{"id":"https://openalex.org/W2002146242","doi":"https://doi.org/10.1053/ejso.2001.1128","title":"New drugs and combinations in the palliative treatment of colon and rectal cancer","display_name":"New drugs and combinations in the palliative treatment of colon and rectal cancer","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2002146242","doi":"https://doi.org/10.1053/ejso.2001.1128","mag":"2002146242","pmid":"https://pubmed.ncbi.nlm.nih.gov/11520095"},"language":"en","primary_location":{"id":"doi:10.1053/ejso.2001.1128","doi":"https://doi.org/10.1053/ejso.2001.1128","is_oa":false,"landing_page_url":"https://doi.org/10.1053/ejso.2001.1128","pdf_url":null,"source":{"id":"https://openalex.org/S158473028","display_name":"European Journal of Surgical Oncology","issn_l":"0748-7983","issn":["0748-7983","1532-2157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Surgical Oncology (EJSO)","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051648139","display_name":"Giordano Domenico Beretta","orcid":"https://orcid.org/0000-0002-8427-7765","observed_orcids":["https://orcid.org/0000-0002-8427-7765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G.D. Beretta","raw_affiliation_strings":["Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089015373","display_name":"Maria Adelaide Pessi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.A. Pessi","raw_affiliation_strings":["Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087679764","display_name":"Paola Lucia Poletti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Poletti","raw_affiliation_strings":["Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037055736","display_name":"Stefania Mosconi","orcid":"https://orcid.org/0000-0002-5919-4992","observed_orcids":["https://orcid.org/0000-0002-5919-4992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Mosconi","raw_affiliation_strings":["Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084773667","display_name":"Roberto Labianca","orcid":"https://orcid.org/0000-0001-7149-822X","observed_orcids":["https://orcid.org/0000-0001-7149-822X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Labianca","raw_affiliation_strings":["Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Ospedali Riuniti Bergamo, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.1662,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.21450617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"6","first_page":"595","last_page":"600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/palliative-chemotherapy","display_name":"palliative chemotherapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/advanced-colorectal-cancer","display_name":"advanced colorectal cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.7549999952316284},{"id":"https://openalex.org/keywords/novel-anticancer-agents","display_name":"novel anticancer agents","score":0.7889999747276306},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9160000085830688},{"id":"https://openalex.org/keywords/symptom-improvement","display_name":"symptom improvement","score":0.746999979019165},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8082375526428223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6978709697723389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4953254759311676},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39806342124938965},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37663185596466064},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3305876851081848}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010166","descriptor_name":"Palliative Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017671","descriptor_name":"Platinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1053/ejso.2001.1128","doi":"https://doi.org/10.1053/ejso.2001.1128","is_oa":false,"landing_page_url":"https://doi.org/10.1053/ejso.2001.1128","pdf_url":null,"source":{"id":"https://openalex.org/S158473028","display_name":"European Journal of Surgical Oncology","issn_l":"0748-7983","issn":["0748-7983","1532-2157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Surgical Oncology (EJSO)","raw_type":"journal-article"},{"id":"pmid:11520095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11520095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1580716972","https://openalex.org/W1811602282","https://openalex.org/W1847455118","https://openalex.org/W1929570960","https://openalex.org/W1969825132","https://openalex.org/W2006824814","https://openalex.org/W2030175426","https://openalex.org/W2042418351","https://openalex.org/W2056131235","https://openalex.org/W2096122707","https://openalex.org/W2109558652","https://openalex.org/W2119270435","https://openalex.org/W2128447158","https://openalex.org/W2141121384","https://openalex.org/W2162313061","https://openalex.org/W2171680834","https://openalex.org/W2181829339","https://openalex.org/W2309097152","https://openalex.org/W2396646859","https://openalex.org/W2408955754","https://openalex.org/W2411068603","https://openalex.org/W2602544133","https://openalex.org/W4246299175"],"related_works":["https://openalex.org/W2059072558","https://openalex.org/W2031740143","https://openalex.org/W2141311805","https://openalex.org/W2356573340","https://openalex.org/W1965051260","https://openalex.org/W131030860","https://openalex.org/W22419424","https://openalex.org/W2043357510","https://openalex.org/W4240559148","https://openalex.org/W4246183758"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}