{"id":"https://openalex.org/W2001445255","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.12.028","title":"Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats","display_name":"Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats","publication_year":2007,"publication_date":"2007-02-02","ids":{"openalex":"https://openalex.org/W2001445255","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.12.028","mag":"2001445255","pmid":"https://pubmed.ncbi.nlm.nih.gov/17349927"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2006.12.028","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.12.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2006.12.028","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012441260","display_name":"Takayuki Matsumoto","orcid":"https://orcid.org/0000-0001-9177-8384","observed_orcids":["https://orcid.org/0000-0001-9177-8384"]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Matsumoto","raw_affiliation_strings":["Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085296240","display_name":"Eri Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Noguchi","raw_affiliation_strings":["Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016159315","display_name":"Tsuneo Kobayashi","orcid":"https://orcid.org/0000-0003-2758-0730","observed_orcids":["https://orcid.org/0000-0003-2758-0730"]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo Kobayashi","raw_affiliation_strings":["Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038613022","display_name":"Katsuo Kamata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Katsuo Kamata","raw_affiliation_strings":["Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038613022"],"corresponding_institution_ids":["https://openalex.org/I36296616"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":5.5727,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.95999032,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"7","first_page":"993","last_page":"1007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":1.0},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8970000147819519},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.5820000171661377},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8980000019073486},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ap-1-signaling","display_name":"AP-1 signaling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nitric-oxide-cgmp-signaling","display_name":"nitric oxide/cGMP signaling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vasp","display_name":"VASP","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.945136308670044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6103223562240601},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5442299246788025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5295881628990173},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4805757999420166},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45724841952323914},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.41818031668663025},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3547375202178955},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2268771231174469}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2006.12.028","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.12.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2006.12.028","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:17349927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17349927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"},{"id":"mag:2783498060","doi":null,"is_oa":false,"landing_page_url":"http://polaris.hoshi.ac.jp/openresearch/10.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"},{"id":"https://openalex.org/F4320327572","display_name":"Promotion and Mutual Aid Corporation for Private Schools of Japan","ror":"https://ror.org/05h2t6865"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W103480297","https://openalex.org/W1500713135","https://openalex.org/W1974766153","https://openalex.org/W1978470067","https://openalex.org/W1981905227","https://openalex.org/W2000155150","https://openalex.org/W2005612135","https://openalex.org/W2005967137","https://openalex.org/W2007671598","https://openalex.org/W2007880055","https://openalex.org/W2009403275","https://openalex.org/W2011015201","https://openalex.org/W2012627116","https://openalex.org/W2020747080","https://openalex.org/W2025458248","https://openalex.org/W2026657209","https://openalex.org/W2029969503","https://openalex.org/W2034914370","https://openalex.org/W2034924570","https://openalex.org/W2038113052","https://openalex.org/W2039184452","https://openalex.org/W2041308641","https://openalex.org/W2042117176","https://openalex.org/W2043897455","https://openalex.org/W2048014457","https://openalex.org/W2048494288","https://openalex.org/W2052244174","https://openalex.org/W2053047827","https://openalex.org/W2055713391","https://openalex.org/W2058907768","https://openalex.org/W2060678630","https://openalex.org/W2063573267","https://openalex.org/W2064068403","https://openalex.org/W2067902287","https://openalex.org/W2068001838","https://openalex.org/W2069900564","https://openalex.org/W2074669651","https://openalex.org/W2076215026","https://openalex.org/W2076856379","https://openalex.org/W2084256679","https://openalex.org/W2087737485","https://openalex.org/W2090306106","https://openalex.org/W2094236121","https://openalex.org/W2096281503","https://openalex.org/W2098132645","https://openalex.org/W2099768574","https://openalex.org/W2100728329","https://openalex.org/W2101455391","https://openalex.org/W2103379895","https://openalex.org/W2104539000","https://openalex.org/W2112540321","https://openalex.org/W2116851073","https://openalex.org/W2117456991","https://openalex.org/W2118913197","https://openalex.org/W2121985419","https://openalex.org/W2123969526","https://openalex.org/W2125916336","https://openalex.org/W2129144866","https://openalex.org/W2131565762","https://openalex.org/W2133666147","https://openalex.org/W2141253144","https://openalex.org/W2143407149","https://openalex.org/W2148626152","https://openalex.org/W2150316108","https://openalex.org/W2151219965","https://openalex.org/W2154166124","https://openalex.org/W2158200096","https://openalex.org/W2161200308","https://openalex.org/W2162804111","https://openalex.org/W2164571514","https://openalex.org/W2166383881","https://openalex.org/W2170497762","https://openalex.org/W2171533490","https://openalex.org/W2188369434"],"related_works":["https://openalex.org/W2783498060","https://openalex.org/W2048014457","https://openalex.org/W2099768574","https://openalex.org/W2027274371","https://openalex.org/W19339161","https://openalex.org/W1983811648","https://openalex.org/W2587806732","https://openalex.org/W2334693352","https://openalex.org/W2373189470","https://openalex.org/W2059986651"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
