{"id":"https://openalex.org/W2002134090","doi":"https://doi.org/10.1371/journal.pone.0001031","title":"Wnt and TGF-\u03b2 Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning","display_name":"Wnt and TGF-\u03b2 Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning","publication_year":2007,"publication_date":"2007-10-10","ids":{"openalex":"https://openalex.org/W2002134090","doi":"https://doi.org/10.1371/journal.pone.0001031","mag":"2002134090","pmid":"https://pubmed.ncbi.nlm.nih.gov/17925879","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2000352"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0001031","doi":"https://doi.org/10.1371/journal.pone.0001031","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001031","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001031&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001031&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050536765","display_name":"Maja Adamska","orcid":"https://orcid.org/0000-0002-4223-8450","observed_orcids":["https://orcid.org/0000-0002-4223-8450"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Maja Adamska","raw_affiliation_strings":["School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000765256","display_name":"Bernard M. Degnan","orcid":"https://orcid.org/0000-0001-7573-8518","observed_orcids":["https://orcid.org/0000-0001-7573-8518","https://orcid.org/0000-0001-8003-0426"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sandie M. Degnan","raw_affiliation_strings":["School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074270180","display_name":"Kathryn Green","orcid":"https://orcid.org/0000-0002-9641-2442","observed_orcids":["https://orcid.org/0000-0002-9641-2442"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn M. Green","raw_affiliation_strings":["School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102800319","display_name":"Marcin Adamski","orcid":"https://orcid.org/0000-0002-1703-6742","observed_orcids":["https://orcid.org/0000-0002-1703-6742"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marcin Adamski","raw_affiliation_strings":["School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047276490","display_name":"Alina Craigie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alina Craigie","raw_affiliation_strings":["School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085065413","display_name":"Claire Larroux","orcid":"https://orcid.org/0000-0002-3503-4150","observed_orcids":["https://orcid.org/0000-0002-3503-4150"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Claire Larroux","raw_affiliation_strings":["School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000765256","display_name":"Bernard M. Degnan","orcid":"https://orcid.org/0000-0001-7573-8518","observed_orcids":["https://orcid.org/0000-0001-7573-8518","https://orcid.org/0000-0001-8003-0426"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Bernard M. Degnan","raw_affiliation_strings":["School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Integrative Biology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000765256"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":44.6867,"has_fulltext":true,"cited_by_count":255,"citation_normalized_percentile":{"value":0.99977065,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"2","issue":"10","first_page":"e1031","last_page":"e1031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.4968000054359436,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.4968000054359436,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amphimedon-queenslandica","display_name":"Amphimedon queenslandica","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anteroposterior-axis","display_name":"anterior-posterior axis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/axial-polarity","display_name":"axial polarity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/gene-expression-patterns","display_name":"gene expression patterns","score":0.5979999899864197},{"id":"https://openalex.org/keywords/sponges","display_name":"sponges","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8550431132316589},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8057873249053955},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.7934522032737732},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5421865582466125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45278921723365784},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4514826238155365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44019803404808044},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43606990575790405},{"id":"https://openalex.org/C197583594","wikidata":"https://www.wikidata.org/wiki/Q1052390","display_name":"Most recent common ancestor","level":4,"score":0.41304725408554077},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37900885939598083},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.35903334617614746},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3326507806777954},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.09940895438194275}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0001031","doi":"https://doi.org/10.1371/journal.pone.0001031","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001031","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001031&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2000352","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2000352","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:17925879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17925879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1627337","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1627337","pdf_url":"https://www.osti.gov/servlets/purl/1627337","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.7839","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.7839","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/68/1b/PLoS_ONE_2007_Oct_10_2(10)_e1031.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9f9db22683c74ed89f5eb9356f9561f3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9f9db22683c74ed89f5eb9356f9561f3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 2, Iss 10, p e1031 (2007)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/151558","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Wnt_and_TGF_Expression_in_the_Sponge_Amphimedon_queenslandica_and_the_Origin_of_Metazoan_Embryonic_Patterning/151558","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0001031","doi":"https://doi.org/10.1371/journal.pone.0001031","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001031","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001031&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320316170","display_name":"Joint Genome Institute","ror":"https://ror.org/04xm1d337"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002134090.pdf","grobid_xml":"https://content.openalex.org/works/W2002134090.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W614012683","https://openalex.org/W1481927008","https://openalex.org/W1501777420","https://openalex.org/W1533376056","https://openalex.org/W1541821200","https://openalex.org/W1551008045","https://openalex.org/W1634598038","https://openalex.org/W1656357824","https://openalex.org/W1776986321","https://openalex.org/W1970186672","https://openalex.org/W1976785417","https://openalex.org/W1988011675","https://openalex.org/W1988966899","https://openalex.org/W1996867583","https://openalex.org/W1998231969","https://openalex.org/W1998300637","https://openalex.org/W2009379859","https://openalex.org/W2013204587","https://openalex.org/W2016022693","https://openalex.org/W2016877612","https://openalex.org/W2022513916","https://openalex.org/W2028169893","https://openalex.org/W2039282080","https://openalex.org/W2043377295","https://openalex.org/W2056968521","https://openalex.org/W2060034125","https://openalex.org/W2068478374","https://openalex.org/W2073514647","https://openalex.org/W2077908307","https://openalex.org/W2079236594","https://openalex.org/W2083438848","https://openalex.org/W2083663680","https://openalex.org/W2087526418","https://openalex.org/W2091821419","https://openalex.org/W2107599800","https://openalex.org/W2110339205","https://openalex.org/W2111333753","https://openalex.org/W2114395497","https://openalex.org/W2116390604","https://openalex.org/W2123039189","https://openalex.org/W2124965282","https://openalex.org/W2141015786","https://openalex.org/W2155603123","https://openalex.org/W2165511961","https://openalex.org/W2168905766","https://openalex.org/W2186081087","https://openalex.org/W4211089574","https://openalex.org/W6856561178"],"related_works":["https://openalex.org/W6988092102","https://openalex.org/W1605394511","https://openalex.org/W2049189105","https://openalex.org/W7098796316","https://openalex.org/W2988263874","https://openalex.org/W115316481","https://openalex.org/W4206888837","https://openalex.org/W2001489844","https://openalex.org/W2013204587","https://openalex.org/W5026074"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,264],"origin":[2],"of":[3,13,22,24,36,79,91,133,197,200,229,255,269,277],"metazoan":[4,123],"development":[5,43,90,136,193],"and":[6,17,48,73,83,114,161,186,214,231,244,262,271,280],"differentiation":[7],"was":[8],"contingent":[9],"upon":[10],"the":[11,25,55,60,66,77,88,100,130,142,145,158,166,177,195,208,220,227,236,249,253,274,293],"evolution":[12],"cell":[14,27],"adhesion,":[15],"communication":[16],"cooperation":[18],"mechanisms.":[19],"While":[20],"components":[21],"many":[23],"major":[26],"signalling":[28,62,85,116,285],"pathways":[29,286],"have":[30,44,109],"been":[31,46],"identified":[32],"in":[33,42,65,99,121,137,181,192,233,292],"a":[34,92,198,204],"range":[35],"sponges":[37,72],"(phylum":[38],"Porifera),":[39],"their":[40],"roles":[41],"not":[45],"investigated":[47],"remain":[49],"largely":[50],"unknown.":[51],"Here,":[52],"we":[53,108],"take":[54],"first":[56,295],"steps":[57],"toward":[58],"reconstructing":[59],"developmental":[61],"systems":[63],"used":[64],"last":[67],"common":[68],"ancestor":[69,237],"to":[70,149,157,241,251,288],"living":[71],"eumetazoans":[74],"by":[75],"studying":[76],"expression":[78,154,163,173,188,228,267],"genes":[80,111,126],"encoding":[81,112],"Wnt":[82,113,153,185,213,230,270],"TGF-beta":[84,115,172,187,215,232,272],"ligands":[86,117],"during":[87,194],"embryonic":[89,135],"sponge.":[93],"METHODOLOGY/PRINCIPAL":[94],"FINDINGS:":[95],"Using":[96],"resources":[97],"generated":[98],"recent":[101],"sponge":[102,184,278],"Amphimedon":[103,134,146,234],"queenslandica":[104],"(Demospongiae)":[105],"genome":[106],"project,":[107],"recovered":[110],"that":[118,202,235,238,283],"are":[119,127,216],"critical":[120],"patterning":[122,196],"embryos.":[124],"Both":[125],"expressed":[128,217],"from":[129,226],"earliest":[131],"stages":[132],"highly":[138],"dynamic":[139],"patterns.":[140],"At":[141],"time":[143],"when":[144],"embryos":[147,279],"begin":[148],"display":[150],"anterior-posterior":[151,221,275],"polarity,":[152],"becomes":[155],"localised":[156],"posterior":[159],"pole":[160],"this":[162],"continues":[164],"until":[165],"swimming":[167],"larva":[168],"stage.":[169],"In":[170],"contrast,":[171],"is":[174],"highest":[175],"at":[176],"anterior":[178],"pole.":[179],"As":[180],"complex":[182],"animals,":[183],"patterns":[189,268],"intersect":[190],"later":[191],"sub-community":[199],"cells":[201],"form":[203],"simple":[205],"tissue-like":[206],"structure,":[207],"pigment":[209],"ring.":[210],"Throughout":[211],"development,":[212],"radially":[218,265],"along":[219,273],"axis.":[222],"CONCLUSIONS/SIGNIFICANCE:":[223],"We":[224],"infer":[225],"gave":[239],"rise":[240],"sponges,":[242],"cnidarians":[243],"bilaterians":[245],"had":[246],"already":[247],"evolved":[248],"capacity":[250],"direct":[252],"formation":[254],"relatively":[256],"sophisticated":[257],"body":[258],"plans,":[259],"with":[260],"axes":[261],"tissues.":[263],"symmetrical":[266],"axis":[276],"larvae":[281],"suggest":[282],"these":[284],"contributed":[287],"establishing":[289],"axial":[290],"polarity":[291],"very":[294],"metazoans.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}