{"id":"https://openalex.org/W2001687367","doi":"https://doi.org/10.1113/jphysiol.1974.sp010601","title":"The effect of carbon dioxide in the airways and alveoli on ventilation; a vagal reflex studied in the dog","display_name":"The effect of carbon dioxide in the airways and alveoli on ventilation; a vagal reflex studied in the dog","publication_year":1974,"publication_date":"1974-07-01","ids":{"openalex":"https://openalex.org/W2001687367","doi":"https://doi.org/10.1113/jphysiol.1974.sp010601","mag":"2001687367","pmid":"https://pubmed.ncbi.nlm.nih.gov/4854745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1330983"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1974.sp010601","doi":"https://doi.org/10.1113/jphysiol.1974.sp010601","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1974.sp010601","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1330983/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A. Bartoli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Bartoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017274917","display_name":"Brenda A. Cross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brenda A. Cross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076366400","display_name":"A. Guz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Guz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038808562","display_name":"Sushil Kumar Jain","orcid":"https://orcid.org/0000-0002-9574-0436","observed_orcids":["https://orcid.org/0000-0002-9574-0436","https://orcid.org/0009-0009-5772-5786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. K. Jain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075479975","display_name":"Mark I. M. Noble","orcid":"https://orcid.org/0000-0002-1481-3198","observed_orcids":["https://orcid.org/0000-0002-1481-3198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. I. M. Noble","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024159489","display_name":"Diana W. Trenchard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana W. Trenchard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":8.367,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.99182561,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"240","issue":"1","first_page":"91","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-dioxide","display_name":"carbon dioxide","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tachypnea","display_name":"tachypnea","score":0.906000018119812},{"id":"https://openalex.org/keywords/vagal-reflex","display_name":"vagal reflex","score":0.9079999923706055},{"id":"https://openalex.org/keywords/respiratory-control","display_name":"respiratory control","score":0.40400001406669617},{"id":"https://openalex.org/keywords/alveolar-carbon-dioxide-tension","display_name":"alveolar carbon dioxide tension","score":0.6589999794960022},{"id":"https://openalex.org/keywords/expiratory-time","display_name":"expiratory time","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"tidal volume","score":0.984000027179718},{"id":"https://openalex.org/keywords/vagotomy","display_name":"vagotomy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6826749444007874},{"id":"https://openalex.org/C2778720886","wikidata":"https://www.wikidata.org/wiki/Q1417507","display_name":"Vagotomy","level":2,"score":0.67118901014328},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.647024929523468},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5780037045478821},{"id":"https://openalex.org/C2776725644","wikidata":"https://www.wikidata.org/wiki/Q594365","display_name":"Chloralose","level":3,"score":0.5548285245895386},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.5203896760940552},{"id":"https://openalex.org/C115504290","wikidata":"https://www.wikidata.org/wiki/Q7908541","display_name":"Vagovagal reflex","level":3,"score":0.4946124255657196},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.47642406821250916},{"id":"https://openalex.org/C8213797","wikidata":"https://www.wikidata.org/wiki/Q754250","display_name":"Respiratory rate","level":4,"score":0.4694755971431732},{"id":"https://openalex.org/C530467964","wikidata":"https://www.wikidata.org/wiki/Q1997","display_name":"Carbon dioxide","level":2,"score":0.45887672901153564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4402976930141449},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.43833762407302856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4113251566886902},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22035717964172363},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.16855624318122864},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1255766749382019},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10429197549819946},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013147","descriptor_name":"Spirometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014628","descriptor_name":"Vagotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1974.sp010601","doi":"https://doi.org/10.1113/jphysiol.1974.sp010601","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1974.sp010601","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:4854745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4854745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1330983","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1330983/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1330983","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1330983/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1973440483","https://openalex.org/W1982182378","https://openalex.org/W2006046167","https://openalex.org/W2012060177","https://openalex.org/W2013165456","https://openalex.org/W2035550723","https://openalex.org/W2044520352","https://openalex.org/W2046783778","https://openalex.org/W2048440966","https://openalex.org/W2053868363","https://openalex.org/W2054294450","https://openalex.org/W2075938047","https://openalex.org/W2140285237","https://openalex.org/W2171417511","https://openalex.org/W2238877149","https://openalex.org/W2406402094","https://openalex.org/W2407210925","https://openalex.org/W2408032486","https://openalex.org/W2416803909","https://openalex.org/W2470463689","https://openalex.org/W2471248653","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2124484664","https://openalex.org/W2017703120","https://openalex.org/W2037010365","https://openalex.org/W1982182378","https://openalex.org/W2257650749","https://openalex.org/W2415177190","https://openalex.org/W2090253589","https://openalex.org/W2056423665","https://openalex.org/W2295036319","https://openalex.org/W2029116912"],"abstract_inverted_index":{"1.":[0],"The":[1,82,114,132,151,178],"inhalation":[2],"of":[3,12,25,75,84,112,124,153,161,181,193,219],"CO(2)":[4,63,85,162,220],"produces":[5],"a":[6,122,144,212],"tachypnoea":[7],"only":[8],"in":[9,28,36,64,72,86,94,97,116,140,163,169,221],"the":[10,16,23,29,45,58,73,80,90,102,108,159,164,167,170,191,207],"presence":[11],"intact":[13],"vagus":[14],"nerves;":[15],"present":[17],"study":[18],"was":[19,34,47,55,119,134,172,185],"designed":[20],"to":[21,89,121,174,187,190],"examine":[22],"mechanism":[24],"this":[26],"phenomenon":[27],"dog.2.":[30],"Closed-chest":[31],"cardiopulmonary":[32],"bypass":[33],"established":[35,48],"dogs":[37],"weighing":[38],"16-24":[39],"kg,":[40],"anaesthetized":[41],"with":[42],"chloralose.":[43],"When":[44],";bypass'":[46],"pulmonary":[49],"blood":[50,168],"flow":[51],"ceased,":[52],"P(A,":[53],"CO2)":[54,77,156],"reduced":[56],"and":[57,105],"respiratory":[59,98,117],"rate":[60],"slowed.":[61],"3-10%":[62],"O(2)":[65],"could":[66],"then":[67],"be":[68,188],"inhaled":[69],"without":[70],"change":[71],"level":[74],"P(a,":[76,155,195],"set":[78],"at":[79,101],"oxygenator.3.":[81],"addition":[83],"these":[87],"concentrations":[88,218],"inspired":[91],"oxygen":[92],"resulted":[93],"an":[95,201],"increase":[96,115,175],"frequency,":[99],"maximal":[100],"first":[103],"breath":[104],"sustained":[106],"for":[107],"1":[109],"min":[110],"period":[111],"exposure.":[113],"frequency":[118],"due":[120],"shortening":[123],"expiratory":[125],"duration.":[126],"Inspiratory":[127],"duration":[128],"did":[129],"not":[130],"change.":[131],"response":[133],"absent":[135],"after":[136],"vagotomy.4.":[137],"Inert":[138],"gases":[139],"O(2),":[141],"given":[142],"as":[143],"control,":[145],"had":[146],"no":[147],"effect":[148,152,180,192],"on":[149,214],"breathing.5.":[150],"raising":[154,194],"(by":[157],"increasing":[158],"concentration":[160],"gas":[165],"equilibrating":[166],"oxygenator),":[171],"primarily":[173],"tidal":[176],"volume.6.":[177],"ventilatory":[179],"inspiring":[182],"CO(2)/O(2)":[183],"mixtures":[184],"shown":[186],"additive":[189],"CO2).7.":[196],"These":[197],"experiments":[198],"show":[199],"that":[200],"afferent":[202],"vagal":[203],"reflex":[204],"originating":[205],"from":[206],"lungs":[208],"causes":[209],"tachypnoea,":[210],"when":[211],"dog,":[213],";bypass',":[215],"inhales":[216],"low":[217],"O(2).":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}