{"id":"https://openalex.org/W2002145735","doi":"https://doi.org/10.1016/0009-2797(78)90048-0","title":"Circular dichroism studies on the binding of Type I substrates and reverse Type I compounds to rabbit liver microsomal cytochrome P-450","display_name":"Circular dichroism studies on the binding of Type I substrates and reverse Type I compounds to rabbit liver microsomal cytochrome P-450","publication_year":1978,"publication_date":"1978-02-01","ids":{"openalex":"https://openalex.org/W2002145735","doi":"https://doi.org/10.1016/0009-2797(78)90048-0","mag":"2002145735","pmid":"https://pubmed.ncbi.nlm.nih.gov/25718"},"language":"en","primary_location":{"id":"doi:10.1016/0009-2797(78)90048-0","doi":"https://doi.org/10.1016/0009-2797(78)90048-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0009-2797(78)90048-0","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002507714","display_name":"Hitoshi Shichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hitoshi Shichi","raw_affiliation_strings":["Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Md 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vision Research, National Eye Institute, National Institutes of Health, Bethesda, Md 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037017075","display_name":"Kenji Kumaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenji Kumaki","raw_affiliation_strings":["Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029237881","display_name":"Daniel W. Nebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel W. Nebert","raw_affiliation_strings":["Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":1.9457,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83673469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"2","first_page":"133","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9810000061988831},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cyclohexane","display_name":"cyclohexane","score":0.8930000066757202},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-hydroxylase","display_name":"aryl hydrocarbon hydroxylase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.8309999704360962},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.984000027179718},{"id":"https://openalex.org/keywords/mixed-function-oxidase","display_name":"mixed function oxidase","score":0.5580000281333923},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.5920000076293945},{"id":"https://openalex.org/keywords/high-spin-states","display_name":"high-spin states","score":0.42100000381469727},{"id":"https://openalex.org/keywords/aliphatic-chain-length","display_name":"aliphatic chain length","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.8801541328430176},{"id":"https://openalex.org/C2778237882","wikidata":"https://www.wikidata.org/wiki/Q211433","display_name":"Cyclohexane","level":2,"score":0.8310070037841797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7894026041030884},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.7292358875274658},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.723558247089386},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5931055545806885},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5766083002090454},{"id":"https://openalex.org/C2780303067","wikidata":"https://www.wikidata.org/wiki/Q223099","display_name":"Methylcholanthrene","level":3,"score":0.4858086109161377},{"id":"https://openalex.org/C2777713963","wikidata":"https://www.wikidata.org/wiki/Q663902","display_name":"Butanol","level":3,"score":0.44678157567977905},{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.41402655839920044},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3312283158302307},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3273351788520813},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.32489335536956787},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.2648451328277588},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.24734026193618774},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2131521999835968},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19038715958595276},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06680354475975037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05913427472114563}],"mesh":[{"descriptor_ui":"D000438","descriptor_name":"Alcohols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008748","descriptor_name":"Methylcholanthrene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0009-2797(78)90048-0","doi":"https://doi.org/10.1016/0009-2797(78)90048-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0009-2797(78)90048-0","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:25718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W142386677","https://openalex.org/W1483640295","https://openalex.org/W1497467960","https://openalex.org/W1498048579","https://openalex.org/W1515756335","https://openalex.org/W1516077580","https://openalex.org/W1542420067","https://openalex.org/W1542877165","https://openalex.org/W1549176069","https://openalex.org/W1570847980","https://openalex.org/W1576233898","https://openalex.org/W1591874105","https://openalex.org/W1598290663","https://openalex.org/W1775749144","https://openalex.org/W1775964807","https://openalex.org/W1793982695","https://openalex.org/W1951469402","https://openalex.org/W1956759182","https://openalex.org/W1964883950","https://openalex.org/W1968833927","https://openalex.org/W1972166860","https://openalex.org/W1972460037","https://openalex.org/W1982386536","https://openalex.org/W1989852001","https://openalex.org/W2005796859","https://openalex.org/W2008240360","https://openalex.org/W2010398865","https://openalex.org/W2029385650","https://openalex.org/W2040746199","https://openalex.org/W2041896131","https://openalex.org/W2046064955","https://openalex.org/W2053353249","https://openalex.org/W2057355667","https://openalex.org/W2062228103","https://openalex.org/W2067917957","https://openalex.org/W2089967565","https://openalex.org/W2102259249","https://openalex.org/W2112236562","https://openalex.org/W2112622460","https://openalex.org/W2335048755","https://openalex.org/W2406377496","https://openalex.org/W2409721662","https://openalex.org/W2411544389","https://openalex.org/W2415844257","https://openalex.org/W2488170970","https://openalex.org/W4406987760","https://openalex.org/W6732424700"],"related_works":["https://openalex.org/W2070279779","https://openalex.org/W2138377206","https://openalex.org/W2005796859","https://openalex.org/W1608262032","https://openalex.org/W1964883950","https://openalex.org/W2320727916","https://openalex.org/W1991430035","https://openalex.org/W2026929914","https://openalex.org/W2168626592","https://openalex.org/W2069278195"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
