],"normal":[118],"range.":[119],"The":[120,131,165],"2M":[122,139],"response":[123,158],"followed":[126],"pattern":[128],"neopterin.":[130],"intensity":[132],"duration":[134],"not":[141],"correlated":[142],"to":[143,149],"clinical":[145],"course.":[146],"seems":[148],"be":[150],"a":[151,169],"more":[152],"sensitive":[153],"indicator":[154],"intrathecal":[156],"T-cell":[157],"inflammatory":[160,172],"reaction":[161,173],"2M.":[164],"results":[166],"indicate":[167],"that":[168],"long-lasting":[170],"strong":[171],"is":[174],"pathophysiological":[176],"significance":[177],"TBE.":[179]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
