{"id":"https://openalex.org/W2001501946","doi":"https://doi.org/10.1371/journal.pone.0077605","title":"Innate Immune Signaling Induces Interleukin-7 Production from Salivary Gland Cells and Accelerates the Development of Primary Sj\u04e7gren\u2019s Syndrome in a Mouse Model","display_name":"Innate Immune Signaling Induces Interleukin-7 Production from Salivary Gland Cells and Accelerates the Development of Primary Sj\u04e7gren\u2019s Syndrome in a Mouse Model","publication_year":2013,"publication_date":"2013-10-17","ids":{"openalex":"https://openalex.org/W2001501946","doi":"https://doi.org/10.1371/journal.pone.0077605","mag":"2001501946","pmid":"https://pubmed.ncbi.nlm.nih.gov/24147035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3798297"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0077605","doi":"https://doi.org/10.1371/journal.pone.0077605","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0077605","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0077605&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0077605&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052419517","display_name":"Jun\u2010O Jin","orcid":"https://orcid.org/0000-0003-4216-8111","observed_orcids":["https://orcid.org/0000-0003-4216-8111"]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun-O Jin","raw_affiliation_strings":["Department of Immunology and Infectious Disease, the Forsyth Institute, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Disease, the Forsyth Institute, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4405268108"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshinori Shinohara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Shinohara","raw_affiliation_strings":["Division of Oral Rehabilitation, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oral Rehabilitation, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000208362","display_name":"Qing Yu","orcid":"https://orcid.org/0000-0002-5818-0564","observed_orcids":["https://orcid.org/0000-0002-5818-0564"]},"institutions":[{"id":"https://openalex.org/I4405268108","display_name":"The Forsyth Institute","ror":"https://ror.org/05tr9gt18","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405268108"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qing Yu","raw_affiliation_strings":["Department of Immunology and Infectious Disease, the Forsyth Institute, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Disease, the Forsyth Institute, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4405268108"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000208362"],"corresponding_institution_ids":["https://openalex.org/I4405268108"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.7261,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92974182,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"10","first_page":"e77605","last_page":"e77605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sjogren-syndrome","display_name":"primary Sj\u00f6gren's syndrome","score":0.9129999876022339},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.9950000047683716},{"id":"https://openalex.org/keywords/innate-immune-signaling","display_name":"innate immune signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.7789999842643738},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.8650000095367432},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8769999742507935},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.9599999785423279},{"id":"https://openalex.org/keywords/il-7-receptor","display_name":"IL-7 receptor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/salivary-gland-epithelial-cells","display_name":"salivary gland epithelial cells","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6678093671798706},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6360707879066467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5899256467819214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5497270226478577},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5375568270683289},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5284395217895508},{"id":"https://openalex.org/C2778937882","wikidata":"https://www.wikidata.org/wiki/Q134938","display_name":"Salivary gland","level":2,"score":0.5084132552146912},{"id":"https://openalex.org/C2778013207","wikidata":"https://www.wikidata.org/wiki/Q1961243","display_name":"NOD mice","level":4,"score":0.4408944845199585},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4258924722671509},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3909008502960205},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.27108943462371826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054367","descriptor_name":"Receptors, CXCR3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054370","descriptor_name":"Chemokine CXCL9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054370","descriptor_name":"Chemokine CXCL9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0077605","doi":"https://doi.org/10.1371/journal.pone.0077605","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0077605","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0077605&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2792362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3798297","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3798297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3798297","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24147035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24147035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.775.2166","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.775.2166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f5/02/pone.0077605.PMC3798297.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:47f19b5806b54f06a916b4fa0359c194","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/47f19b5806b54f06a916b4fa0359c194","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 10, p e77605 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0077605","doi":"https://doi.org/10.1371/journal.pone.0077605","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0077605","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0077605&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G160623007","display_name":"The Forsyth Core Center for Discovery at the Host-Biofilm Interface","funder_award_id":"P30DE020751","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2001501946.pdf","grobid_xml":"https://content.openalex.org/works/W2001501946.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1524794156","https://openalex.org/W1535719069","https://openalex.org/W1567420244","https://openalex.org/W1646367159","https://openalex.org/W1674389557","https://openalex.org/W1694838020","https://openalex.org/W1933188898","https://openalex.org/W1964543975","https://openalex.org/W1970895045","https://openalex.org/W1973533990","https://openalex.org/W1987047581","https://openalex.org/W1989530674","https://openalex.org/W1990808205","https://openalex.org/W1992197229","https://openalex.org/W1994094364","https://openalex.org/W2001482654","https://openalex.org/W2007608885","https://openalex.org/W2007932746","https://openalex.org/W2009253992","https://openalex.org/W2016675332","https://openalex.org/W2017922895","https://openalex.org/W2024129110","https://openalex.org/W2026780425","https://openalex.org/W2027401883","https://openalex.org/W2028575270","https://openalex.org/W2038367445","https://openalex.org/W2051208396","https://openalex.org/W2051597710","https://openalex.org/W2054979867","https://openalex.org/W2057962630","https://openalex.org/W2058158581","https://openalex.org/W2067469850","https://openalex.org/W2070878729","https://openalex.org/W2072893630","https://openalex.org/W2073253544","https://openalex.org/W2075057361","https://openalex.org/W2079350687","https://openalex.org/W2080051516","https://openalex.org/W2093683696","https://openalex.org/W2094736478","https://openalex.org/W2097301420","https://openalex.org/W2100000086","https://openalex.org/W2100262165","https://openalex.org/W2100860198","https://openalex.org/W2101694534","https://openalex.org/W2102574144","https://openalex.org/W2107339393","https://openalex.org/W2141835548","https://openalex.org/W2154692375","https://openalex.org/W2161698831","https://openalex.org/W2165205882","https://openalex.org/W2429810718","https://openalex.org/W2886065540"],"related_works":["https://openalex.org/W1524794156","https://openalex.org/W7096637013","https://openalex.org/W2792842432","https://openalex.org/W2171171811","https://openalex.org/W65650186","https://openalex.org/W1973533990","https://openalex.org/W2900664122","https://openalex.org/W3093392005","https://openalex.org/W2331588456","https://openalex.org/W6979741926"],"abstract_inverted_index":{"Elevated":[0],"IL-7":[1,21,51,84,116,136,153,198,216,234,267],"in":[2,26,35,63,86,118,138,142,161,222,236,268],"the":[3,27,65,98,113,139,156,162,184,195,237,258,269],"target":[4,270],"tissues":[5],"is":[6,263],"closely":[7],"associated":[8],"with":[9,201],"multiple":[10],"autoimmune":[11,70],"disorders,":[12],"including":[13,69],"Sj\u00f6gren's":[14],"syndrome":[15],"(SS).":[16],"We":[17,72,125],"recently":[18],"found":[19],"that":[20,48,78,127,233],"plays":[22,59],"an":[23],"essential":[24],"role":[25,62],"development":[28,185,259],"and":[29,73,88,107,121,147,189,213,219,247],"onset":[30],"of":[31,42,90,100,115,159,170,177,186,197,211,260,266],"primary":[32,43],"SS":[33],"(pSS)":[34],"C57BL/6.NOD-Aec1Aec2":[36,181],"mice,":[37],"a":[38,60,103,143,202,209,223,249],"well-defined":[39],"mouse":[40],"model":[41],"SS.":[44],"However,":[45],"environmental":[46],"signals":[47,256],"cause":[49],"excessive":[50],"production":[52,221],"are":[53],"not":[54],"well-characterized.":[55],"Innate":[56],"immune":[57,67,80,255],"signaling":[58,81,200],"critical":[61],"shaping":[64],"adaptive":[66],"responses":[68],"responses.":[71],"others":[74],"have":[75],"previously":[76],"shown":[77],"innate":[79,254],"can":[82,241],"induce":[83],"expression":[85,117,137,218,235],"lungs":[87],"intestines":[89],"C57BL/6":[91,132],"mice.":[92],"In":[93],"this":[94,190],"study,":[95],"we":[96,231],"characterized":[97],"effects":[99],"poly":[101,128,151,178,206,245],"I:C,":[102],"double-stranded":[104],"RNA":[105],"analog":[106],"toll-like":[108],"receptor":[109,199],"3":[110],"agonist,":[111],"on":[112,122],"induction":[114,265],"salivary":[119,140,163,225,238],"glands":[120,141],"pSS":[123],"development.":[124],"showed":[126],"I:C":[129,179,207,246],"administration":[130,176],"to":[131,155,180],"mice":[133,182],"rapidly":[134],"induced":[135,215,243],"type":[144],"1":[145],"IFN-":[146],"IFN-\u03b3-dependent":[148],"manner.":[149],"Moreover,":[150],"I:C-induced":[152],"contributed":[154],"optimal":[157],"up-regulation":[158],"CXCL9":[160],"glands,":[164],"which":[165,253,262],"may":[166],"subsequently":[167],"promote":[168],"recruitment":[169],"more":[171],"IFN-\u03b3-producing":[172],"T":[173],"cells.":[174],"Repeated":[175],"accelerated":[183],"SS-like":[187],"exocrinopathy,":[188],"effect":[191],"was":[192],"abolished":[193],"by":[194,244,252],"blockade":[196],"neutralizing":[203],"antibody.":[204],"Finally,":[205],"or":[208],"combination":[210],"IFN-\u03b1":[212],"IFN-\u03b3":[214],"gene":[217],"protein":[220],"human":[224],"gland":[226,239],"epithelial":[227],"cell":[228],"line.":[229],"Hence,":[230],"demonstrate":[232],"cells":[240],"be":[242],"delineate":[248],"crucial":[250],"mechanism":[251],"facilitate":[257],"pSS,":[261],"through":[264],"tissues.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
