{"id":"https://openalex.org/W2002149554","doi":"https://doi.org/10.5812/kowsar.1735143x.733","title":"Ribavirin Impairs Salivary Gland Function in Hepatitis C Patients During Combination Treatment With Pegylated Interferon Alfa-2a","display_name":"Ribavirin Impairs Salivary Gland Function in Hepatitis C Patients During Combination Treatment With Pegylated Interferon Alfa-2a","publication_year":2011,"publication_date":"2011-10-30","ids":{"openalex":"https://openalex.org/W2002149554","doi":"https://doi.org/10.5812/kowsar.1735143x.733","mag":"2002149554","pmid":"https://pubmed.ncbi.nlm.nih.gov/22308157","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3269061"},"language":"en","primary_location":{"id":"doi:10.5812/kowsar.1735143x.733","doi":"https://doi.org/10.5812/kowsar.1735143x.733","is_oa":true,"landing_page_url":"https://doi.org/10.5812/kowsar.1735143x.733","pdf_url":null,"source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5812/kowsar.1735143x.733","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061042436","display_name":"Alessio Aghemo","orcid":"https://orcid.org/0000-0003-0941-3226","observed_orcids":["https://orcid.org/0000-0003-0941-3226"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Aghemo","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca' Granda Hospital, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca' Granda Hospital, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090265285","display_name":"Maria Grazia Rumi","orcid":"https://orcid.org/0000-0002-5876-8528","observed_orcids":["https://orcid.org/0000-0002-5876-8528"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Grazia Rumi","raw_affiliation_strings":["Department of Hepatology, St. Josephs Hospital, University of Milan, mariagrazia.rumi@unimi.it, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, St. Josephs Hospital, University of Milan, mariagrazia.rumi@unimi.it, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004193041","display_name":"Sara Monico","orcid":"https://orcid.org/0000-0001-5359-850X","observed_orcids":["https://orcid.org/0000-0001-5359-850X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Monico","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052037818","display_name":"Matteo Banderali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Banderali","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050660520","display_name":"Antonio Giampiero Russo","orcid":"https://orcid.org/0000-0002-5681-5861","observed_orcids":["https://orcid.org/0000-0002-5681-5861"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Russo","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087504469","display_name":"Francesco Ottaviani","orcid":"https://orcid.org/0000-0002-7862-5663","observed_orcids":["https://orcid.org/0000-0002-7862-5663"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Ottaviani","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016061964","display_name":"Mauro Vigan\u00f2","orcid":"https://orcid.org/0000-0003-0769-1767","observed_orcids":["https://orcid.org/0000-0003-0769-1767"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Vigano","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055005038","display_name":"Roberta D\u2019Ambrosio","orcid":"https://orcid.org/0000-0003-0019-1153","observed_orcids":["https://orcid.org/0000-0003-0019-1153"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta D\u2019Ambrosio","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca\u2019 Granda Hospital, University of Milan, Milan, Italy","A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca\u2019 Granda Hospital, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]},{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033881303","display_name":"Massimo Colombo","orcid":"https://orcid.org/0000-0002-7856-1268","observed_orcids":["https://orcid.org/0000-0002-7856-1268"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Colombo","raw_affiliation_strings":["A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. M. Migliavacca Center for Liver Disease First, Division of Gastroenterology, IRCCS Fondazione Ca Granda Hospital, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090265285"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":null,"apc_paid":null,"fwci":1.9628,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84307052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"11","first_page":"918","last_page":"924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13761","display_name":"HIV/AIDS oral health manifestations","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/xerostomia","display_name":"xerostomia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/salivary-gland-hypofunction","display_name":"salivary gland hypofunction","score":0.9710000157356262},{"id":"https://openalex.org/keywords/peginterferon-alfa-2a","display_name":"peginterferon alfa-2a","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9610000252723694},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/salivary-flow-rate","display_name":"salivary flow rate","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6769999861717224},{"id":"https://openalex.org/keywords/drug-safety-management","display_name":"drug safety management","score":0.33799999952316284},{"id":"https://openalex.org/keywords/patient-education","display_name":"patient education","score":0.3580000102519989},{"id":"https://openalex.org/keywords/health-policy-implications","display_name":"health policy implications","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9263585805892944},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.8161349296569824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7621079683303833},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7399057745933533},{"id":"https://openalex.org/C2776461080","wikidata":"https://www.wikidata.org/wiki/Q7160835","display_name":"Pegylated interferon","level":5,"score":0.6704283356666565},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5318970680236816},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4564604163169861},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4547807276248932},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.25054121017456055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2278449535369873},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.5812/kowsar.1735143x.733","doi":"https://doi.org/10.5812/kowsar.1735143x.733","is_oa":true,"landing_page_url":"https://doi.org/10.5812/kowsar.1735143x.733","pdf_url":null,"source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2279716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3269061","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3269061","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3269061","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepat Mon","raw_type":"Text"},{"id":"pmid:22308157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22308157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis monthly","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5812/kowsar.1735143x.733","doi":"https://doi.org/10.5812/kowsar.1735143x.733","is_oa":true,"landing_page_url":"https://doi.org/10.5812/kowsar.1735143x.733","pdf_url":null,"source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313475","display_name":"Universit\u00e0 degli Studi di Milano","ror":"https://ror.org/00wjc7c48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W84011349","https://openalex.org/W87505188","https://openalex.org/W1517770332","https://openalex.org/W1580727397","https://openalex.org/W1979174109","https://openalex.org/W1981900811","https://openalex.org/W1983154697","https://openalex.org/W1984610449","https://openalex.org/W1992239172","https://openalex.org/W1997514631","https://openalex.org/W2008511662","https://openalex.org/W2011925705","https://openalex.org/W2029323175","https://openalex.org/W2043976325","https://openalex.org/W2063158793","https://openalex.org/W2064546869","https://openalex.org/W2072160870","https://openalex.org/W2094309937","https://openalex.org/W2100797437","https://openalex.org/W2108782509","https://openalex.org/W2114131741","https://openalex.org/W2127685726","https://openalex.org/W2143559032","https://openalex.org/W2163139471","https://openalex.org/W2169631718","https://openalex.org/W4238919719","https://openalex.org/W4244312606","https://openalex.org/W4249894549"],"related_works":["https://openalex.org/W4256544132","https://openalex.org/W7095972147","https://openalex.org/W7097173580","https://openalex.org/W1965945528","https://openalex.org/W2007614406","https://openalex.org/W1991617689","https://openalex.org/W2099653906","https://openalex.org/W335513955","https://openalex.org/W1939494489","https://openalex.org/W7035870786"],"abstract_inverted_index":{":":[0],"Background:":[1],"Xerostomia":[2],"is":[3,257],"a":[4,77,260],"common":[5],"adverse":[6],"event":[7],"of":[8,24,84,117,151,165,188,199,231,240,253,263,267,292],"unknown":[9],"etiology":[10],"observed":[11],"during":[12,26,139],"pegylated":[13],"interferon":[14],"(PegIFN)/Ribavirin":[15],"(Rbv)":[16],"treatment.Objectives:":[17],"To":[18],"assess":[19,82],"the":[20,149,163,186,197,241,250,264,287],"frequency":[21],"and":[22,29,63,69,76,91,109,130,289],"mechanisms":[23],"xerostomia":[25],"PegIFN/Rbv":[27,90,106,140,174,222],"therapy.Patients":[28],"Methods:":[30],"Thirty-one":[31],"na\u00efve":[32],"patients":[33,51,66,88,104,111,220],"with":[34,52],"chronic":[35,53,271],"hepatitis":[36,54,218,272],"C":[37,219,326],"consecutively":[38],"received":[39,57],"PegIFN-\u03b12a":[40,58],"(180":[41,59],"\u03bcg/week)":[42],"plus":[43],"Rbv":[44,212],"(800-1200":[45],"mg/day).":[46],"The":[47,238],"controls":[48],"were":[49,179],"10":[50],"B":[55],"who":[56],"\u03bcg/week).":[60],"During":[61,328],"treatment":[62,141],"follow-up,":[64],"all":[65],"underwent":[67],"basal":[68,128],"masticatory":[70],"stimulated":[71,131],"sialometry,":[72],"otorhinolaryngoiatric":[73],"(ORL)":[74],"examination,":[75],"questionnaire":[78],"survey":[79],"to":[80,181,227,247],"subjectively":[81],"symptoms":[83],"oral":[85],"dryness.Results:":[86],"Twenty-seven":[87],"on":[89,93,105,112],"4":[92],"PegIFN":[94],"(87%":[95],"vs.":[96,122,146,160,190,201],"40%,":[97],"P":[98,124,153,167],"=":[99,168],"0.006)":[100],"reported":[101],"xerostomia.":[102],"Thirty":[103],"combination":[107],"therapy":[108],"2":[110],"monotherapy":[113,210],"had":[114],"ORL":[115],"signs":[116],"salivary":[118,133,176,214],"gland":[119,215],"hypofunction":[120,216],"(97%":[121],"20%,":[123],"<":[125,154],"0.0001).":[126],"Mean":[127],"(A)":[129],"(B)":[132],"flow":[134,177],"rates":[135,178,285],"(mL/min)":[136],"progressively":[137],"decreased":[138],"(A,":[142,183],"0.49":[143,191],"at":[144,148,158,162,185,192,196,203],"baseline":[145,159,182],"0.17":[147],"end":[150,164,187,198],"treatment,":[152,166,175],"0.0001;":[155],"B,":[156,194],"1.24":[157,202],"0.53":[161,184],"0.0004).":[169],"At":[170],"week":[171],"24":[172],"following":[173],"similar":[180],"follow-up":[189,200],"baseline;":[193],"1.19":[195],"baseline).":[204],"Salivary":[205,321],"function":[206],"was":[207],"unaffected":[208],"in":[209,217,324],"patients.Conclusions:":[211],"causes":[213],"receiving":[221],"therapy,":[223],"which":[224],"promptly":[225],"reverts":[226],"normal":[228],"upon":[229],"cessation":[230],"treatment.":[232],"Implication":[233],"for":[234,270,279],"health":[235],"policy/practice/research/medical":[236],"education:":[237],"implications":[239],"present":[242],"study":[243],"can":[244],"be":[245],"useful":[246],"correctly":[248],"manage":[249],"side":[251],"effects":[252],"Ribavirin.":[254],"Indeed":[255],"Ribavirin":[256,319],"not":[258],"only":[259],"key":[261],"player":[262],"current":[265],"standard":[266],"care":[268],"regimen":[269],"C,":[273],"but":[274],"will":[275],"also":[276],"remain":[277],"crucial":[278],"achieving":[280],"optimal":[281],"sustained":[282],"virological":[283],"response":[284],"once":[286],"first":[288],"second":[290],"generation":[291],"directly":[293],"acting":[294],"antiviral":[295],"agents":[296],"become":[297],"available":[298],"worldwide.":[299],"Please":[300],"cite":[301],"this":[302],"paper":[303],"as:":[304],"Aghemo":[305],"A,":[306,314],"Rumi":[307],"MG,":[308],"Monico":[309],"S,":[310],"Banderali":[311],"M,":[312],"Russo":[313],"Ottaviani":[315],"F,":[316],"et":[317],"al.":[318],"Impairs":[320],"Gland":[322],"Function":[323],"Hepatitis":[325],"Patients":[327],"Combination":[329],"Treatment":[330],"With":[331],"Pegylated":[332],"Interferon":[333],"Alfa-2a.":[334],"Hepat":[335],"Mon.":[336],"2011;":[337],"11(11):918-24.DOI:10.5812/kowsar.1735143X.733":[338]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}