{"id":"https://openalex.org/W2002124496","doi":"https://doi.org/10.1126/science.1117806","title":"The Functional Genomics of Noncoding RNA","display_name":"The Functional Genomics of Noncoding RNA","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2002124496","doi":"https://doi.org/10.1126/science.1117806","mag":"2002124496","pmid":"https://pubmed.ncbi.nlm.nih.gov/16141063"},"language":"en","primary_location":{"id":"doi:10.1126/science.1117806","doi":"https://doi.org/10.1126/science.1117806","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1117806","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2002124496"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023828670","display_name":"John S. Mattick","orcid":"https://orcid.org/0000-0002-7680-7527","observed_orcids":["https://orcid.org/0000-0002-7680-7527"]},"institutions":[{"id":"https://openalex.org/I1337719021","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86","country_code":"AU","type":"government","lineage":["https://openalex.org/I1337719021","https://openalex.org/I2801453606","https://openalex.org/I4210132349"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"John S. Mattick","raw_affiliation_strings":["Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I1337719021","https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023828670"],"corresponding_institution_ids":["https://openalex.org/I1337719021","https://openalex.org/I165143802","https://openalex.org/I4405277047"],"apc_list":null,"apc_paid":null,"fwci":10.8892,"has_fulltext":false,"cited_by_count":300,"citation_normalized_percentile":{"value":0.98980466,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"309","issue":"5740","first_page":"1527","last_page":"1528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"functional genomics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nfat","display_name":"NFAT","score":0.5870000123977661},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7050055265426636},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.6822556257247925},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6166179776191711},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5899925231933594},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5878543853759766},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.5789729356765747},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5698400139808655},{"id":"https://openalex.org/C119401833","wikidata":"https://www.wikidata.org/wiki/Q7802158","display_name":"Tiling array","level":5,"score":0.5623729825019836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5418766736984253},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5012900829315186},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.44304850697517395},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32516661286354065},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.27005326747894287}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D028961","descriptor_name":"beta Karyopherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.1117806","doi":"https://doi.org/10.1126/science.1117806","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1117806","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:16141063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16141063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Comment"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.843.699","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.843.699","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://science.sciencemag.org/content/sci/309/5740/1527.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W151786846","https://openalex.org/W1531414226","https://openalex.org/W1686333409","https://openalex.org/W1986234964","https://openalex.org/W1990261634","https://openalex.org/W2018507242","https://openalex.org/W2030120875","https://openalex.org/W2053833990","https://openalex.org/W2060434878","https://openalex.org/W2078153372","https://openalex.org/W2090822519","https://openalex.org/W2099468911","https://openalex.org/W2106554405","https://openalex.org/W2110056878","https://openalex.org/W2113028064","https://openalex.org/W2114112529","https://openalex.org/W2115441328","https://openalex.org/W2134268015","https://openalex.org/W2136725005","https://openalex.org/W2165764599","https://openalex.org/W2166967514","https://openalex.org/W2187417714"],"related_works":["https://openalex.org/W2097688636","https://openalex.org/W2166967514","https://openalex.org/W2093807013","https://openalex.org/W4252225370","https://openalex.org/W1507925089","https://openalex.org/W2801532602","https://openalex.org/W2030047242","https://openalex.org/W1542426682","https://openalex.org/W4411085170"],"abstract_inverted_index":{"Large":[0],"numbers":[1],"of":[2,53,70,85,93],"noncoding":[3],"RNA":[4,58],"transcripts":[5,32],"(ncRNAs)":[6],"are":[7,33],"being":[8],"revealed":[9],"by":[10,37,45],"complementary":[11],"DNA":[12],"cloning":[13],"and":[14,23],"genome":[15],"tiling":[16],"array":[17],"studies":[18],"in":[19,60,88,98],"animals.":[20],"The":[21],"big":[22],"as":[24],"yet":[25],"largely":[26],"unanswered":[27],"question":[28],"is":[29],"whether":[30],"these":[31],"relevant.":[34],"A":[35],"paper":[36],"Willingham":[38],"et":[39],"al.":[40],"shows":[41],"the":[42,71,91],"way":[43],"forward":[44],"developing":[46],"a":[47,65,81],"strategy":[48],"for":[49],"large-scale":[50],"functional":[51,99],"screening":[52],"ncRNAs,":[54],"involving":[55],"small":[56],"interfering":[57],"knockdowns":[59],"cell-based":[61],"screens,":[62],"which":[63,94],"identified":[64],"previously":[66],"unidentified":[67],"ncRNA":[68],"repressor":[69],"transcription":[72],"factor":[73],"NFAT.":[74],"It":[75],"appears":[76],"likely":[77],"that":[78],"ncRNAs":[79],"constitute":[80],"critical":[82],"hidden":[83],"layer":[84],"gene":[86],"regulation":[87],"complex":[89],"organisms,":[90],"understanding":[92],"requires":[95],"new":[96],"approaches":[97],"genomics.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}