{"id":"https://openalex.org/W2002134229","doi":"https://doi.org/10.1677/joe.0.0460453","title":"STUDIES ON THE BIOSYNTHESIS OF ALDOSTERONE USING THE SHEEP ADRENAL TRANSPLANT: EFFECT OF SODIUM DEPLETION ON THE CONVERSION OF CORTICOSTERONE TO ALDOSTERONE","display_name":"STUDIES ON THE BIOSYNTHESIS OF ALDOSTERONE USING THE SHEEP ADRENAL TRANSPLANT: EFFECT OF SODIUM DEPLETION ON THE CONVERSION OF CORTICOSTERONE TO ALDOSTERONE","publication_year":1970,"publication_date":"1970-04-01","ids":{"openalex":"https://openalex.org/W2002134229","doi":"https://doi.org/10.1677/joe.0.0460453","mag":"2002134229","pmid":"https://pubmed.ncbi.nlm.nih.gov/5443188"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.0460453","doi":"https://doi.org/10.1677/joe.0.0460453","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.0460453","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112788969","display_name":"John R. Blair-West","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. R. BLAIR-WEST","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. BRODIE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. BRODIE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112051238","display_name":"John P. Coghlan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. P. COGHLAN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025617950","display_name":"Derek A. Denton","orcid":"https://orcid.org/0000-0002-1931-1365","observed_orcids":["https://orcid.org/0000-0002-1931-1365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. A. DENTON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037640308","display_name":"C. Flood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. FLOOD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108401982","display_name":"JAMES R. GODING","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. R. GODING","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113594726","display_name":"B. A. Scoggins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. A. SCOGGINS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111494824","display_name":"James Francis Tait","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. F. TAIT","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112143046","display_name":"Sylvia A. S. Tait","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. A. S. TAIT","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111823013","display_name":"E. Marelyn Wintour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E M. WINTOUR","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013177497","display_name":"R. DOUGLAS WRIGHT","orcid":"https://orcid.org/0000-0002-1317-8073","observed_orcids":["https://orcid.org/0000-0002-1317-8073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. D. WRIGHT","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9074,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.9438485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"46","issue":"4","first_page":"453","last_page":"476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldosterone-biosynthesis","display_name":"aldosterone biosynthesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sodium-depletion","display_name":"sodium depletion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.4560000002384186},{"id":"https://openalex.org/keywords/aldosterone-secretion","display_name":"aldosterone secretion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/parotid-fistula","display_name":"parotid fistula","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.9760873317718506},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.8612749576568604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8181451559066772},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8114483952522278},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5815621018409729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5356813073158264},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.41538673639297485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2735442519187927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2549107074737549},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1459195613861084},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007601","descriptor_name":"Jugular Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010306","descriptor_name":"Parotid Gland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1677/joe.0.0460453","doi":"https://doi.org/10.1677/joe.0.0460453","is_oa":false,"landing_page_url":"https://doi.org/10.1677/joe.0.0460453","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:5443188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5443188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049913826","https://openalex.org/W2067883188","https://openalex.org/W2112477277","https://openalex.org/W1994334899","https://openalex.org/W2034376647","https://openalex.org/W2107675391","https://openalex.org/W2086319818","https://openalex.org/W2067170942","https://openalex.org/W2066497858","https://openalex.org/W2143071809"],"abstract_inverted_index":{"SUMMARY":[0],"The":[1,60,170,237],"effect":[2],"of":[3,9,22,41,62,70,87,93,102,105,113,126,144,157,173,201,220,239,244,249],"sodium":[4,150,167,189,193],"depletion":[5],"on":[6],"the":[7,19,31,35,45,52,67,84,88,103,122,129,132,166,174,179,192,199,205,209,213,218,224,229,240,245,250],"conversion":[8,61,92,135,160],"corticosterone":[10],"to":[11,64,162,234],"aldosterone":[12,71,89,96,138,154,175],"has":[13],"been":[14],"examined":[15],"in":[16,55,74,165,212,247],"vivo":[17],"using":[18,77],"adrenal":[20,32,47],"transplants":[21],"two":[23],"sheep.":[24],"[3H]Corticosterone":[25],"was":[26,49,72,118,176,208],"infused":[27],"continuously":[28],"directly":[29],"into":[30],"gland":[33],"via":[34,51],"carotid":[36],"artery":[37],"over":[38,110,141],"a":[39,78,111,142,202,221],"period":[40,112],"30":[42],"min.":[43,101,115,125],"and":[44,66,83,107,242],"total":[46],"effluent":[48],"collected":[50],"jugular":[53],"vein":[54],"six":[56],"consecutive":[57],"5-min.":[58],"samples.":[59],"[3H]corticosterone":[63],"[3H]aldosterone":[65],"endogenous":[68],"output":[69],"measured":[73],"each":[75],"sample":[76],"double":[79],"isotope":[80],"derivative":[81],"method":[82],"specific":[85,171,206,225],"activity":[86,172,207,226],"calculated.":[90],"Radioactive":[91],"B":[94],"\u2192":[95],"reached":[97],"equilibrium":[98],"within":[99],"10":[100],"start":[104],"infusion":[106],"remained":[108],"constant":[109,120,177],"10\u201325":[114],"Aldosterone":[116],"secretion":[117,139,155,230],"also":[119],"during":[121],"first":[123],"25":[124],"infusion.":[127],"In":[128,191],"same":[130,210],"sheep":[131],"mean":[133],"percentage":[134],"increased":[136,227],"as":[137,211,228],"rose":[140],"range":[143,182,195],"2\u201312":[145],"\u03bcg./hr.":[146],"With":[147],"more":[148],"severe":[149,188],"depletion,":[151],"i.e.":[152],"with":[153,187],"rates":[156],"12\u201316":[158],"\u03bcg./hr.,":[159],"decreased":[161,231],"that":[163],"found":[164],"replete":[168,194],"state.":[169,216],"throughout":[178],"mildly":[180,214],"deplete":[181,215],"(2\u201312":[183],"\u03bcg./hr.)":[184,197],"but":[185],"fell":[186],"depletion.":[190],"(0\u20132":[196],"before":[198],"introduction":[200,219],"parotid":[203,222],"fistula,":[204],"After":[217],"fistula":[223],"from":[232],"2":[233],"0":[235],"\u03bcg.":[236],"validity":[238],"approach":[241],"interpretation":[243],"results":[246],"terms":[248],"biosynthetic":[251],"pathways":[252],"involved":[253],"are":[254],"discussed.":[255]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}