{"id":"https://openalex.org/W2002136893","doi":"https://doi.org/10.1016/j.bbagen.2014.01.018","title":"Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases","display_name":"Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases","publication_year":2014,"publication_date":"2014-01-18","ids":{"openalex":"https://openalex.org/W2002136893","doi":"https://doi.org/10.1016/j.bbagen.2014.01.018","mag":"2002136893","pmid":"https://pubmed.ncbi.nlm.nih.gov/24447566"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbagen.2014.01.018","doi":"https://doi.org/10.1016/j.bbagen.2014.01.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbagen.2014.01.018","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077200521","display_name":"Hooi Ching Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hooi Ching Lim","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051382096","display_name":"John Couchman","orcid":"https://orcid.org/0000-0003-3409-7093","observed_orcids":["https://orcid.org/0000-0003-3409-7093"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"John R. Couchman","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address: john.couchman@bric.ku.dk","Department of Biomedical Sciences, University of Copenhagen , Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address: john.couchman@bric.ku.dk","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen , Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051382096"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":3310,"currency":"USD","value_usd":3310},"apc_paid":null,"fwci":2.7679,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.89573607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"1840","issue":"8","first_page":"2482","last_page":"2490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syndecan-2","display_name":"syndecan-2","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9369999766349792},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rhoc","display_name":"RhoC","score":0.9789999723434448},{"id":"https://openalex.org/keywords/p190rhogap","display_name":"p190RhoGAP","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.8019999861717224},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.7699999809265137},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/syndecan-4","display_name":"syndecan-4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6000000238418579},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C65001120","wikidata":"https://www.wikidata.org/wiki/Q14912913","display_name":"Syndecan 1","level":3,"score":0.7419499754905701},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.5352751612663269},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.534318745136261},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4312417209148407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40171393752098083},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3939383924007416},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3631414473056793},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.33625784516334534},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2936829626560211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28564703464508057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2507024109363556},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19650152325630188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12165406346321106}],"mesh":[{"descriptor_ui":"D000075024","descriptor_name":"rhoC GTP-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053669","descriptor_name":"Syndecan-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053671","descriptor_name":"Syndecan-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbagen.2014.01.018","doi":"https://doi.org/10.1016/j.bbagen.2014.01.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbagen.2014.01.018","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},{"id":"pmid:24447566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24447566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/f0f82adc-9de1-474a-8ceb-fec0e0f45c76","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/f0f82adc-9de1-474a-8ceb-fec0e0f45c76","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lim, H C & Couchman, J R 2014, 'Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases', BBA General Subjects, vol. 1840, no. 8, pp. 2482\u20132490. https://doi.org/10.1016/j.bbagen.2014.01.018","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G554895933","display_name":null,"funder_award_id":"NNF11OC1015449","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320320943","display_name":"Danmarks Grundforskningsfond","ror":"https://ror.org/00znyv691"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W150636694","https://openalex.org/W1949238489","https://openalex.org/W1963209155","https://openalex.org/W1965734619","https://openalex.org/W1966633908","https://openalex.org/W1968431556","https://openalex.org/W1975796762","https://openalex.org/W1979346765","https://openalex.org/W1980506609","https://openalex.org/W1988176449","https://openalex.org/W1998715260","https://openalex.org/W2007660746","https://openalex.org/W2008869013","https://openalex.org/W2026260372","https://openalex.org/W2029529001","https://openalex.org/W2031686407","https://openalex.org/W2045434041","https://openalex.org/W2053902089","https://openalex.org/W2054280794","https://openalex.org/W2055491388","https://openalex.org/W2057179778","https://openalex.org/W2061600983","https://openalex.org/W2068316985","https://openalex.org/W2077603983","https://openalex.org/W2079013149","https://openalex.org/W2080151197","https://openalex.org/W2080489322","https://openalex.org/W2083514445","https://openalex.org/W2091163220","https://openalex.org/W2091849418","https://openalex.org/W2094248719","https://openalex.org/W2097376134","https://openalex.org/W2103048323","https://openalex.org/W2105499419","https://openalex.org/W2113633302","https://openalex.org/W2115517429","https://openalex.org/W2122716387","https://openalex.org/W2134807132","https://openalex.org/W2144588996","https://openalex.org/W2150125913","https://openalex.org/W2150346488","https://openalex.org/W2154931831","https://openalex.org/W2155917588","https://openalex.org/W2408693896"],"related_works":["https://openalex.org/W1967495565","https://openalex.org/W2324318858","https://openalex.org/W3170183626","https://openalex.org/W2166171496","https://openalex.org/W2055491388","https://openalex.org/W2087307762","https://openalex.org/W39938555","https://openalex.org/W3017204060","https://openalex.org/W2013216256","https://openalex.org/W2061858190"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}