{"id":"https://openalex.org/W2001272091","doi":"https://doi.org/10.1371/journal.pone.0023148","title":"CNTF Mediates Neurotrophic Factor Secretion and Fluid Absorption in Human Retinal Pigment Epithelium","display_name":"CNTF Mediates Neurotrophic Factor Secretion and Fluid Absorption in Human Retinal Pigment Epithelium","publication_year":2011,"publication_date":"2011-09-02","ids":{"openalex":"https://openalex.org/W2001272091","doi":"https://doi.org/10.1371/journal.pone.0023148","mag":"2001272091","pmid":"https://pubmed.ncbi.nlm.nih.gov/21912637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166283"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0023148","doi":"https://doi.org/10.1371/journal.pone.0023148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0023148","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023148&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023148&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100385047","display_name":"Rong Li","orcid":"https://orcid.org/0000-0002-4465-3324","observed_orcids":["https://orcid.org/0000-0002-4465-3324"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Li","raw_affiliation_strings":["National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686431","display_name":"Rong Wen","orcid":"https://orcid.org/0000-0001-5484-5955","observed_orcids":["https://orcid.org/0000-0001-5484-5955"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Wen","raw_affiliation_strings":["Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056267514","display_name":"Tina M. Banzon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Banzon","raw_affiliation_strings":["National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008064509","display_name":"Arvydas Maminishkis","orcid":"https://orcid.org/0000-0003-3345-3375","observed_orcids":["https://orcid.org/0000-0003-3345-3375"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvydas Maminishkis","raw_affiliation_strings":["National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022140289","display_name":"Sheldon S. Miller","orcid":"https://orcid.org/0000-0001-7495-2547","observed_orcids":["https://orcid.org/0000-0001-7495-2547"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sheldon S. Miller","raw_affiliation_strings":["National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022140289"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.4091,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.91224898,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"9","first_page":"e23148","last_page":"e23148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciliary-neurotrophic-factor","display_name":"ciliary neurotrophic factor","score":1.0},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cntf-receptor","display_name":"CNTF receptor","score":0.7360000014305115},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.7300000190734863},{"id":"https://openalex.org/keywords/jak-stat3-signaling-pathway","display_name":"JAK/STAT3 signaling","score":0.7580000162124634},{"id":"https://openalex.org/keywords/erk1-2-map-kinase","display_name":"ERK1/2 MAP kinase","score":0.8500000238418579},{"id":"https://openalex.org/keywords/apical-secretion","display_name":"apical secretion","score":0.4620000123977661},{"id":"https://openalex.org/keywords/fluid-absorption","display_name":"fluid absorption","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cftr-chloride-channel","display_name":"CFTR chloride channel","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.5649999976158142},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7820000052452087},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.875},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bruch-s-membrane","display_name":"Bruch's membrane","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C68710172","wikidata":"https://www.wikidata.org/wiki/Q14906191","display_name":"Ciliary neurotrophic factor","level":4,"score":0.9432494044303894},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7241014242172241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5434818267822266},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.4917190372943878},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4688841998577118},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4192863702774048},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.40149348974227905},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.3947039246559143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35879701375961304},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32801949977874756},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25355783104896545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15680760145187378},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14607486128807068}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001826","descriptor_name":"Body Fluids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020801","descriptor_name":"Receptor, Ciliary Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020934","descriptor_name":"Ciliary Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027702","descriptor_name":"Organic Cation Transporter 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053605","descriptor_name":"Leukemia Inhibitory Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053605","descriptor_name":"Leukemia Inhibitory Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053683","descriptor_name":"Oncostatin M","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053683","descriptor_name":"Oncostatin M","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0023148","doi":"https://doi.org/10.1371/journal.pone.0023148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0023148","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023148&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2176754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3166283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21912637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21912637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.7768","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.7768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ef/fa/PLoS_One_2011_Sep_2_6(9)_e23148.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bad8859b5eac4139879abf5f7752736a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bad8859b5eac4139879abf5f7752736a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 9, p e23148 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0023148","doi":"https://doi.org/10.1371/journal.pone.0023148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0023148","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023148&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5150968096","display_name":"CNTF and retinal degeneration: the role of Muller cells","funder_award_id":"R01EY018586","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2001272091.pdf","grobid_xml":"https://content.openalex.org/works/W2001272091.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W15311566","https://openalex.org/W107446690","https://openalex.org/W158938192","https://openalex.org/W197891902","https://openalex.org/W213150040","https://openalex.org/W310501812","https://openalex.org/W580157713","https://openalex.org/W582889863","https://openalex.org/W1437412134","https://openalex.org/W1482022071","https://openalex.org/W1489216103","https://openalex.org/W1489281785","https://openalex.org/W1489876404","https://openalex.org/W1493793044","https://openalex.org/W1499757659","https://openalex.org/W1596806582","https://openalex.org/W1597900071","https://openalex.org/W1779691448","https://openalex.org/W1780664938","https://openalex.org/W1810883461","https://openalex.org/W1820255447","https://openalex.org/W1828711994","https://openalex.org/W1963591622","https://openalex.org/W1966450087","https://openalex.org/W1973207504","https://openalex.org/W1973393536","https://openalex.org/W1974084948","https://openalex.org/W1981837304","https://openalex.org/W1981842396","https://openalex.org/W1983886405","https://openalex.org/W1985163705","https://openalex.org/W1985608223","https://openalex.org/W1986597200","https://openalex.org/W1993913137","https://openalex.org/W1997240206","https://openalex.org/W2002367555","https://openalex.org/W2005285859","https://openalex.org/W2014855145","https://openalex.org/W2016271033","https://openalex.org/W2016584341","https://openalex.org/W2020551798","https://openalex.org/W2021234912","https://openalex.org/W2024156553","https://openalex.org/W2031540625","https://openalex.org/W2032878302","https://openalex.org/W2032951723","https://openalex.org/W2034152019","https://openalex.org/W2037370744","https://openalex.org/W2041171950","https://openalex.org/W2045805322","https://openalex.org/W2052035608","https://openalex.org/W2057857889","https://openalex.org/W2058159732","https://openalex.org/W2070403771","https://openalex.org/W2073807783","https://openalex.org/W2079044795","https://openalex.org/W2082060456","https://openalex.org/W2082272798","https://openalex.org/W2086256951","https://openalex.org/W2086257051","https://openalex.org/W2086817536","https://openalex.org/W2086843235","https://openalex.org/W2087066472","https://openalex.org/W2088749707","https://openalex.org/W2094111001","https://openalex.org/W2096993232","https://openalex.org/W2099824847","https://openalex.org/W2103693357","https://openalex.org/W2105300306","https://openalex.org/W2114328086","https://openalex.org/W2121678816","https://openalex.org/W2125214813","https://openalex.org/W2125403403","https://openalex.org/W2125841107","https://openalex.org/W2136884555","https://openalex.org/W2147974112","https://openalex.org/W2153312133","https://openalex.org/W2155236757","https://openalex.org/W2164655324","https://openalex.org/W2171236632","https://openalex.org/W2171975139","https://openalex.org/W2288266213","https://openalex.org/W2325753945","https://openalex.org/W2414317503"],"related_works":["https://openalex.org/W2168681404","https://openalex.org/W1969182690","https://openalex.org/W1998225310","https://openalex.org/W2335130921","https://openalex.org/W2065074950","https://openalex.org/W2027513152","https://openalex.org/W1981842396","https://openalex.org/W2016271033","https://openalex.org/W1493793044","https://openalex.org/W3038148146"],"abstract_inverted_index":{"Ciliary":[0],"neurotrophic":[1],"factor":[2],"(CNTF)":[3],"protects":[4],"photoreceptors":[5],"and":[6,29,34,54,56,63,80,109,115,147,160,189],"regulates":[7],"their":[8,39,57],"phototransduction":[9],"machinery,":[10],"but":[11,95],"little":[12],"is":[13],"known":[14],"about":[15],"CNTF's":[16],"effects":[17],"on":[18],"retinal":[19],"pigment":[20],"epithelial":[21],"(RPE)":[22],"physiology.":[23],"Therefore,":[24],"we":[25],"determined":[26],"the":[27,35,69,84,106,135,150,161,181,184],"expression":[28],"localization":[30],"of":[31,38,44,86,98,103,112,127,157],"CNTF":[32,91,100,138],"receptors":[33],"physiological":[36],"consequence":[37],"activation":[40],"in":[41,142,152,163],"primary":[42],"cultures":[43],"human":[45],"fetal":[46],"RPE":[47,93,143],"(hfRPE).":[48],"Cultured":[49],"hfRPE":[50,128],"express":[51],"CNTF,":[52,73],"CT1,":[53,74],"OsM":[55,76,81],"receptors,":[58],"including":[59,149],"CNTFR\u03b1,":[60],"LIFR\u03b2,":[61],"gp130,":[62],"OsMR\u03b2,":[64],"all":[65],"localized":[66],"mainly":[67],"at":[68,134],"apical":[70,107],"membrane.":[71,137],"Exogenous":[72],"or":[75],"induces":[77,83,139],"STAT3":[78],"phosphorylation,":[79],"also":[82,118],"phosphorylation":[85],"ERK1/2":[87],"(p44/42":[88],"MAP":[89],"kinase).":[90],"increases":[92,101,120],"survivability,":[94],"not":[96],"rates":[97],"phagocytosis.":[99],"secretion":[102,156],"NT3":[104],"to":[105,179],"bath":[108],"decreases":[110],"that":[111],"VEGF,":[113],"IL8,":[114],"TGF\u03b22.":[116],"It":[117],"significantly":[119],"fluid":[121,165],"absorption":[122,166],"(J(V))":[123],"across":[124],"intact":[125],"monolayers":[126],"by":[129,168],"activating":[130],"CFTR":[131],"chloride":[132],"channels":[133],"basolateral":[136],"profound":[140],"changes":[141],"cell":[144,153],"biology,":[145],"biochemistry,":[146],"physiology,":[148],"increase":[151,162],"survival,":[154],"polarized":[155],"cytokines/neurotrophic":[158],"factors,":[159],"steady-state":[164],"mediated":[167],"JAK/STAT3":[169],"signaling.":[170],"In":[171],"vivo,":[172],"these":[173],"changes,":[174],"taken":[175],"together,":[176],"could":[177],"serve":[178],"regulate":[180],"microenvironment":[182],"around":[183],"distal":[185],"retinal/RPE/Bruch's":[186],"membrane":[187],"complex":[188],"provide":[190],"protection":[191],"against":[192],"neurodegenerative":[193],"disease.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}