{"id":"https://openalex.org/W2001978617","doi":"https://doi.org/10.7314/apjcp.2012.13.8.4075","title":"Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines","display_name":"Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines","publication_year":2012,"publication_date":"2012-08-31","ids":{"openalex":"https://openalex.org/W2001978617","doi":"https://doi.org/10.7314/apjcp.2012.13.8.4075","mag":"2001978617","pmid":"https://pubmed.ncbi.nlm.nih.gov/23098519"},"language":"en","primary_location":{"id":"doi:10.7314/apjcp.2012.13.8.4075","doi":"https://doi.org/10.7314/apjcp.2012.13.8.4075","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2012.13.8.4075","pdf_url":"http://koreascience.or.kr:80/article/JAKO201202950482617.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://koreascience.or.kr:80/article/JAKO201202950482617.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014248083","display_name":"Mohammed Hadi Al\u2013Douh","orcid":"https://orcid.org/0000-0001-9777-2653","observed_orcids":["https://orcid.org/0000-0001-9777-2653"]},"institutions":[{"id":"https://openalex.org/I319841309","display_name":"Hadhramout University","ror":"https://ror.org/02kv0px94","country_code":"YE","type":"education","lineage":["https://openalex.org/I319841309"]}],"countries":["YE"],"is_corresponding":false,"raw_author_name":"Mohammed Hadi Al-Douh","raw_affiliation_strings":["Chemistry Department, Faculty of Science, Hadhramout University of Science and Technology (HUST), Mukalla, Hadhramout, Yemen. mhd_douh@yahoo.com","Chemistry Department, Faculty of Science, Hadhramout University of Science and Technology (HUST), Mukalla, Hadhramout, Yemen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Hadhramout University of Science and Technology (HUST), Mukalla, Hadhramout, Yemen. mhd_douh@yahoo.com","institution_ids":["https://openalex.org/I319841309"]},{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Hadhramout University of Science and Technology (HUST), Mukalla, Hadhramout, Yemen","institution_ids":["https://openalex.org/I319841309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062496879","display_name":"Hayder B. Sahib","orcid":"https://orcid.org/0000-0002-0939-5622","observed_orcids":["https://orcid.org/0000-0002-0939-5622"]},"institutions":[{"id":"https://openalex.org/I4210142005","display_name":"University of Kerbala","ror":"https://ror.org/0449bkp65","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210142005"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Hayder B. Sahib","raw_affiliation_strings":["Pharmacology Department , College of Pharmacy , Karbala University , Iraq,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department , College of Pharmacy , Karbala University , Iraq,","institution_ids":["https://openalex.org/I4210142005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051256126","display_name":"Hasnah Osman","orcid":"https://orcid.org/0000-0001-8695-470X","observed_orcids":["https://orcid.org/0000-0001-8695-470X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hasnah Osman","raw_affiliation_strings":["School of Chemical Sciences ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044558265","display_name":"Shafida Abd Hamid","orcid":"https://orcid.org/0000-0002-2658-1216","observed_orcids":["https://orcid.org/0000-0002-2658-1216"]},"institutions":[{"id":"https://openalex.org/I4164984","display_name":"International Islamic University Malaysia","ror":"https://ror.org/03s9hs139","country_code":"MY","type":"education","lineage":["https://openalex.org/I4164984"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Shafida Abd Hamid","raw_affiliation_strings":["Kulliyyah of Science , International Islamic University Malaysia (IIUM) , Pahang , Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kulliyyah of Science , International Islamic University Malaysia (IIUM) , Pahang , Malaysia","institution_ids":["https://openalex.org/I4164984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069444895","display_name":"Salizawati Muhamad Salhimi","orcid":"https://orcid.org/0000-0002-5926-4524","observed_orcids":["https://orcid.org/0000-0002-5926-4524"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Salizawati M. Salhimi","raw_affiliation_strings":["School of Pharmaceutical Sciences , Universiti Sains Malaysia (USM) , Pulau Pinang ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences , Universiti Sains Malaysia (USM) , Pulau Pinang ,","institution_ids":["https://openalex.org/I139322472"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.2734,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.48641497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"13","issue":"8","first_page":"4075","last_page":"4079"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzimidazole-derivatives","display_name":"benzimidazole derivatives","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.7570000290870667},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2778484023","wikidata":"https://www.wikidata.org/wiki/Q415190","display_name":"Benzimidazole","level":2,"score":0.9685836434364319},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.8878178000450134},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5589451789855957},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5358976125717163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4897487163543701},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.4336813986301422},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4271138906478882},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4239594042301178},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.380471408367157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35612714290618896},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34683895111083984},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.26286014914512634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20973578095436096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1859963834285736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1859818398952484},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.17038178443908691},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7314/apjcp.2012.13.8.4075","doi":"https://doi.org/10.7314/apjcp.2012.13.8.4075","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2012.13.8.4075","pdf_url":"http://koreascience.or.kr:80/article/JAKO201202950482617.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmid:23098519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23098519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7314/apjcp.2012.13.8.4075","doi":"https://doi.org/10.7314/apjcp.2012.13.8.4075","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2012.13.8.4075","pdf_url":"http://koreascience.or.kr:80/article/JAKO201202950482617.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322757","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2001978617.pdf","grobid_xml":"https://content.openalex.org/works/W2001978617.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W592342571","https://openalex.org/W1971573878","https://openalex.org/W1972586991","https://openalex.org/W1974793456","https://openalex.org/W1983255887","https://openalex.org/W1983974652","https://openalex.org/W1985426723","https://openalex.org/W1993855901","https://openalex.org/W2007468850","https://openalex.org/W2011421379","https://openalex.org/W2012060632","https://openalex.org/W2013760968","https://openalex.org/W2018879164","https://openalex.org/W2021210557","https://openalex.org/W2022324133","https://openalex.org/W2030363558","https://openalex.org/W2032867733","https://openalex.org/W2063443576","https://openalex.org/W2068859588","https://openalex.org/W2077022475","https://openalex.org/W2084199566","https://openalex.org/W2086726544","https://openalex.org/W2088185537","https://openalex.org/W2089593770","https://openalex.org/W2091370224","https://openalex.org/W2114918609","https://openalex.org/W2126913162","https://openalex.org/W2128984725","https://openalex.org/W2135486341","https://openalex.org/W2153527675","https://openalex.org/W2156548893","https://openalex.org/W2173513623","https://openalex.org/W2176255757"],"related_works":["https://openalex.org/W4389022111","https://openalex.org/W2754148226","https://openalex.org/W3093256208","https://openalex.org/W3162372006","https://openalex.org/W7201975514","https://openalex.org/W2743091213","https://openalex.org/W2317719334","https://openalex.org/W2592735112","https://openalex.org/W4407849831","https://openalex.org/W7203571405"],"abstract_inverted_index":{"Benzimidazoles":[0],"1-4":[1],"were":[2],"obtained":[3],"using":[4,27],"modified":[5],"synthesis":[6],"methods":[7],"and":[8,22,49,94,135],"studied":[9],"for":[10,61,130],"their":[11],"ability":[12],"to":[13,39],"inhibit":[14],"cell":[15,20,25,33,72,113],"proliferation":[16],"of":[17,44,54,80,89,99,111,132],"colon":[18,134],"cancer":[19,24],"HCT-116":[21,32],"breast":[23,136],"MCF-7":[26,71],"MTT":[28],"assays.":[29],"In":[30,69],"the":[31,70,112],"line,":[34,73],"benzimidazole":[35,50,62,74,85,95],"2":[36,86],"was":[37,64],"found":[38],"have":[40,127],"an":[41,77],"IC50":[42,78,116],"value":[43,53,79,88,98],"16.2":[45],"\u00b1":[46,56,66,82,91,101],"3.85":[47],"\u03bcg/mL":[48],"1":[51,96],"a":[52,87,97],"28.5":[55],"2.91":[57],"\u03bcg/mL,":[58,84,93],"while":[59],"that":[60,123],"4":[63,75],"24.08":[65],"0.31":[67],"\u03bcg/mL.":[68,103,119],"had":[76],"8.86":[81],"1.10":[83],"30.29":[90],"6.39":[92],"31.2":[100],"4.49":[102],"Benzimidazole":[104],"3":[105],"exerted":[106],"no":[107],"cytotoxicity":[108],"in":[109],"either":[110],"lines,":[114],"with":[115],"values":[117],">50":[118],"The":[120],"results":[121],"suggest":[122],"benzimidazoles":[124],"derivatives":[125],"may":[126],"chemotherapeutic":[128],"potential":[129],"treatment":[131],"both":[133],"cancers.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}