{"id":"https://openalex.org/W2002107594","doi":"https://doi.org/10.1016/s0953-6205(01)00172-8","title":"Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C-reactive protein","display_name":"Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C-reactive protein","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2002107594","doi":"https://doi.org/10.1016/s0953-6205(01)00172-8","mag":"2002107594","pmid":"https://pubmed.ncbi.nlm.nih.gov/11711273"},"language":"en","primary_location":{"id":"doi:10.1016/s0953-6205(01)00172-8","doi":"https://doi.org/10.1016/s0953-6205(01)00172-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0953-6205(01)00172-8","pdf_url":null,"source":{"id":"https://openalex.org/S138083468","display_name":"European Journal of Internal Medicine","issn_l":"0953-6205","issn":["0953-6205","1879-0828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053405308","display_name":"Paul L. van Haelst","orcid":"https://orcid.org/0000-0002-6942-2602","observed_orcids":["https://orcid.org/0000-0002-6942-2602"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"P.L van Haelst","raw_affiliation_strings":["Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB, Groningen, The Netherlands. p.l.van.haelst@thorax.azg.nl","Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB, Groningen, The Netherlands. p.l.van.haelst@thorax.azg.nl","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110011696","display_name":"Jaap J. van Doormaal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.J van Doormaal","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109332033","display_name":"Johan F. May","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.F May","raw_affiliation_strings":["Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019315381","display_name":"Rijk O. B. Gans","orcid":"https://orcid.org/0000-0001-5481-2387","observed_orcids":["https://orcid.org/0000-0001-5481-2387"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R.O.B Gans","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090763481","display_name":"Harry J.G.M. Crijns","orcid":"https://orcid.org/0000-0003-1073-5337","observed_orcids":["https://orcid.org/0000-0003-1073-5337"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H.J.G.M Crijns","raw_affiliation_strings":["Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thorax Centre, Department of Cardiology, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001643187","display_name":"Jan Willem Cohen Tervaert","orcid":"https://orcid.org/0000-0001-7407-6364","observed_orcids":["https://orcid.org/0000-0001-7407-6364"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.W Cohen Tervaert","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Groningen, P.O. Box 30001, NL-9700 RB Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053405308"],"corresponding_institution_ids":["https://openalex.org/I1334415907"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":3.4159,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.92720123,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"12","issue":"6","first_page":"503","last_page":"509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluvastatin","display_name":"fluvastatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9330000281333923},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neopterin","display_name":"neopterin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/monocyte-macrophage-activation","display_name":"monocyte/macrophage activation","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C2776603314","wikidata":"https://www.wikidata.org/wiki/Q908292","display_name":"Neopterin","level":2,"score":0.896153450012207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8318628072738647},{"id":"https://openalex.org/C2778417548","wikidata":"https://www.wikidata.org/wiki/Q417942","display_name":"Fluvastatin","level":3,"score":0.8255555033683777},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6291166543960571},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5888258814811707},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.585904061794281},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5231531858444214},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.5001778602600098},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49116823077201843},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4654214084148407},{"id":"https://openalex.org/C2779519902","wikidata":"https://www.wikidata.org/wiki/Q1240093","display_name":"Pravastatin","level":3,"score":0.4266546964645386},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.41990673542022705},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3704015016555786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33406946063041687},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/s0953-6205(01)00172-8","doi":"https://doi.org/10.1016/s0953-6205(01)00172-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0953-6205(01)00172-8","pdf_url":null,"source":{"id":"https://openalex.org/S138083468","display_name":"European Journal of Internal Medicine","issn_l":"0953-6205","issn":["0953-6205","1879-0828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:11711273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11711273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/6f70184e-90f0-4631-96a0-c6fda7768852","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/6f70184e-90f0-4631-96a0-c6fda7768852","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"van Haelst, P L, van Doormaal, J J, May, J F, Gans, R O, Crijns, H J & Tervaert, J W 2001, 'Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C-reactive protein', European Journal of Internal Medicine, vol. 12, no. 6, pp. 503-509. https://doi.org/10.1016/s0953-6205(01)00172-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/6f70184e-90f0-4631-96a0-c6fda7768852","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/6f70184e-90f0-4631-96a0-c6fda7768852","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Internal Medicine, 12(6), 503 - 509. ELSEVIER SCIENCE BV","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1493971026","https://openalex.org/W1537398036","https://openalex.org/W1557998083","https://openalex.org/W1969214107","https://openalex.org/W1984829261","https://openalex.org/W2026759435","https://openalex.org/W2046750893","https://openalex.org/W2049836623","https://openalex.org/W2054096510","https://openalex.org/W2060351304","https://openalex.org/W2061904816","https://openalex.org/W2072308694","https://openalex.org/W2072532276","https://openalex.org/W2072883380","https://openalex.org/W2079188293","https://openalex.org/W2108203235","https://openalex.org/W2138809584","https://openalex.org/W2145053304","https://openalex.org/W2159633079","https://openalex.org/W2161780828","https://openalex.org/W2239990264","https://openalex.org/W2322095705","https://openalex.org/W2324841714","https://openalex.org/W2331959986","https://openalex.org/W2396356772","https://openalex.org/W2466932343","https://openalex.org/W2608539973","https://openalex.org/W4213225455","https://openalex.org/W4238678736","https://openalex.org/W4246764494"],"related_works":["https://openalex.org/W7097846700","https://openalex.org/W2401152173","https://openalex.org/W1989698636","https://openalex.org/W1976989874","https://openalex.org/W2099284947","https://openalex.org/W2066994466","https://openalex.org/W2039643538","https://openalex.org/W2051252262","https://openalex.org/W7099149397","https://openalex.org/W1981725015"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
