{"id":"https://openalex.org/W2001724680","doi":"https://doi.org/10.1016/s0272-0590(81)80041-3","title":"Assessment of hepatic function in rabbits with steroid-induced cholestatic liver injury1","display_name":"Assessment of hepatic function in rabbits with steroid-induced cholestatic liver injury1","publication_year":1981,"publication_date":"1981-07-01","ids":{"openalex":"https://openalex.org/W2001724680","doi":"https://doi.org/10.1016/s0272-0590(81)80041-3","mag":"2001724680","pmid":"https://pubmed.ncbi.nlm.nih.gov/6136444"},"language":"en","primary_location":{"id":"doi:10.1016/s0272-0590(81)80041-3","doi":"https://doi.org/10.1016/s0272-0590(81)80041-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0272-0590(81)80041-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210177754","display_name":"Fundamental and Applied Toxicology","issn_l":"0272-0590","issn":["0272-0590","1095-6832"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental and Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048944606","display_name":"Bryn Tennant","orcid":"https://orcid.org/0000-0001-5818-9254","observed_orcids":["https://orcid.org/0000-0001-5818-9254"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B TENNANT","raw_affiliation_strings":["Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073532534","display_name":"Tibor Bal\u00e1zs","orcid":"https://orcid.org/0000-0001-7966-2987","observed_orcids":["https://orcid.org/0000-0001-7966-2987"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T BALAZS","raw_affiliation_strings":["Drug Toxicology Branch, Bureau of Drugs, Food and Drug Administration, Washington, DC 20204, USA","Drug Toxicology Branch, Bureau of Drugs, Food and Drug AdministrationWashington, DC 20204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Toxicology Branch, Bureau of Drugs, Food and Drug Administration, Washington, DC 20204, USA","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Drug Toxicology Branch, Bureau of Drugs, Food and Drug AdministrationWashington, DC 20204","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B BALDWIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B BALDWIN","raw_affiliation_strings":["Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111438301","display_name":"William E. Hornbuckle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W HORNBUCKLE","raw_affiliation_strings":["Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046012473","display_name":"William L. Castleman","orcid":"https://orcid.org/0000-0002-2868-346X","observed_orcids":["https://orcid.org/0000-0002-2868-346X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W CASTLEMAN","raw_affiliation_strings":["Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Pathology, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Pathology, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074067636","display_name":"Urs Alex Boelsterli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U BOELSTERLI","raw_affiliation_strings":["Drug Toxicology Branch, Bureau of Drugs, Food and Drug Administration, Washington, DC 20204, USA","Drug Toxicology Branch, Bureau of Drugs, Food and Drug AdministrationWashington, DC 20204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Toxicology Branch, Bureau of Drugs, Food and Drug Administration, Washington, DC 20204, USA","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Drug Toxicology Branch, Bureau of Drugs, Food and Drug AdministrationWashington, DC 20204","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090580659","display_name":"Francis A. Kallfelz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F KALLFELZ","raw_affiliation_strings":["Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell UniversityIthaca, NY 14853","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7117,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.66496221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"1","issue":"4","first_page":"329","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyltestosterone","display_name":"methyltestosterone","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ethinyl-estradiol","display_name":"ethinyl estradiol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatic-function-assessment","display_name":"hepatic function assessment","score":0.6449999809265137},{"id":"https://openalex.org/keywords/serum-gamma-glutamyltransferase","display_name":"serum gamma-glutamyltransferase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bile-acid-excretion","display_name":"bile acid excretion","score":0.7419999837875366},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.734000027179718},{"id":"https://openalex.org/keywords/bile-duct-proliferation","display_name":"bile duct proliferation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/portal-inflammation","display_name":"portal inflammation","score":0.593999981880188},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8014076948165894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7128898501396179},{"id":"https://openalex.org/C2778586440","wikidata":"https://www.wikidata.org/wiki/Q421768","display_name":"Methyltestosterone","level":2,"score":0.6514334678649902},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6023245453834534},{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.519516110420227},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.4998013973236084},{"id":"https://openalex.org/C167464567","wikidata":"https://www.wikidata.org/wiki/Q1775422","display_name":"Mononuclear cell infiltration","level":2,"score":0.46886593103408813},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.4590306580066681},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.454216331243515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4496418535709381},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3435036540031433},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17238375544548035},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15137320756912231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004997","descriptor_name":"Ethinyl Estradiol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008777","descriptor_name":"Methyltestosterone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0272-0590(81)80041-3","doi":"https://doi.org/10.1016/s0272-0590(81)80041-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0272-0590(81)80041-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210177754","display_name":"Fundamental and Applied Toxicology","issn_l":"0272-0590","issn":["0272-0590","1095-6832"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental and Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:6136444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6136444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental and applied toxicology : official journal of the Society of Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W12106605","https://openalex.org/W1662999722","https://openalex.org/W1858182200","https://openalex.org/W1869666960","https://openalex.org/W1905635323","https://openalex.org/W1973780799","https://openalex.org/W1981956321","https://openalex.org/W1982191669","https://openalex.org/W2027486952","https://openalex.org/W2035345170","https://openalex.org/W2041426207","https://openalex.org/W2052995578","https://openalex.org/W2056956938","https://openalex.org/W2061554884","https://openalex.org/W2063849519","https://openalex.org/W2064870875","https://openalex.org/W2067176761","https://openalex.org/W2069798088","https://openalex.org/W2074964632","https://openalex.org/W2095219797","https://openalex.org/W2106153031","https://openalex.org/W2121975223","https://openalex.org/W2126634169","https://openalex.org/W2150171491","https://openalex.org/W2169796124","https://openalex.org/W2313679778","https://openalex.org/W2396897573","https://openalex.org/W2411978698","https://openalex.org/W2412816777","https://openalex.org/W2414193463","https://openalex.org/W2419128896","https://openalex.org/W2898043183"],"related_works":["https://openalex.org/W4254589560","https://openalex.org/W7096510351","https://openalex.org/W2275307548","https://openalex.org/W185091860","https://openalex.org/W2985127393","https://openalex.org/W2037140366","https://openalex.org/W2317900587","https://openalex.org/W4255669888","https://openalex.org/W2438937225","https://openalex.org/W1987474931"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}