{"id":"https://openalex.org/W2002040808","doi":"https://doi.org/10.1046/j.1525-1411.1999.14010.x","title":"A Phase II Trial of Oral Trimethylcolchicinic Acid in Patients with Hormone Refractory Prostate Cancer","display_name":"A Phase II Trial of Oral Trimethylcolchicinic Acid in Patients with Hormone Refractory Prostate Cancer","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2002040808","doi":"https://doi.org/10.1046/j.1525-1411.1999.14010.x","mag":"2002040808"},"language":"en","primary_location":{"id":"doi:10.1046/j.1525-1411.1999.14010.x","doi":"https://doi.org/10.1046/j.1525-1411.1999.14010.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1525-1411.1999.14010.x","pdf_url":null,"source":{"id":"https://openalex.org/S119077848","display_name":"The Prostate Journal","issn_l":"1095-5100","issn":["1095-5100","1525-1411"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051856622","display_name":"Bruce Brockstein","orcid":"https://orcid.org/0000-0002-8854-0372","observed_orcids":["https://orcid.org/0000-0002-8854-0372"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce E. Brockstein","raw_affiliation_strings":["Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003728236","display_name":"Dale Randall Shepard","orcid":"https://orcid.org/0000-0003-4310-6019","observed_orcids":["https://orcid.org/0000-0003-4310-6019"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale R. Shepard","raw_affiliation_strings":["Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112218423","display_name":"John W. Kugler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136917","display_name":"Illinois CancerCare","ror":"https://ror.org/03vfgta75","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136917"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Kugler","raw_affiliation_strings":["Oncology/Hematology Associates of Central Illinois, Peoria, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology/Hematology Associates of Central Illinois, Peoria, Illinois, U.S.A","institution_ids":["https://openalex.org/I4210136917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037740674","display_name":"Paul A. S. Fishkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136917","display_name":"Illinois CancerCare","ror":"https://ror.org/03vfgta75","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136917"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Fishkin","raw_affiliation_strings":["Oncology/Hematology Associates of Central Illinois, Peoria, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology/Hematology Associates of Central Illinois, Peoria, Illinois, U.S.A","institution_ids":["https://openalex.org/I4210136917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090087470","display_name":"Rose L Arrieta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rose Arrieta","raw_affiliation_strings":["Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068268371","display_name":"Mark J. Ratain","orcid":"https://orcid.org/0000-0002-0938-4392","observed_orcids":["https://orcid.org/0000-0002-0938-4392"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Ratain","raw_affiliation_strings":["Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Everett E. Vokes","raw_affiliation_strings":["Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059219836","display_name":"Nicholas J. Vogelzang","orcid":"https://orcid.org/0000-0002-7665-6079","observed_orcids":["https://orcid.org/0000-0002-7665-6079"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Vogelzang","raw_affiliation_strings":["Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051856622"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.09694989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"4","first_page":"195","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/colchicine-derivatives","display_name":"colchicine derivatives","score":0.8550000190734863},{"id":"https://openalex.org/keywords/oral-chemotherapy","display_name":"oral chemotherapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.875},{"id":"https://openalex.org/keywords/chemotherapy-naive-patients","display_name":"chemotherapy-naive patients","score":0.7089999914169312},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6197859644889832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5954596996307373},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5864666104316711},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5334432721138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.502680778503418},{"id":"https://openalex.org/C2779051857","wikidata":"https://www.wikidata.org/wiki/Q911386","display_name":"Stomatitis","level":2,"score":0.49261385202407837},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4898175895214081},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4748433232307434},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4636225998401642},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43839892745018005},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.42026960849761963},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36077427864074707},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3253045082092285}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1046/j.1525-1411.1999.14010.x","doi":"https://doi.org/10.1046/j.1525-1411.1999.14010.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1525-1411.1999.14010.x","pdf_url":null,"source":{"id":"https://openalex.org/S119077848","display_name":"The Prostate Journal","issn_l":"1095-5100","issn":["1095-5100","1525-1411"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1565731923","https://openalex.org/W1970014957","https://openalex.org/W2002163830","https://openalex.org/W2019340569","https://openalex.org/W2413829798","https://openalex.org/W2419233578"],"related_works":["https://openalex.org/W1985022423","https://openalex.org/W2941558627","https://openalex.org/W2416745033","https://openalex.org/W1970014957","https://openalex.org/W2069549911","https://openalex.org/W1991753768","https://openalex.org/W1816774827","https://openalex.org/W1994049816","https://openalex.org/W2074590437","https://openalex.org/W1971032648"],"abstract_inverted_index":{"Abstract":[0],"Hormone":[1],"refractory":[2],"prostate":[3,74],"cancer":[4],"(HRPC)":[5],"will":[6],"affect":[7],"more":[8],"than":[9],"40,000":[10],"men":[11,45],"in":[12,16,25,37],"the":[13,106,115,119,124,152],"United":[14],"States":[15],"1999,":[17],"and":[18,79,100,123,142,144],"only":[19],"a":[20,38],"few":[21],"drugs":[22],"have":[23],"activity":[24],"this":[26,84],"disease.":[27],"We":[28,128],"studied":[29],"trimethylcolchicinic":[30],"acid":[31],"(TMCA),":[32],"an":[33,68],"oral":[34],"colchicine":[35],"derivative,":[36],"Phase":[39],"II":[40],"trial":[41],"involving":[42],"18":[43],"chemotherapy\u2010naive":[44],"with":[46,59,114],"HRPC.":[47],"TMCA,":[48],"5":[49,57],"mg/m2/day,":[50],"was":[51],"given":[52],"orally":[53],"for":[54],"4":[55,99],"or":[56,73],"days":[58],"cycles":[60],"repeated":[61],"every":[62],"3":[63],"weeks.":[64],"No":[65],"patients":[66],"showed":[67],"objective":[69],"response":[70],"by":[71],"clinical":[72,134],"specific":[75],"antigen":[76],"criteria.":[77],"Neutropenia":[78],"stomatitis":[80],"were":[81],"common":[82],"on":[83,97,136],"schedule.":[85],"One":[86],"fatal":[87],"episode":[88],"of":[89,109,126],"neutropenic":[90],"fever":[91],"occurred.":[92],"Pharmacokinetics":[93],"suggested":[94],"drug":[95],"accumulation":[96],"Days":[98],"5.":[101],"The":[102],"cumulative":[103],"area":[104],"under":[105],"curve":[107],"(AUC)":[108],"concentration":[110],"\u00d7":[111],"time":[112],"correlated":[113],"log":[116,120],"neutrophil":[117],"nadir,":[118,122],"platelet":[121],"severity":[125],"stomatitis.":[127],"conclude":[129],"that":[130,145],"TMCA":[131],"has":[132],"no":[133],"effect":[135],"HRPC":[137],"despite":[138],"severe":[139],"hematologic":[140,147],"toxicity":[141,148],"stomatitis,":[143],"its":[146],"is":[149],"related":[150],"to":[151],"AUC.":[153]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
