{"id":"https://openalex.org/W2002014356","doi":"https://doi.org/10.1111/j.1469-7793.1999.177af.x","title":"Tyrosine kinase involvement in apamin\u2010sensitive inhibitory responses of rat distal colon","display_name":"Tyrosine kinase involvement in apamin\u2010sensitive inhibitory responses of rat distal colon","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2002014356","doi":"https://doi.org/10.1111/j.1469-7793.1999.177af.x","mag":"2002014356","pmid":"https://pubmed.ncbi.nlm.nih.gov/9831725","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2269060"},"language":"en","primary_location":{"id":"doi:10.1111/j.1469-7793.1999.177af.x","doi":"https://doi.org/10.1111/j.1469-7793.1999.177af.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1469-7793.1999.177af.x","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2269060/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010040847","display_name":"Tadayoshi Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadayoshi Takeuchi","raw_affiliation_strings":["Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531,, Japan. takeuchi@jyui.vet.osakafu-u.ac.jp","Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai 599-8531, Japan","Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531,, Japan. takeuchi@jyui.vet.osakafu-u.ac.jp","institution_ids":["https://openalex.org/I15807432"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]},{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111776419","display_name":"Masami Kishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Kishi","raw_affiliation_strings":["Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085929178","display_name":"Nobue Hirayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobue Hirayama","raw_affiliation_strings":["Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113525171","display_name":"Michiru Yamaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiru Yamaji","raw_affiliation_strings":["Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083073388","display_name":"Toshiaki Ishii","orcid":"https://orcid.org/0000-0002-6431-3263","observed_orcids":["https://orcid.org/0000-0002-6431-3263"]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Ishii","raw_affiliation_strings":["Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai 599-8531, Japan","Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]},{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110164333","display_name":"Hideaki Nishio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Nishio","raw_affiliation_strings":["Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048362422","display_name":"Fumiaki Hata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiaki Hata","raw_affiliation_strings":["Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai 599-8531, Japan","Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]},{"raw_affiliation_string":"Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Sakai 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077667212","display_name":"Tadashi Takewaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Takewaki","raw_affiliation_strings":["United Graduate School of Veterinary Science, Gifu University, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United Graduate School of Veterinary Science, Gifu University, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":1.156,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74634541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"514","issue":"1","first_page":"177","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-peptide","display_name":"pituitary adenylate cyclase-activating peptide","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/apamin-sensitive-potassium-channels","display_name":"apamin-sensitive potassium channels","score":0.8349999785423279},{"id":"https://openalex.org/keywords/small-conductance-calcium-activated-potassium-channels","display_name":"small conductance calcium-activated potassium channels","score":0.828000009059906},{"id":"https://openalex.org/keywords/non-adrenergic-non-cholinergic-inhibition","display_name":"non-adrenergic non-cholinergic inhibition","score":0.8849999904632568},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.7049999833106995},{"id":"https://openalex.org/keywords/membrane-hyperpolarization","display_name":"membrane hyperpolarization","score":0.8100000023841858},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9539999961853027},{"id":"https://openalex.org/keywords/smooth-muscle-relaxation","display_name":"smooth muscle relaxation","score":0.5389999747276306},{"id":"https://openalex.org/keywords/electrical-field-stimulation","display_name":"electrical field stimulation","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2776919887","wikidata":"https://www.wikidata.org/wiki/Q417260","display_name":"Apamin","level":3,"score":0.9773474931716919},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5752368569374084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.542772650718689},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.5291830897331238},{"id":"https://openalex.org/C149786707","wikidata":"https://www.wikidata.org/wiki/Q7390712","display_name":"SK channel","level":4,"score":0.46287113428115845},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4537241756916046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4502406418323517},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4330795407295227},{"id":"https://openalex.org/C2779496938","wikidata":"https://www.wikidata.org/wiki/Q14907479","display_name":"Pituitary adenylate cyclase-activating peptide","level":5,"score":0.430441677570343},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.41250425577163696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38088083267211914},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.3313536047935486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19716715812683105},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.18729665875434875},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.17790290713310242},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.15931165218353271},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12980926036834717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0966804027557373},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0677124559879303},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001030","descriptor_name":"Apamin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015124","descriptor_name":"8-Bromo Cyclic Adenosine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015124","descriptor_name":"8-Bromo Cyclic Adenosine Monophosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018999","descriptor_name":"Charybdotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1469-7793.1999.177af.x","doi":"https://doi.org/10.1111/j.1469-7793.1999.177af.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1469-7793.1999.177af.x","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:9831725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9831725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2269060","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2269060/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2269060","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2269060/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1596040936","https://openalex.org/W1656644300","https://openalex.org/W1820557413","https://openalex.org/W1964285407","https://openalex.org/W1965021019","https://openalex.org/W1966112698","https://openalex.org/W1974290405","https://openalex.org/W1979024318","https://openalex.org/W1981423842","https://openalex.org/W1984434545","https://openalex.org/W1999229966","https://openalex.org/W1999788892","https://openalex.org/W2000400143","https://openalex.org/W2002185725","https://openalex.org/W2009087599","https://openalex.org/W2013509592","https://openalex.org/W2018683381","https://openalex.org/W2029585845","https://openalex.org/W2035459073","https://openalex.org/W2039548501","https://openalex.org/W2050780404","https://openalex.org/W2054371611","https://openalex.org/W2054818418","https://openalex.org/W2058100090","https://openalex.org/W2058108253","https://openalex.org/W2058839845","https://openalex.org/W2065183122","https://openalex.org/W2073577985","https://openalex.org/W2079097756","https://openalex.org/W2080475705","https://openalex.org/W2085644581","https://openalex.org/W2102742081","https://openalex.org/W2117582045","https://openalex.org/W2168776095","https://openalex.org/W2171121921","https://openalex.org/W2222790656","https://openalex.org/W2247023146","https://openalex.org/W2255549157","https://openalex.org/W2284003820","https://openalex.org/W2400963480","https://openalex.org/W2412385351"],"related_works":["https://openalex.org/W3104555765","https://openalex.org/W2035459073","https://openalex.org/W3098559714","https://openalex.org/W3104310459","https://openalex.org/W3099823571","https://openalex.org/W1971169331","https://openalex.org/W1989173273","https://openalex.org/W2080475705","https://openalex.org/W2063963533","https://openalex.org/W1990988305"],"abstract_inverted_index":{"1.":[0],"It":[1],"has":[2],"been":[3],"suggested":[4,250],"that":[5,251],"pituitary":[6],"adenylate":[7],"cyclase":[8],"activating":[9],"peptide":[10],"(PACAP)":[11],"may":[12],"be":[13],"involved":[14,258],"in":[15,41,225,259],"the":[16,35,51,70,83,98,103,113,143,175,179,201,252,271],"non-adrenergic,":[17],"non-cholinergic":[18],"(NANC)":[19],"inhibitory":[20,152,203],"response":[21],"of":[22,25,38,50,90,102,115,126,135,148,154,164,174,178,211,217,254,262,273],"longitudinal":[23,52,116,218,263],"muscle":[24,117,219,264],"rat":[26,266],"distal":[27,267],"colon.":[28],"In":[29],"this":[30,42,187],"study,":[31],"we":[32],"have":[33],"investigated":[34],"intracellular":[36,226],"mechanism":[37],"PACAP-induced":[39,84,188,215,242,260],"relaxation":[40,49,85,114,216,261],"muscle.":[43,53,104,180],"2.":[44],"PACAP":[45,94,168],"induced":[46,118,169,206],"an":[47,133,170],"apamin-sensitive":[48,202,274],"The":[54,151,214],"tyrosine":[55,255],"kinase":[56,74,256],"inhibitors":[57],"genistein":[58,196],"at":[59,65,78,108,130,183,192,197,232,237],"10":[60,109,193,198,233],"microM":[61,80,110,185,194,199,234,239],"and":[62,88,157,195,235],"tyrphostin":[63,155],"25":[64,107,156,182,191,231],"30":[66,79],"microM,":[67,132],"but":[68],"not":[69,96,160],"cyclic":[71,99],"AMP-dependent":[72],"protein":[73],"inhibitor":[75],"Rp-8-bromoadenosine-3',5'-cyclic":[76],"monophosphorothioate":[77],"significantly":[81,111],"inhibited":[82,112,142,186,200],"to":[86,124,145],"60%":[87],"25%":[89],"control":[91,127,149,165],"values,":[92],"respectively.":[93],"did":[95],"increase":[97],"AMP":[100],"content":[101],"3.":[105],"Tyrphostin":[106,181,190,230],"by":[119,207],"electrical":[120],"field":[121],"stimulation":[122],"(EFS),":[123],"50%":[125],"values.":[128,150],"Apamin":[129],"1":[131,238],"antagonist":[134],"small":[136],"conductance":[137],"Ca2+-activated":[138],"K+":[139,275],"channels,":[140],"also":[141],"relaxation,":[144],"42":[146],"%":[147,163],"effects":[153],"apamin":[158,236],"were":[159],"additive":[161],"(44":[162],"values).":[166],"4.":[167],"apamin-sensitive,":[171],"slow":[172],"hyperpolarization":[173],"cell":[176],"membrane":[177],"3":[184],"hyperpolarization.":[189],"junction":[204],"potentials":[205],"a":[208,222],"single":[209],"pulse":[210],"EFS.":[212],"5.":[213],"occurred":[220],"with":[221],"concomitant":[223],"decrease":[224],"Ca2+":[227],"levels":[228],"([Ca2+]i).":[229],"abolished":[240],"these":[241,246],"responses.":[243],"6.":[244],"From":[245],"findings":[247],"it":[248],"is":[249,257],"activation":[253,272],"from":[265],"colon,":[268],"'upstream":[269],"of'":[270],"channels.":[276]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}