{"id":"https://openalex.org/W2002121944","doi":"https://doi.org/10.1158/1078-0432.ccr-12-2293","title":"The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models","display_name":"The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models","publication_year":2013,"publication_date":"2013-02-23","ids":{"openalex":"https://openalex.org/W2002121944","doi":"https://doi.org/10.1158/1078-0432.ccr-12-2293","mag":"2002121944","pmid":"https://pubmed.ncbi.nlm.nih.gov/23434734"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-12-2293","doi":"https://doi.org/10.1158/1078-0432.ccr-12-2293","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-2293","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052120219","display_name":"Ymera Pignochino","orcid":"https://orcid.org/0000-0001-5073-8618","observed_orcids":["https://orcid.org/0000-0001-5073-8618"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Ymera Pignochino","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086229991","display_name":"Carmine Dell\u2019Aglio","orcid":"https://orcid.org/0000-0003-2089-1077","observed_orcids":["https://orcid.org/0000-0003-2089-1077"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmine Dell'Aglio","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079227239","display_name":"Marco Basiric\u00f2","orcid":"https://orcid.org/0000-0002-3059-7501","observed_orcids":["https://orcid.org/0000-0002-3059-7501"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Basiric\u00f2","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027747604","display_name":"Federica Capozzi","orcid":"https://orcid.org/0000-0002-6458-5699","observed_orcids":["https://orcid.org/0000-0002-6458-5699"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Capozzi","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086215437","display_name":"Marco Soster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Soster","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009087591","display_name":"Serena Marchi\u00f2","orcid":"https://orcid.org/0000-0001-8214-0776","observed_orcids":["https://orcid.org/0000-0001-8214-0776"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Marchi\u00f2","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049670577","display_name":"Stefania Bruno","orcid":"https://orcid.org/0000-0002-8879-9536","observed_orcids":["https://orcid.org/0000-0002-8879-9536"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Bruno","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072883486","display_name":"Loretta Gammaitoni","orcid":"https://orcid.org/0000-0003-2251-9578","observed_orcids":["https://orcid.org/0000-0003-2251-9578"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Loretta Gammaitoni","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041240875","display_name":"Dario Sangiolo","orcid":"https://orcid.org/0000-0002-7163-7071","observed_orcids":["https://orcid.org/0000-0002-7163-7071"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario Sangiolo","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054601656","display_name":"Erica Torchiaro","orcid":"https://orcid.org/0000-0002-8984-882X","observed_orcids":["https://orcid.org/0000-0002-8984-882X"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erica Torchiaro","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052085580","display_name":"Lorenzo D\u2019Ambrosio","orcid":"https://orcid.org/0000-0003-3294-8819","observed_orcids":["https://orcid.org/0000-0003-3294-8819"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo D'Ambrosio","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073707704","display_name":"Franca Fagioli","orcid":"https://orcid.org/0000-0002-9257-900X","observed_orcids":["https://orcid.org/0000-0002-9257-900X"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franca Fagioli","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051031495","display_name":"Stefano Maria Ferrari","orcid":"https://orcid.org/0000-0002-6607-215X","observed_orcids":["https://orcid.org/0000-0002-6607-215X"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Ferrari","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068651198","display_name":"Marco Alberghini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Alberghini","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083948167","display_name":"Piero Picci","orcid":"https://orcid.org/0000-0002-8519-4101","observed_orcids":["https://orcid.org/0000-0002-8519-4101"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Picci","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056702454","display_name":"Massimo Aglietta","orcid":"https://orcid.org/0000-0002-2255-7972","observed_orcids":["https://orcid.org/0000-0002-2255-7972"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Aglietta","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050031420","display_name":"Giovanni Grignani","orcid":"https://orcid.org/0000-0001-5515-569X","observed_orcids":["https://orcid.org/0000-0001-5515-569X"]},"institutions":[{"id":"https://openalex.org/I4210106593","display_name":"Ospedale Sant'Anna","ror":"https://ror.org/010d4kb47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903","https://openalex.org/I4210106593"]},{"id":"https://openalex.org/I4210121742","display_name":"Istituto Ortopedico Rizzoli","ror":"https://ror.org/02ycyys66","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210121742","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I4210167100","display_name":"Fondazione Piemontese per la Ricerca sul Cancro Onlus","ror":"https://ror.org/05mg74j30","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Grignani","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdO","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Group, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 2Department of Oncology, University of Torino Medical School, 3Tumor Microenvironment, Fondazione Piemontese per la Ricerca sul Cancro-ONLUS, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 4Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy; 5Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 6Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy; 7Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy; 8Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy; 9Medical Oncology, Fondazione del Piemonte per \u00cdOncologia, Institute for","institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"]},{"raw_affiliation_string":"Cancer Genetics, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cell Therapy, Fondazione del Piemonte per l'Oncologia, Institute for Cancer Research and Treatment at Candiolo, Torino, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Molecular Biotechnology Center and Center of Experimental Research and Medical Sciences, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy","institution_ids":["https://openalex.org/I4210121742"]},{"raw_affiliation_string":"Division of Pediatric Onco-Hematology, Sant'Anna OIRM Hospital, Torino, Italy","institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210136185"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5052120219"],"corresponding_institution_ids":["https://openalex.org/I4210106593","https://openalex.org/I4210121742","https://openalex.org/I4210136185","https://openalex.org/I4210151091","https://openalex.org/I4210167100","https://openalex.org/I55143463"],"apc_list":null,"apc_paid":null,"fwci":4.1336,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.959119,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"19","issue":"8","first_page":"2117","last_page":"2131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.14059999585151672,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":1.0},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mtorc2","display_name":"mTORC2","score":1.0},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7369999885559082},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.4790000021457672},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5559999942779541},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.47600001096725464},{"id":"https://openalex.org/keywords/nod-scid-xenograft","display_name":"NOD/SCID xenograft","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chorioallantoic-membrane-angiogenesis","display_name":"chorioallantoic membrane angiogenesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/ribosomal-protein-s6","display_name":"ribosomal protein S6","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.8438481092453003},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.808627724647522},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.789129912853241},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6982614994049072},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6824924945831299},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.6357603073120117},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.47014525532722473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3477799892425537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3418528437614441},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3123876452445984},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2561798095703125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19710224866867065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06155800819396973},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076225","descriptor_name":"Mechanistic Target of Rapamycin Complex 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-12-2293","doi":"https://doi.org/10.1158/1078-0432.ccr-12-2293","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-2293","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:23434734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23434734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1489395","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1489395/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Cancer Res , 19 (8) pp. 2117-2131. (2013)","raw_type":"Article"},{"id":"pmh:oai:iris.unito.it:2318/132449","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2318/132449","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1573363574","https://openalex.org/W1970550717","https://openalex.org/W1983698019","https://openalex.org/W1998461609","https://openalex.org/W2024831747","https://openalex.org/W2025724790","https://openalex.org/W2051360623","https://openalex.org/W2056445663","https://openalex.org/W2061278804","https://openalex.org/W2062289724","https://openalex.org/W2065034430","https://openalex.org/W2065887259","https://openalex.org/W2068048197","https://openalex.org/W2077014658","https://openalex.org/W2077546229","https://openalex.org/W2088749541","https://openalex.org/W2093216555","https://openalex.org/W2098279865","https://openalex.org/W2102056525","https://openalex.org/W2103405666","https://openalex.org/W2103628478","https://openalex.org/W2125608170","https://openalex.org/W2127748864","https://openalex.org/W2127931911","https://openalex.org/W2128188903","https://openalex.org/W2134138119","https://openalex.org/W2140765540","https://openalex.org/W2146798222","https://openalex.org/W2150595264","https://openalex.org/W2152274262","https://openalex.org/W2152289580","https://openalex.org/W2154500154","https://openalex.org/W2157603347","https://openalex.org/W2161377790","https://openalex.org/W2165002727","https://openalex.org/W2167348613","https://openalex.org/W2399808830"],"related_works":["https://openalex.org/W2185275866","https://openalex.org/W2244670527","https://openalex.org/W2068242641","https://openalex.org/W1999127018","https://openalex.org/W1590907824","https://openalex.org/W2128486176","https://openalex.org/W2907339157","https://openalex.org/W2041527090","https://openalex.org/W3082294268","https://openalex.org/W2161377790"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,204],"multikinase":[2],"inhibitor":[3],"sorafenib":[4,34,92,160,183,236,239],"displays":[5],"antitumor":[6,132,245],"activity":[7,246],"in":[8,14,74,141,150,152,175,187,256],"preclinical":[9,258],"models":[10],"of":[11,101,190,252],"osteosarcoma.":[12],"However,":[13],"sorafenib-treated":[15],"patients":[16],"with":[17,91,125,179,184,242],"metastatic-relapsed":[18],"osteosarcoma,":[19],"disease":[20],"stabilization":[21],"and":[22,27,47,60,69,85,99,111,133,137,149,155,199,211,221,225],"tumor":[23,216],"shrinkage":[24],"were":[25,49,72,113,128,139],"short-lived":[26],"drug":[28],"resistance":[29],"occurred.":[30],"We":[31],"explored":[32],"the":[33,53,102,253,257],"treatment":[35,90],"escape":[36,233],"mechanisms":[37],"to":[38,51,130],"overcome":[39],"their":[40],"drawbacks.":[41],"EXPERIMENTAL":[42],"DESIGN:":[43],"Immunoprecipitation,":[44],"Western":[45],"blotting,":[46],"immunohistochemistry":[48],"used":[50,129],"analyze":[52],"mTOR":[54,61,254],"pathway":[55,255],"[mTOR":[56],"complex":[57,62,202],"1":[58],"(mTORC1)":[59],"2":[63],"(mTORC2)].":[64],"Cell":[65,104],"viability,":[66],"colony":[67],"growth,":[68,217],"cell":[70,77],"migration":[71],"evaluated":[73,140],"different":[75],"osteosarcoma":[76],"lines":[78],"(MNNG-HOS,":[79],"HOS,":[80],"KHOS/NP,":[81],"MG63,":[82],"U-2OS,":[83],"SJSA-1,":[84],"SAOS-2)":[86],"after":[87],"scalar":[88],"dose":[89],"(10-0.625":[93],"\u03bcmol/L),":[94],"rapamycin-analog":[95],"everolimus":[96,185],"(100-6.25":[97],"nmol/L),":[98],"combinations":[100],"two.":[103],"cycle,":[105],"reactive":[106],"oxygen":[107],"species":[108],"(ROS)":[109],"production,":[110],"apoptosis":[112],"assessed":[114],"by":[115,143,249],"flow":[116],"cytometry.":[117],"Nonobese":[118],"diabetic/severe":[119],"combined":[120,241],"immunodeficient":[121],"(NOD/SCID)":[122],"mice":[123,154],"injected":[124],"MNNG-HOS":[126,176],"cells":[127],"determine":[131],"antimetastatic":[134],"effects.":[135],"Angiogenesis":[136],"vascularization":[138],"vitro":[142],"exploiting":[144],"endothelial":[145],"branching":[146],"morphogenesis":[147],"assays":[148],"vivo":[151],"xenografted":[153],"chorioallantoic":[156],"membranes.":[157],"RESULTS:":[158],"After":[159],"treatment,":[161],"mTORC1":[162,192],"signaling":[163],"was":[164,171],"reduced":[165,223],"(downstream":[166],"target":[167],"P-S6),":[168],"whereas":[169],"mTORC2":[170,200,229],"increased":[172,248],"(phospho-mTOR":[173],"Ser2481)":[174],"xenografts":[177],"compared":[178],"vehicle-treated":[180],"mice.":[181],"Combining":[182],"resulted":[186],"complete":[188,250],"abrogation":[189],"both":[191],"[through":[193],"ROS-mediated":[194],"AMP-activated":[195],"kinase":[196],"(AMPK)":[197],"activation]":[198],"(through":[201],"disassembly).":[203],"sorafenib/everolimus":[205],"combination":[206],"yielded:":[207],"(i)":[208],"enhanced":[209],"antiproliferative":[210],"proapoptotic":[212],"effects,":[213],"(ii)":[214],"impaired":[215],"(iii)":[218],"potentiated":[219],"antiangiogenesis,":[220],"(iv)":[222],"migratory":[224],"metastatic":[226],"potential.":[227],"CONCLUSION:":[228],"activation":[230],"is":[231,240,247],"an":[232],"mechanism":[234],"from":[235],"treatment.":[237],"When":[238],"everolimus,":[243],"its":[244],"inhibition":[251],"setting.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
