{"id":"https://openalex.org/W2001766071","doi":"https://doi.org/10.1039/b719423d","title":"A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues","display_name":"A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues","publication_year":2008,"publication_date":"2008-04-29","ids":{"openalex":"https://openalex.org/W2001766071","doi":"https://doi.org/10.1039/b719423d","mag":"2001766071","pmid":"https://pubmed.ncbi.nlm.nih.gov/18493648"},"language":"en","primary_location":{"id":"doi:10.1039/b719423d","doi":"https://doi.org/10.1039/b719423d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b719423d","pdf_url":null,"source":{"id":"https://openalex.org/S169293703","display_name":"Molecular BioSystems","issn_l":"1742-2051","issn":["1742-2051","1742-206X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular BioSystems","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050675899","display_name":"Irene Kiburu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Kiburu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007473514","display_name":"Andrew J. Shurer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Shurer","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087200932","display_name":"Lei Yan","orcid":"https://orcid.org/0000-0003-2596-6840","observed_orcids":["https://orcid.org/0000-0003-2596-6840"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Yan","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037299132","display_name":"Herman O. Sintim","orcid":"https://orcid.org/0000-0002-2280-9359","observed_orcids":["https://orcid.org/0000-0002-2280-9359"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herman O Sintim","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland a , College Park, MD 20742, USA \u00a0 hsintim@umd.edu \u00a0 +113013149121 \u00a0 +113014050633","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, USA","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037299132"],"corresponding_institution_ids":["https://openalex.org/I66946132"],"apc_list":null,"apc_paid":null,"fwci":1.644,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.81970589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"6","first_page":"518","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.19359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.12470000237226486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-di-gmp","display_name":"c-di-GMP","score":0.7379999756813049},{"id":"https://openalex.org/keywords/solid-phase-synthesis","display_name":"solid-phase synthesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/automated-dna-synthesis","display_name":"automated DNA synthesis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/bacterial-signaling-molecules","display_name":"bacterial signaling molecules","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cyclic-nucleotides","display_name":"cyclic nucleotides","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.5534011125564575},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.5316950082778931},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5159748196601868},{"id":"https://openalex.org/C3020139451","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic gmp","level":3,"score":0.4959736764431},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4649563729763031},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4596608877182007},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4393998980522156},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.429617702960968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3088824152946472},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28962278366088867},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12524747848510742},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08537295460700989},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003500","descriptor_name":"Cyclization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/b719423d","doi":"https://doi.org/10.1039/b719423d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b719423d","pdf_url":null,"source":{"id":"https://openalex.org/S169293703","display_name":"Molecular BioSystems","issn_l":"1742-2051","issn":["1742-2051","1742-206X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-100"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular BioSystems","raw_type":"journal-article"},{"id":"pmid:18493648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18493648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular bioSystems","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1971007680","https://openalex.org/W1987101128","https://openalex.org/W1987931782","https://openalex.org/W2010225828","https://openalex.org/W2010466313","https://openalex.org/W2024534479","https://openalex.org/W2039404107","https://openalex.org/W2041355006","https://openalex.org/W2043082285","https://openalex.org/W2045347894","https://openalex.org/W2048874154","https://openalex.org/W2061036236","https://openalex.org/W2064223462","https://openalex.org/W2087017025","https://openalex.org/W2087803307","https://openalex.org/W2095209497","https://openalex.org/W2110451936","https://openalex.org/W2119129131","https://openalex.org/W2122674147","https://openalex.org/W2142637309","https://openalex.org/W2145131996","https://openalex.org/W2145792008","https://openalex.org/W2155604981","https://openalex.org/W2156788471","https://openalex.org/W2313752598"],"related_works":["https://openalex.org/W4364353494","https://openalex.org/W2952726148","https://openalex.org/W7100736526","https://openalex.org/W2030383675","https://openalex.org/W2259684565","https://openalex.org/W2027931768","https://openalex.org/W2048686249","https://openalex.org/W2754801914","https://openalex.org/W2324489554","https://openalex.org/W2290506367"],"abstract_inverted_index":{"Cyclic-di-guanylate":[0],"(c-di-GMP)":[1],"has":[2],"emerged":[3],"as":[4],"a":[5,18],"general":[6],"and":[7],"important":[8],"signaling":[9],"molecule":[10],"uniquely":[11],"present":[12],"in":[13],"bacteria:":[14],"herein":[15],"we":[16],"provide":[17],"simple":[19],"solid-phase":[20],"synthesis":[21],"of":[22,32],"c-di-GMP":[23],"using":[24],"an":[25],"automated":[26],"DNA":[27],"synthesizer":[28],"for":[29],"the":[30,33],"majority":[31],"synthesis.":[34]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
