{"id":"https://openalex.org/W2002091685","doi":"https://doi.org/10.1016/j.pbb.2011.06.026","title":"Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease","display_name":"Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease","publication_year":2011,"publication_date":"2011-07-09","ids":{"openalex":"https://openalex.org/W2002091685","doi":"https://doi.org/10.1016/j.pbb.2011.06.026","mag":"2002091685","pmid":"https://pubmed.ncbi.nlm.nih.gov/21741988","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3156390"},"language":"en","primary_location":{"id":"doi:10.1016/j.pbb.2011.06.026","doi":"https://doi.org/10.1016/j.pbb.2011.06.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pbb.2011.06.026","pdf_url":null,"source":{"id":"https://openalex.org/S59685179","display_name":"Pharmacology Biochemistry and Behavior","issn_l":"0091-3057","issn":["0091-3057","1873-5177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Biochemistry and Behavior","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3156390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047258794","display_name":"Gaurav Patki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaurav Patki","raw_affiliation_strings":["Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA","Department of Pharmacological & Pharmaceutical Sciences College of Pharmacy University of Houston Houston TX 77204 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"Department of Pharmacological & Pharmaceutical Sciences College of Pharmacy University of Houston Houston TX 77204 USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113656593","display_name":"Yuen\u2010Sum Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuen-Sum Lau","raw_affiliation_strings":["Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, United States","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113656593"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":3.4933,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.92339617,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"99","issue":"4","first_page":"704","last_page":"711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.9599999785423279},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.625},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9330000281333923},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8450000286102295},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9769999980926514},{"id":"https://openalex.org/keywords/locomotor-deficits","display_name":"locomotor deficits","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.9129999876022339},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.5270000100135803},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neurobehavioral-deficits","display_name":"neurobehavioral deficits","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9238632321357727},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7271941900253296},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6188211441040039},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5931798815727234},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.5448787212371826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5089607238769531},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5015304088592529},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4698167145252228},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.4511224627494812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4411665201187134},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4053940176963806},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.38794347643852234},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31178200244903564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29336434602737427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10977098345756531}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011339","descriptor_name":"Probenecid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020267","descriptor_name":"MPTP Poisoning","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020267","descriptor_name":"MPTP Poisoning","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.pbb.2011.06.026","doi":"https://doi.org/10.1016/j.pbb.2011.06.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pbb.2011.06.026","pdf_url":null,"source":{"id":"https://openalex.org/S59685179","display_name":"Pharmacology Biochemistry and Behavior","issn_l":"0091-3057","issn":["0091-3057","1873-5177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology Biochemistry and Behavior","raw_type":"journal-article"},{"id":"pmid:21741988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21741988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology, biochemistry, and behavior","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3156390","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3156390","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacol Biochem Behav","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3156390","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3156390","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacol Biochem Behav","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7192186952","display_name":"Impact of Exercise on Parkinson's Disease Therapy","funder_award_id":"R01NS047920","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W204047393","https://openalex.org/W388660883","https://openalex.org/W1485468448","https://openalex.org/W1504584187","https://openalex.org/W1574231266","https://openalex.org/W1800951710","https://openalex.org/W1821300643","https://openalex.org/W1966016390","https://openalex.org/W1966148111","https://openalex.org/W1966697917","https://openalex.org/W1968954752","https://openalex.org/W1970310765","https://openalex.org/W1976345822","https://openalex.org/W1979686914","https://openalex.org/W1998994558","https://openalex.org/W1999497665","https://openalex.org/W1999970873","https://openalex.org/W2004877758","https://openalex.org/W2005182361","https://openalex.org/W2005779608","https://openalex.org/W2022834361","https://openalex.org/W2024022041","https://openalex.org/W2024506496","https://openalex.org/W2032140182","https://openalex.org/W2033832481","https://openalex.org/W2042630261","https://openalex.org/W2042663107","https://openalex.org/W2046759540","https://openalex.org/W2052421237","https://openalex.org/W2055308573","https://openalex.org/W2055557007","https://openalex.org/W2056122458","https://openalex.org/W2058240863","https://openalex.org/W2059718548","https://openalex.org/W2068958995","https://openalex.org/W2069433213","https://openalex.org/W2079231229","https://openalex.org/W2080945452","https://openalex.org/W2090435205","https://openalex.org/W2095125882","https://openalex.org/W2112777355","https://openalex.org/W2128672762","https://openalex.org/W2129375925","https://openalex.org/W2134593233","https://openalex.org/W2140647923","https://openalex.org/W2157205154","https://openalex.org/W2158817614","https://openalex.org/W2167417799","https://openalex.org/W2494136635"],"related_works":["https://openalex.org/W82380603","https://openalex.org/W2160666444","https://openalex.org/W3206603152","https://openalex.org/W2002508244","https://openalex.org/W2290418577","https://openalex.org/W4309476570","https://openalex.org/W2536062187","https://openalex.org/W1981776904","https://openalex.org/W2130281784","https://openalex.org/W2203137514"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}