{"id":"https://openalex.org/W2001348596","doi":"https://doi.org/10.1002/jnr.21002","title":"Treatment with trimethyltin promotes the formation of cleaved tau in the rat brain","display_name":"Treatment with trimethyltin promotes the formation of cleaved tau in the rat brain","publication_year":2006,"publication_date":"2006-08-17","ids":{"openalex":"https://openalex.org/W2001348596","doi":"https://doi.org/10.1002/jnr.21002","mag":"2001348596","pmid":"https://pubmed.ncbi.nlm.nih.gov/16917841"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.21002","doi":"https://doi.org/10.1002/jnr.21002","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21002","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088401686","display_name":"Megan M. W. Straiko","orcid":"https://orcid.org/0000-0001-5053-7920","observed_orcids":["https://orcid.org/0000-0001-5053-7920"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.M.W. Straiko","raw_affiliation_strings":["Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio 45267, USA","Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio 45267, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112014625","display_name":"Gary A. Gudelsky","orcid":"https://orcid.org/0000-0003-2552-8592","observed_orcids":["https://orcid.org/0000-0003-2552-8592"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.A. Gudelsky","raw_affiliation_strings":["College of Pharmacy, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040630359","display_name":"Lique M. Coolen","orcid":"https://orcid.org/0000-0003-2920-1116","observed_orcids":["https://orcid.org/0000-0003-2920-1116"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.M. Coolen","raw_affiliation_strings":["Department of Anatomy, Cell Biology and Neurobiology, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Cell Biology and Neurobiology, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Harrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Harrison","raw_affiliation_strings":["Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110100846","display_name":"Frank P. Zemlan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"F.P. Zemlan","raw_affiliation_strings":["Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110100846"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.6632,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71813062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"84","issue":"5","first_page":"1116","last_page":"1123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.10329999774694443,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trimethyltin","display_name":"trimethyltin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tau-cleavage","display_name":"tau cleavage","score":0.7710000276565552},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7490000128746033},{"id":"https://openalex.org/keywords/piriform-cortex","display_name":"piriform cortex","score":1.0},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9160000085830688},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.9049999713897705},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2780382662","wikidata":"https://www.wikidata.org/wiki/Q2019583","display_name":"Piriform cortex","level":3,"score":0.9228852987289429},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.7662138342857361},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7347114086151123},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.7280248999595642},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.6574467420578003},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.61902916431427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5110422372817993},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4744642376899719},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46863365173339844},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.42423635721206665},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3698265850543976},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3320969343185425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3316989541053772},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3288964629173279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27540653944015503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24238193035125732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21240904927253723}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014298","descriptor_name":"Trimethyltin Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jnr.21002","doi":"https://doi.org/10.1002/jnr.21002","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21002","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:16917841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16917841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2881771214","display_name":null,"funder_award_id":"DA13300","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W82452007","https://openalex.org/W120605627","https://openalex.org/W1544685573","https://openalex.org/W1566743778","https://openalex.org/W1589328203","https://openalex.org/W1616748355","https://openalex.org/W1823494905","https://openalex.org/W1966781345","https://openalex.org/W1973122948","https://openalex.org/W1973207524","https://openalex.org/W1991483073","https://openalex.org/W1997087758","https://openalex.org/W2003409520","https://openalex.org/W2014888086","https://openalex.org/W2036458782","https://openalex.org/W2040898679","https://openalex.org/W2044686016","https://openalex.org/W2045951298","https://openalex.org/W2049676706","https://openalex.org/W2050753211","https://openalex.org/W2053221641","https://openalex.org/W2057714861","https://openalex.org/W2071488115","https://openalex.org/W2073090308","https://openalex.org/W2095351701","https://openalex.org/W2159159780","https://openalex.org/W2159377066","https://openalex.org/W2166933801","https://openalex.org/W2409941240","https://openalex.org/W2412200646","https://openalex.org/W2416764070","https://openalex.org/W2427538357","https://openalex.org/W4300641602"],"related_works":["https://openalex.org/W2472106296","https://openalex.org/W1963733608","https://openalex.org/W2080113480","https://openalex.org/W2054523893","https://openalex.org/W1610022545","https://openalex.org/W1589328203","https://openalex.org/W2087445430","https://openalex.org/W1217533730","https://openalex.org/W2417902638","https://openalex.org/W4300315396"],"abstract_inverted_index":{"Trimethyltin":[0],"(TMT)":[1],"is":[2,161,187],"a":[3,188],"well-documented":[4],"neurotoxin":[5],"that":[6,51,81,132,185],"affects":[7],"primarily":[8],"limbic":[9,175],"system":[10,176],"structures.":[11],"Most":[12],"previous":[13],"studies":[14,49,127],"have":[15],"relied":[16],"on":[17],"histological":[18],"approaches":[19],"to":[20,31,39,142],"examine":[21],"TMT":[22,70,88,103,160],"neurotoxicity,":[23],"so":[24],"the":[25,33,64,97,111,116,121,150,168,183],"aim":[26],"of":[27,58,66,144,152,156,170,178,191],"this":[28],"study":[29],"was":[30,89],"employ":[32],"novel":[34],"biomarker":[35],"cleaved":[36,52],"MAP-tau":[37,53],"(C-tau)":[38],"assess":[40],"TMT-induced":[41,118],"CNS":[42,192],"injury":[43],"both":[44],"quantitatively":[45],"and":[46,93,100,123,167],"qualitatively.":[47],"Immunoblot":[48],"indicated":[50],"proteins":[54],"with":[55,69,87,159],"molecular":[56],"weights":[57],"45-50":[59],"kD":[60],"were":[61,135],"present":[62],"in":[63,84,96,110,120,154,174],"hippocampus":[65,122],"rats":[67,85,157,180],"treated":[68,86,158],"but":[71],"not":[72,105],"vehicle":[73],"21":[74,94],"days":[75,95],"after":[76],"treatment.":[77],"Quantitative":[78],"ELISA":[79],"revealed":[80,131],"C-tau":[82,108,113,153,165,171,186],"concentration":[83,109,166],"greatest":[90,117],"at":[91],"14":[92],"piriform":[98,124],"cortex":[99],"hippocampus,":[101],"respectively;":[102],"did":[104],"significantly":[106],"increase":[107],"mesencephalon.":[112],"immunocytochemistry":[114,130],"demonstrated":[115],"damage":[119],"cortex.":[125],"Additional":[126],"utilizing":[128],"dual":[129],"C-tau-labeled":[133],"cells":[134,146,173],"also":[136],"glial":[137],"fibrillary":[138],"acidic":[139],"protein-positive,":[140],"leading":[141],"identification":[143],"these":[145],"as":[147],"astrocytes.":[148],"Although":[149],"origin":[151],"astrocytes":[155],"currently":[162],"unknown,":[163],"increased":[164],"presence":[169],"positive":[172],"structures":[177],"TMT-treated":[179],"further":[181],"supports":[182],"view":[184],"reliable":[189],"marker":[190],"toxicity.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}