{"id":"https://openalex.org/W2002115013","doi":"https://doi.org/10.1164/ajrccm.159.1.9709109","title":"Airway and Lung Tissue Mechanics in Asthma: Effects of Albuterol","display_name":"Airway and Lung Tissue Mechanics in Asthma: Effects of Albuterol","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2002115013","doi":"https://doi.org/10.1164/ajrccm.159.1.9709109","mag":"2002115013","pmid":"https://pubmed.ncbi.nlm.nih.gov/9872836"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.159.1.9709109","doi":"https://doi.org/10.1164/ajrccm.159.1.9709109","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.159.1.9709109","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016079340","display_name":"David W. Kaczka","orcid":"https://orcid.org/0000-0003-4378-5242","observed_orcids":["https://orcid.org/0000-0003-4378-5242"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID W. KACZKA","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts","Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109808270","display_name":"Edward P. Ingenito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EDWARD P. INGENITO","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046059982","display_name":"Elliot Israel","orcid":"https://orcid.org/0000-0002-2470-856X","observed_orcids":["https://orcid.org/0000-0002-2470-856X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ELLIOT ISRAEL","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058910452","display_name":"Kenneth R. Lutchen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KENNETH R. LUTCHEN","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University; and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3982,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.92390945,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"159","issue":"1","first_page":"169","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/airway-resistance","display_name":"airway resistance","score":0.8849999904632568},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lung-elastance","display_name":"lung elastance","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tissue-damping","display_name":"tissue damping","score":0.7179999947547913},{"id":"https://openalex.org/keywords/viscoelastic-tissue","display_name":"viscoelastic tissue","score":0.6110000014305115},{"id":"https://openalex.org/keywords/pulmonary-mechanics","display_name":"lung mechanics","score":0.5019999742507935},{"id":"https://openalex.org/keywords/asthma-phenotypes","display_name":"asthma phenotypes","score":0.41100001335144043},{"id":"https://openalex.org/keywords/bronchodilator-response","display_name":"bronchodilator response","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7841042280197144},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.7409519553184509},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.6219349503517151},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6107221841812134},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5465970635414124},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5403568744659424},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.4895261228084564},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47661224007606506},{"id":"https://openalex.org/C136936797","wikidata":"https://www.wikidata.org/wiki/Q2990558","display_name":"Pulmonary compliance","level":3,"score":0.4532204866409302},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.41026079654693604},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34227004647254944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3200736939907074}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008170","descriptor_name":"Lung Compliance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008170","descriptor_name":"Lung Compliance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013147","descriptor_name":"Spirometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015656","descriptor_name":"Respiratory Mechanics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm.159.1.9709109","doi":"https://doi.org/10.1164/ajrccm.159.1.9709109","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.159.1.9709109","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:9872836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9872836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.4399999976158142}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W6875111","https://openalex.org/W47757837","https://openalex.org/W1774162171","https://openalex.org/W1860094758","https://openalex.org/W1915943632","https://openalex.org/W1953370205","https://openalex.org/W1968559856","https://openalex.org/W1978177900","https://openalex.org/W1994157034","https://openalex.org/W2005507401","https://openalex.org/W2006171352","https://openalex.org/W2009263098","https://openalex.org/W2020752525","https://openalex.org/W2046915036","https://openalex.org/W2048073033","https://openalex.org/W2094216179","https://openalex.org/W2099090035","https://openalex.org/W2121199401","https://openalex.org/W2130404240","https://openalex.org/W2132011458","https://openalex.org/W2143645698","https://openalex.org/W2156828502","https://openalex.org/W2179076074","https://openalex.org/W2185948560","https://openalex.org/W2252935822","https://openalex.org/W2255920711","https://openalex.org/W2259147694","https://openalex.org/W2269644498","https://openalex.org/W2274798774","https://openalex.org/W2280341419","https://openalex.org/W2285917071","https://openalex.org/W2339255964","https://openalex.org/W2409483018","https://openalex.org/W2409814371","https://openalex.org/W2414708874","https://openalex.org/W2414929291","https://openalex.org/W2415284632","https://openalex.org/W2436069018"],"related_works":["https://openalex.org/W2409483018","https://openalex.org/W2417796286","https://openalex.org/W2058345956","https://openalex.org/W2130404240","https://openalex.org/W1960703293","https://openalex.org/W4229457697","https://openalex.org/W2122586462","https://openalex.org/W2174182048","https://openalex.org/W2171181155","https://openalex.org/W1915107197"],"abstract_inverted_index":{"We":[0,234],"examined":[1],"the":[2,63,138,146,155,164,167,175,210,241,264],"partitioning":[3],"of":[4,29,62,70,99,140,166,172,217,245,253,263,266],"total":[5],"lung":[6,46,73],"resistance":[7,11,15],"(RL)":[8],"into":[9,174],"airway":[10,71,142,176],"(Raw)":[12],"and":[13,32,45,65,72,107,123,199,219,228,255],"tissue":[14,74,200,205],"(Rti)":[16],"in":[17,49,145,163,170,185,197,209,225,237],"patients":[18],"with":[19,95,182],"mild":[20],"to":[21,27,42,55,103,221,257,260],"moderate":[22],"asthma":[23],"(baseline":[24],"FEV1,":[25],"54":[26],"91%":[28],"predicted)":[30],"before":[31,106],"after":[33,108,202,232],"albuterol":[34],"inhalation.":[35],"An":[36],"optimal":[37],"ventilator":[38],"waveform":[39],"was":[40],"used":[41],"measure":[43],"RL":[44,64,86,122,222,246,258],"elastance":[47,206],"(EL)":[48],"21":[50],"asthmatics":[51],"from":[52],"approximately":[53],"0.1":[54],"8":[56],"Hz":[57],"during":[58],"tidal":[59],"excursions.":[60],"Analysis":[61],"EL":[66,125],"provided":[67],"separate":[68],"estimates":[69],"properties.":[75],"Eleven":[76],"subjects,":[77,113],"classified":[78,114],"as":[79,115],"Type":[80,116,156,186,211],"A":[81],"asthmatics,":[82,118],"displayed":[83],"slightly":[84],"elevated":[85,121,129],"but":[87,149,204],"normal":[88],"EL.":[89],"Their":[90],"data":[91,179],"were":[92,159,180,223],"well":[93],"described":[94],"a":[96],"model":[97,147],"consisting":[98],"homogeneous":[100],"airways":[101],"leading":[102],"viscoelastic":[104],"tissues":[105],"albuterol.":[109,233],"The":[110,214,250],"other":[111],"10":[112],"B":[117,157,187,212],"demonstrated":[119,191],"highly":[120,128],"an":[124,141],"that":[126,154,236],"became":[127],"at":[130,247],"frequencies":[131],"above":[132],"2":[133],"Hz.":[134],"These":[135],"subjects":[136,158],"required":[137],"inclusion":[139],"wall":[143],"compliance":[144],"prealbuterol":[148],"not":[150,230],"postalbuterol.":[151],"This":[152],"suggests":[153],"experiencing":[160],"pronounced":[161],"constriction":[162,184],"periphery":[165],"lung,":[168],"resulting":[169],"shunting":[171],"flow":[173],"walls.":[177],"Spirometric":[178],"consistent":[181],"higher":[183],"subjects.":[188],"Both":[189],"groups":[190,227],"significant":[192],"(p":[193],"<":[194],"0.05)":[195],"decreases":[196],"Raw":[198,218,239,254],"damping":[201],"albuterol,":[203],"decreased":[207],"only":[208],"group.":[213],"percent":[215],"contributions":[216,252],"Rti":[220,256],"similar":[224],"both":[226],"did":[229],"change":[231],"conclude":[235],"asthma,":[238],"comprises":[240],"majority":[242],"(>":[243],"70%)":[244],"breathing":[248],"frequencies.":[249],"relative":[251],"appear":[259],"be":[261],"independent":[262],"degree":[265],"smooth":[267],"muscle":[268],"constriction.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}