{"id":"https://openalex.org/W2002002487","doi":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","title":"Treatment of neoplastic meningeal xenografts by intraventricular administration of an antiganglioside monoclonal antibody, 3F8","display_name":"Treatment of neoplastic meningeal xenografts by intraventricular administration of an antiganglioside monoclonal antibody, 3F8","publication_year":1999,"publication_date":"1999-08-12","ids":{"openalex":"https://openalex.org/W2002002487","doi":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","mag":"2002002487","pmid":"https://pubmed.ncbi.nlm.nih.gov/10404068"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819990812%2982%3A4%3C538%3A%3AAID-IJC12%3E3.0.CO%3B2-7","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819990812%2982%3A4%3C538%3A%3AAID-IJC12%3E3.0.CO%3B2-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013107164","display_name":"Ira Bergman","orcid":"https://orcid.org/0000-0002-9652-7442","observed_orcids":["https://orcid.org/0000-0002-9652-7442"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ira Bergman","raw_affiliation_strings":["Departments of Pediatrics and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. bergmai@chplink.chp.edu","Departments of Pediatrics and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. bergmai@chplink.chp.edu","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Departments of Pediatrics and Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023733504","display_name":"Mamdouha A. Barmada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mamdouha A. Barmada","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031035765","display_name":"Glenn Heller","orcid":"https://orcid.org/0000-0001-9217-8348","observed_orcids":["https://orcid.org/0000-0001-9217-8348"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn Heller","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","Department of Epidemiology & Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051572724","display_name":"Judith A. Griffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith A. Griffin","raw_affiliation_strings":["Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennyslvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, Pennyslvania, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034081882","display_name":"Nai\u2010Kong V. Cheung","orcid":"https://orcid.org/0000-0001-6323-5171","observed_orcids":["https://orcid.org/0000-0001-6323-5171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nai-Kong V. Cheung","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013107164"],"corresponding_institution_ids":["https://openalex.org/I4210134769"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.541,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80609323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"4","first_page":"538","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.38530001044273376,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.38530001044273376,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.33469998836517334,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.18209999799728394,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gd2","display_name":"GD2","score":0.8539999723434448},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.671999990940094},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intraventricular-administration","display_name":"intraventricular administration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9100000262260437},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.796999990940094},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.847000002861023},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7600871324539185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6648200154304504},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5104485750198364},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4492638111114502},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25307604670524597}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011923","descriptor_name":"Rats, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054633","descriptor_name":"Receptor-Like Protein Tyrosine Phosphatases, Class 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819990812%2982%3A4%3C538%3A%3AAID-IJC12%3E3.0.CO%3B2-7","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.3.co;2-z","doi":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.3.co;2-z","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.3.co;2-z","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:10404068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10404068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819990812%2982%3A4%3C538%3A%3AAID-IJC12%3E3.0.CO%3B2-7","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337660","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002002487.pdf","grobid_xml":"https://content.openalex.org/works/W2002002487.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W129444077","https://openalex.org/W135704281","https://openalex.org/W179064617","https://openalex.org/W316863601","https://openalex.org/W1569506030","https://openalex.org/W1608327333","https://openalex.org/W1630308865","https://openalex.org/W1758459798","https://openalex.org/W1933777916","https://openalex.org/W1959949758","https://openalex.org/W1968788742","https://openalex.org/W1974592437","https://openalex.org/W1980668412","https://openalex.org/W1991259695","https://openalex.org/W2002045565","https://openalex.org/W2013042426","https://openalex.org/W2013169107","https://openalex.org/W2028096995","https://openalex.org/W2036143347","https://openalex.org/W2040984433","https://openalex.org/W2042279412","https://openalex.org/W2045068005","https://openalex.org/W2048065547","https://openalex.org/W2057046274","https://openalex.org/W2058720223","https://openalex.org/W2070608888","https://openalex.org/W2076055380","https://openalex.org/W2079347091","https://openalex.org/W2101346560","https://openalex.org/W2107168585","https://openalex.org/W2117419620","https://openalex.org/W2122330550","https://openalex.org/W2141180994","https://openalex.org/W2152982472","https://openalex.org/W2164286199","https://openalex.org/W2167590613","https://openalex.org/W2169462524","https://openalex.org/W2312188128","https://openalex.org/W2333367710","https://openalex.org/W2413436341"],"related_works":["https://openalex.org/W2042279412","https://openalex.org/W1951179504","https://openalex.org/W323673244","https://openalex.org/W1970865970","https://openalex.org/W1968788742","https://openalex.org/W2081598067","https://openalex.org/W4253635688","https://openalex.org/W1972944678","https://openalex.org/W1960710326","https://openalex.org/W2028096995"],"abstract_inverted_index":{"Leptomeningeal":[0],"(LM)":[1],"neoplastic":[2],"metastases":[3],"are":[4],"painful,":[5],"debilitating":[6],"and":[7,35,87,95,129,214,223],"inevitably":[8],"lethal.":[9],"Intrathecal":[10],"(IT)":[11],"anti-tumor":[12],"antibodies":[13],"may":[14],"have":[15],"therapeutic":[16],"potential.":[17],"We":[18,195],"evaluated":[19],"3F8,":[20],"an":[21],"anti-G(D2)":[22,201],"murine":[23],"IgG(3)":[24],"monoclonal":[25],"antibody":[26],"(MAb)":[27],"in":[28,39,47,51,117,122,152],"the":[29,52,142,153,219],"treatment":[30],"of":[31,54,85,124,131,138,161,175,183,187,191,216,226],"human":[32,69],"melanoma":[33],"(SKMEL-1)":[34],"neuroblastoma":[36],"(NMB7)":[37],"xenografts":[38,99,140],"athymic":[40],"rats.":[41],"Both":[42],"tumors":[43],"were":[44,144],"lysed":[45],"efficiently":[46],"vitro":[48],"by":[49,67],"3F8":[50,86,101,176],"presence":[53],"rat":[55,58,74],"neutrophils":[56,205,217],"or":[57,77,105,111],"complement.":[59],"Antibody-dependent":[60],"cellular":[61],"cytotoxicity":[62],"(ADCC)":[63],"was":[64,119,170],"not":[65],"augmented":[66],"recombinant":[68,73],"GM-CSF":[70],"(rhGM-CSF),":[71],"rhG-CSF,":[72],"MIP-2":[75],"(rrMIP-2)":[76],"lipopolysaccharide":[78],"(LPS).":[79],"In":[80],"vivo,":[81],"continuous":[82],"intraventricular":[83,159,173],"administration":[84],"LPS":[88,103,108,162],"prevented":[89,121],"tumor":[90,93,151,188,209,229],"engraftment,":[91],"retarded":[92],"growth":[94],"eradicated":[96,145],"3-day-old":[97],"established":[98,139],"whereas":[100],"alone,":[102],"alone":[104],"F(ab)'(2)":[106],"plus":[107],"had":[109,149],"no":[110],"only":[112],"marginal":[113],"effects.":[114],"Tumor":[115],"establishment":[116],"brain":[118,143,185],"completely":[120],"36%":[123],"animals":[125,132,148],"implanted":[126,133],"with":[127,134,200],"SKMEL-1":[128],"65%":[130],"NMB7.":[135],"Twenty":[136],"percent":[137],"around":[141],"but":[146,189],"all":[147],"persistent":[150,184],"lumbosacral":[154,193],"meninges":[155],"despite":[156],"treatment.":[157],"Continuous":[158,172],"infusion":[160,174],"produced":[163,177],"a":[164],"variable":[165],"polymorphonuclear":[166],"(PMN)":[167],"pleocytosis":[168],"that":[169,197],"dose-dependent.":[171],"immunohistochemically":[178],"detectable":[179],"attachment":[180],"to":[181,206,228],"86%":[182],"deposits":[186],"<1%":[190],"spinal":[192],"deposits.":[194],"conclude":[196],"regional":[198],"therapy":[199],"MAb":[202,227],"could":[203],"target":[204],"inhibit":[207],"LM":[208],"growth.":[210],"However,":[211],"optimal":[212],"activation":[213],"mobilization":[215],"into":[218],"cerebrospinal":[220],"fluid":[221],"(CSF)":[222],"improved":[224],"penetration":[225],"sites":[230],"remain":[231],"critical":[232],"variables.":[233]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
