{"id":"https://openalex.org/W2002012958","doi":"https://doi.org/10.1074/jbc.m701396200","title":"Ceramide-1-phosphate Binds Group IVA Cytosolic Phospholipase a2 via a Novel Site in the C2 Domain","display_name":"Ceramide-1-phosphate Binds Group IVA Cytosolic Phospholipase a2 via a Novel Site in the C2 Domain","publication_year":2007,"publication_date":"2007-05-02","ids":{"openalex":"https://openalex.org/W2002012958","doi":"https://doi.org/10.1074/jbc.m701396200","mag":"2002012958","pmid":"https://pubmed.ncbi.nlm.nih.gov/17472963"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m701396200","doi":"https://doi.org/10.1074/jbc.m701396200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m701396200","pdf_url":"http://www.jbc.org/article/S0021925819780399/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819780399/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078195240","display_name":"Robert Virgil Stahelin","orcid":"https://orcid.org/0000-0001-5443-7863","observed_orcids":["https://orcid.org/0000-0001-5443-7863"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]},{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210134870","display_name":"Indiana University South Bend","ror":"https://ror.org/02s1hvj37","country_code":"US","type":"education","lineage":["https://openalex.org/I4210134870","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert V. Stahelin","raw_affiliation_strings":["Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298-0614, USA","Department of Biochemistry and Molecular Biology, Indiana University School of Medicine-South Bend, South Bend, Indiana 46617","Department of Chemistry and Biochemistry and The Walther Center for Cancer Research, University of Notre Dame, South Bend, Indiana 46617"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298-0614, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Indiana University School of Medicine-South Bend, South Bend, Indiana 46617","institution_ids":["https://openalex.org/I4210134870","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry and The Walther Center for Cancer Research, University of Notre Dame, South Bend, Indiana 46617","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020848095","display_name":"Preeti Subramanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Preeti Subramanian","raw_affiliation_strings":["Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018987978","display_name":"Mohsin Vora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohsin Vora","raw_affiliation_strings":["Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008657856","display_name":"Wonhwa Cho","orcid":"https://orcid.org/0000-0003-1410-2481","observed_orcids":["https://orcid.org/0000-0003-1410-2481"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wonhwa Cho","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607-7061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607-7061","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009408265","display_name":"Charles Edward Chalfant","orcid":"https://orcid.org/0000-0002-5844-5235","observed_orcids":["https://orcid.org/0000-0002-5844-5235"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles E. Chalfant","raw_affiliation_strings":["Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614","Research and Development, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"Research and Development, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249","institution_ids":["https://openalex.org/I2801770128"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009408265"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I72019824"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.3671,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.96119682,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"282","issue":"28","first_page":"20467","last_page":"20474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceramide-1-phosphate","display_name":"ceramide-1-phosphate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytosolic-phospholipase-a2-alpha","display_name":"cytosolic phospholipase A2 alpha","score":0.9449999928474426},{"id":"https://openalex.org/keywords/c2-domain","display_name":"C2 domain","score":0.9860000014305115},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.621999979019165},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5936532020568848},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.44752418994903564},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4204899072647095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4175184667110443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3970709443092346},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39143890142440796},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14647752046585083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054513","descriptor_name":"Group IV Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m701396200","doi":"https://doi.org/10.1074/jbc.m701396200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m701396200","pdf_url":"http://www.jbc.org/article/S0021925819780399/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17472963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17472963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1074/jbc.m701396200","doi":"https://doi.org/10.1074/jbc.m701396200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m701396200","pdf_url":"http://www.jbc.org/article/S0021925819780399/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2066916702","display_name":"The Role of Ceramide Kinase in Eicosanoid Synthesis","funder_award_id":"R01HL072925","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G232046512","display_name":null,"funder_award_id":"1CO6 RR 17393","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3405547518","display_name":"Membrane Targeting by Phosphoinositide Binding Proteins","funder_award_id":"R01GM068849","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5159579868","display_name":"Studies of Eicosanoid Biosynthetic Proteins","funder_award_id":"R01GM052598","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6256442718","display_name":"Structure Function Studies Of Membrane Binding Proteins","funder_award_id":"R01GM053987","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7275720460","display_name":"CONSTRUCTION OF SIGNALLING FACILITY","funder_award_id":"C06RR017393","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7483374307","display_name":null,"funder_award_id":"HL072925","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8752428544","display_name":"Sphingolipid Regulation of Caspase 9 Alternative Splicing","funder_award_id":"R01CA117950","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320311096","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002012958.pdf","grobid_xml":"https://content.openalex.org/works/W2002012958.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W88692221","https://openalex.org/W1483715738","https://openalex.org/W1484647033","https://openalex.org/W1486847030","https://openalex.org/W1509054438","https://openalex.org/W1512725913","https://openalex.org/W1544609822","https://openalex.org/W1552494303","https://openalex.org/W1563821664","https://openalex.org/W1587265394","https://openalex.org/W1971212998","https://openalex.org/W1974606305","https://openalex.org/W1981321625","https://openalex.org/W1993282564","https://openalex.org/W1994552081","https://openalex.org/W2007647806","https://openalex.org/W2011625746","https://openalex.org/W2012992067","https://openalex.org/W2031143643","https://openalex.org/W2037303082","https://openalex.org/W2041622964","https://openalex.org/W2042055643","https://openalex.org/W2043634254","https://openalex.org/W2051958752","https://openalex.org/W2052138090","https://openalex.org/W2052424724","https://openalex.org/W2057323682","https://openalex.org/W2059335098","https://openalex.org/W2062436492","https://openalex.org/W2076132445","https://openalex.org/W2077904086","https://openalex.org/W2081166773","https://openalex.org/W2084471484","https://openalex.org/W2084532148","https://openalex.org/W2086036400","https://openalex.org/W2088927230","https://openalex.org/W2090178694","https://openalex.org/W2110894800","https://openalex.org/W2122470288","https://openalex.org/W2125215711","https://openalex.org/W2129595885","https://openalex.org/W2144660603","https://openalex.org/W2154206349","https://openalex.org/W2156827480","https://openalex.org/W2169082359","https://openalex.org/W2169857435","https://openalex.org/W2949969992","https://openalex.org/W4233767967"],"related_works":["https://openalex.org/W2031143643","https://openalex.org/W4408261496","https://openalex.org/W2103305118","https://openalex.org/W800784263","https://openalex.org/W1972381160","https://openalex.org/W4396767763","https://openalex.org/W3177156880","https://openalex.org/W2155000549","https://openalex.org/W2043634254","https://openalex.org/W2584735078"],"abstract_inverted_index":{"Previously,":[0],"ceramide-1-phosphate":[1],"(C1P)":[2],"was":[3,37,160],"demonstrated":[4,96,114,172],"to":[5,39,203],"be":[6],"a":[7,123,197],"potent":[8],"and":[9,69,71,89,91,139,183],"specific":[10,32,161],"activator":[11],"of":[12,46,50,56,59,119,129,136,148,166,170,207,211],"group":[13],"IV":[14],"cytosolic":[15],"phospholipase":[16],"A(2)alpha":[17],"(cPLA(2)alpha)":[18],"via":[19],"interaction":[20,33,200],"with":[21,105,153,187],"the":[22,31,40,47,84,92,127,134,137,143,149,154,167,193,204,208],"C2":[23,48,209],"domain.":[24],"In":[25,52],"this":[26,53,57],"study,":[27,191],"we":[28],"hypothesized":[29],"that":[30,115],"site":[34,201],"for":[35,73,100,111,162,181,192],"C1P":[36,74,130,163,199],"localized":[38],"cationic":[41,168,205],"beta-groove":[42,206],"(Arg(57),":[43],"Lys(58),":[44],"Arg(59))":[45],"domain":[49,210],"cPLA(2)alpha.":[51,107,189,212],"regard,":[54],"mutants":[55,82,86,110,118,169],"region":[58],"cPLA(2)alpha":[60,120,171],"were":[61],"generated":[62],"(R57A/K58A/R59A,":[63],"R57A/R59A,":[64],"K58A/R59A,":[65,88],"R57A/K58A,":[66],"R57A,":[67],"K58A,":[68],"R59A)":[70],"examined":[72],"affinity":[75,99],"by":[76],"surface":[77],"plasmon":[78],"resonance.":[79],"The":[80,157],"triple":[81],"(R57A/K58A/R59A),":[83],"double":[85],"(R57A/R59A,":[87],"R57A/K58A),":[90],"single":[93],"mutant":[94],"(R59A)":[95],"significantly":[97,141],"reduced":[98],"C1P-containing":[101],"vesicles":[102],"as":[103,151,164,176,178,185],"compared":[104,152,186],"wild-type":[106,155,188],"Examining":[108],"these":[109,116],"enzymatic":[112],"activity":[113,175],"five":[117],"also":[121],"showed":[122],"significant":[124],"reduction":[125],"in":[126],"ability":[128],"to:":[131],"1)":[132],"increase":[133],"V(max)":[135],"reaction;":[138],"2)":[140],"decrease":[142],"dissociation":[144],"constant":[145],"(K":[146],"(A)(s))":[147],"reaction":[150],"enzyme.":[156],"mutational":[158],"effect":[159],"all":[165],"normal":[173,179],"basal":[174],"well":[177],"affinities":[180],"phosphatidylcholine":[182],"phosphatidylinositol-4,5-bisphosphate":[184],"This":[190],"first":[194],"time,":[195],"demonstrates":[196],"novel":[198],"mapped":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}