{"id":"https://openalex.org/W2001800548","doi":"https://doi.org/10.1021/ja070683j","title":"Substrate- and Isoform-Specific Dioxygen Complexes of Nitric Oxide Synthase","display_name":"Substrate- and Isoform-Specific Dioxygen Complexes of Nitric Oxide Synthase","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2001800548","doi":"https://doi.org/10.1021/ja070683j","mag":"2001800548","pmid":"https://pubmed.ncbi.nlm.nih.gov/17488012"},"language":"en","primary_location":{"id":"doi:10.1021/ja070683j","doi":"https://doi.org/10.1021/ja070683j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja070683j","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100432955","display_name":"David Xinzheyang Li","orcid":"https://orcid.org/0000-0002-1028-8445","observed_orcids":["https://orcid.org/0000-0002-1028-8445"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Li","raw_affiliation_strings":["Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1316902750","https://openalex.org/I19772626","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mariam Kabir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariam Kabir","raw_affiliation_strings":["Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1316902750","https://openalex.org/I19772626","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067430639","display_name":"Dennis J. Stuehr","orcid":"https://orcid.org/0000-0002-0960-6848","observed_orcids":["https://orcid.org/0000-0002-0960-6848"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis J. Stuehr","raw_affiliation_strings":["Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1316902750","https://openalex.org/I19772626","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006206064","display_name":"Denis L. Rousseau","orcid":"https://orcid.org/0000-0001-5405-5128","observed_orcids":["https://orcid.org/0000-0001-5405-5128"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denis L. Rousseau","raw_affiliation_strings":["Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1316902750","https://openalex.org/I19772626","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059629802","display_name":"Syun\u2010Ru Yeh","orcid":"https://orcid.org/0000-0002-9858-386X","observed_orcids":["https://orcid.org/0000-0002-9858-386X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syun-Ru Yeh","raw_affiliation_strings":["Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, and Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1316902750","https://openalex.org/I19772626","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.6459,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.9497787,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"129","issue":"21","first_page":"6943","last_page":"6951"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dioxygen-complexes","display_name":"dioxygen complexes","score":0.7139999866485596},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/peroxy-intermediate","display_name":"peroxy intermediate","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.5730000138282776},{"id":"https://openalex.org/keywords/resonance-raman-spectroscopy","display_name":"resonance Raman spectroscopy","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9542791843414307},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.7092439532279968},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.7030853629112244},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6706367135047913},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6012643575668335},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.5423804521560669},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4791814088821411},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.4684968590736389},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.41789379715919495},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4054262340068817},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37565526366233826},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.34733301401138306},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.33504483103752136},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15148431062698364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11878529191017151},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11693495512008667},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja070683j","doi":"https://doi.org/10.1021/ja070683j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja070683j","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:17488012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17488012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1934500543","display_name":null,"funder_award_id":"CA-53914","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2094394703","display_name":"Molecular Biophysics Training Grant","funder_award_id":"5t32gm008572-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2978160290","display_name":"Structure Function Relationship in Hemeproteins","funder_award_id":"R01HL065465","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3239202092","display_name":null,"funder_award_id":"HL65465","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3487437694","display_name":null,"funder_award_id":"GM 54806","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5693421086","display_name":null,"funder_award_id":"GM08572","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5949373188","display_name":null,"funder_award_id":"GM51491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7421843679","display_name":"Catalytic Mechanisms and Properties of Heme Proteins","funder_award_id":"R01GM054806","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7542777358","display_name":"Control Mechanisms of the Nitric Oxide Synthases","funder_award_id":"R01GM051491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G87033130","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007288","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G929954751","display_name":null,"funder_award_id":"GM07288","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W623898972","https://openalex.org/W1479676079","https://openalex.org/W1487443561","https://openalex.org/W1526609551","https://openalex.org/W1599900714","https://openalex.org/W1800678382","https://openalex.org/W1964075597","https://openalex.org/W1964699255","https://openalex.org/W1966165983","https://openalex.org/W1973018387","https://openalex.org/W1973810709","https://openalex.org/W1975262546","https://openalex.org/W1976406874","https://openalex.org/W1977436777","https://openalex.org/W1979363917","https://openalex.org/W1979476125","https://openalex.org/W1979784283","https://openalex.org/W1982420679","https://openalex.org/W1983538003","https://openalex.org/W1983951183","https://openalex.org/W1985880026","https://openalex.org/W1988349199","https://openalex.org/W2005083492","https://openalex.org/W2025970565","https://openalex.org/W2040789640","https://openalex.org/W2045639174","https://openalex.org/W2053688565","https://openalex.org/W2068124482","https://openalex.org/W2076973248","https://openalex.org/W2079639940","https://openalex.org/W2080028159","https://openalex.org/W2086948567","https://openalex.org/W2092939065","https://openalex.org/W2094354723","https://openalex.org/W2110343235","https://openalex.org/W2115153703","https://openalex.org/W2140158011","https://openalex.org/W2158355537","https://openalex.org/W2583819155","https://openalex.org/W3137224270"],"related_works":["https://openalex.org/W2085048960","https://openalex.org/W1964699255","https://openalex.org/W2050414004","https://openalex.org/W2040407936","https://openalex.org/W2058366028","https://openalex.org/W2053154146","https://openalex.org/W2110343235","https://openalex.org/W3101150153","https://openalex.org/W2076973248","https://openalex.org/W2045814548"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1,37],"synthase":[2],"(NOS)":[3],"catalyzes":[4],"the":[5,15,26,41,45,49,67,71,76,85,90,101,122,127,133,138,147,150,163,168,180,183,188,192,194,197,200,205,208,216,219,222,226,230,232,235,238,245,255],"formation":[6,206],"of":[7,48,70,75,79,89,103,113,126,135,149,167,182,191,199,207,218,229,234],"NO":[8],"via":[9],"a":[10,59,144,175,250],"consecutive":[11],"two-step":[12],"reaction.":[13],"In":[14,25,131,187],"first":[16,189],"step,":[17,28],"L-arginine":[18],"(Arg)":[19],"is":[20,30,98,158,213],"converted":[21,32],"to":[22,33,65,100,108,118,121,137,204,254],"N-hydroxy-L-arginine":[23],"(NOHA).":[24],"second":[27,227],"NOHA":[29,136],"further":[31],"citrulline":[34],"and":[35],"nitric":[36],"(NO).":[38],"To":[39],"assess":[40],"mechanistic":[42],"differences":[43],"between":[44],"two":[46],"steps":[47],"reaction,":[50,193,231],"we":[51,116],"have":[52],"used":[53],"resonance":[54],"Raman":[55],"spectroscopy":[56],"combined":[57],"with":[58,162],"homemade":[60],"continuous-flow":[61],"rapid":[62],"solution":[63],"mixer":[64],"study":[66],"structural":[68],"properties":[69],"metastable":[72],"dioxygen-bound":[73],"complexes":[74],"oxygenase":[77],"domain":[78],"inducible":[80],"NOS":[81],"(iNOSoxy).":[82],"We":[83],"identified":[84],"O-O":[86,151,201,240],"stretching":[87,152],"frequency":[88,97,148],"substrate-free":[91],"enzyme":[92,139],"at":[93],"1133":[94],"cm-1.":[95],"This":[96],"insensitive":[99],"presence":[102],"tetrahydrobiopterin,":[104],"but":[105],"it":[106],"shifts":[107],"1126":[109],"cm-1":[110],"upon":[111],"binding":[112],"Arg,":[114,156],"which":[115,212],"attribute":[117],"H-bonding":[119,172],"interactions":[120,173],"terminal":[123,164],"oxygen":[124,165],"atom":[125,166],"heme":[128],"iron-bound":[129],"dioxygen.":[130,169],"contrast,":[132],"addition":[134,252],"did":[140],"not":[141],"bring":[142],"about":[143],"shift":[145],"in":[146,178,225],"mode,":[153],"because,":[154],"unlike":[155],"there":[157],"no":[159],"H-bond":[160],"associated":[161],"The":[170],"substrate-specific":[171],"play":[174],"critical":[176],"role":[177],"determining":[179],"fate":[181],"key":[184],"peroxy":[185,246],"intermediate.":[186],"step":[190,228],"H-bonds":[195,236],"facilitate":[196],"rupture":[198],"bond,":[202],"leading":[203],"active":[209],"ferryl":[210],"species,":[211],"essential":[214],"for":[215],"oxidation":[217],"Arg.":[220],"On":[221],"other":[223],"hand,":[224],"absence":[233],"prevents":[237],"premature":[239],"bond":[241],"cleavage,":[242],"such":[243],"that":[244],"intermediate":[247],"can":[248],"perform":[249],"nucleophilic":[251],"reaction":[253],"substrate,":[256],"NOHA.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
