{"id":"https://openalex.org/W2001199767","doi":"https://doi.org/10.1016/s0002-9378(12)90888-1","title":"Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues: Correlation with histopathologic features and receptors for estrogen, progesterone, and epidermal growth factor","display_name":"Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues: Correlation with histopathologic features and receptors for estrogen, progesterone, and epidermal growth factor","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2001199767","doi":"https://doi.org/10.1016/s0002-9378(12)90888-1","mag":"2001199767","pmid":"https://pubmed.ncbi.nlm.nih.gov/8420353"},"language":"en","primary_location":{"id":"doi:10.1016/s0002-9378(12)90888-1","doi":"https://doi.org/10.1016/s0002-9378(12)90888-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9378(12)90888-1","pdf_url":null,"source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026048739","display_name":"Giovanni Scambia","orcid":"https://orcid.org/0000-0002-9503-9041","observed_orcids":["https://orcid.org/0000-0002-9503-9041","https://orcid.org/0000-0003-2758-1063","https://orcid.org/0009-0009-9560-6833"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Scambia","raw_affiliation_strings":["Department of Gynecology, Catholic University, Rome, Italy","Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Catholic University, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111638873","display_name":"Laura Catozzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Catozzi","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070572496","display_name":"Pierluigi Benedetti Panici","orcid":"https://orcid.org/0000-0001-6752-2039","observed_orcids":["https://orcid.org/0000-0001-6752-2039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierluigi Benedetti Panici","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030229940","display_name":"Gabriella Ferrandina","orcid":"https://orcid.org/0000-0003-4672-4197","observed_orcids":["https://orcid.org/0000-0003-4672-4197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriella Ferrandina","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083459300","display_name":"Ferdinando Coronetta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferdinando Coronetta","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021710175","display_name":"Raffaella Barozzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaella Barozzi","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027531775","display_name":"Gabriela Crispim Baiocchi","orcid":"https://orcid.org/0000-0003-0246-5883","observed_orcids":["https://orcid.org/0000-0003-0246-5883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriela Baiocchi","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062142605","display_name":"Licia Uccelli","orcid":"https://orcid.org/0000-0002-1490-0718","observed_orcids":["https://orcid.org/0000-0002-1490-0718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Licia Uccelli","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063852457","display_name":"ADRIANO PIFFANELLI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriano Piffanelli","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005888806","display_name":"Salvatore Mancuso","orcid":"https://orcid.org/0000-0002-9874-2234","observed_orcids":["https://orcid.org/0000-0002-9874-2234"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Salvatore Mancuso","raw_affiliation_strings":["Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rome, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005888806"],"corresponding_institution_ids":[],"apc_list":{"value":5410,"currency":"USD","value_usd":5410},"apc_paid":null,"fwci":1.9164,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87243659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"168","issue":"1","first_page":"71","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8169999718666077},{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.906000018119812},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/omental-metastases","display_name":"omental metastases","score":0.8830000162124634},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.734000027179718},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6819999814033508},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.7829999923706055},{"id":"https://openalex.org/keywords/histopathological-features","display_name":"histopathological features","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.6576784253120422},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6571650505065918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6301969885826111},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6061058044433594},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.562332808971405},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5588060021400452},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.511949896812439},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.5070195198059082},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4879714846611023},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45867428183555603},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4505133032798767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44859445095062256},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4253711700439453},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.41189008951187134},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2720262408256531},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.16497015953063965},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.15707078576087952},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009852","descriptor_name":"Omentum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010048","descriptor_name":"Ovarian Cysts","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010048","descriptor_name":"Ovarian Cysts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010048","descriptor_name":"Ovarian Cysts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015689","descriptor_name":"Oncogene Protein p21(ras)","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0002-9378(12)90888-1","doi":"https://doi.org/10.1016/s0002-9378(12)90888-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9378(12)90888-1","pdf_url":null,"source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},{"id":"pmid:8420353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8420353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of obstetrics and gynecology","raw_type":"Journal Article"},{"id":"pmh:oai:sfera.unife.it:11392/1777105","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/1777105","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W17178929","https://openalex.org/W1493551679","https://openalex.org/W1783764936","https://openalex.org/W1900738452","https://openalex.org/W1979300931","https://openalex.org/W1988925715","https://openalex.org/W1996729627","https://openalex.org/W2016970611","https://openalex.org/W2019198702","https://openalex.org/W2020283335","https://openalex.org/W2022206818","https://openalex.org/W2039916012","https://openalex.org/W2046513857","https://openalex.org/W2057159445","https://openalex.org/W2061636074","https://openalex.org/W2064446750","https://openalex.org/W2065951262","https://openalex.org/W2074951828","https://openalex.org/W2075102280","https://openalex.org/W2075612889","https://openalex.org/W2091723114","https://openalex.org/W2113210366","https://openalex.org/W2123538809","https://openalex.org/W2128635872","https://openalex.org/W2146447599","https://openalex.org/W2147869809","https://openalex.org/W2180795626","https://openalex.org/W2400940104","https://openalex.org/W2409103608","https://openalex.org/W2440641407","https://openalex.org/W3041047318","https://openalex.org/W6629453400"],"related_works":["https://openalex.org/W7009752129","https://openalex.org/W1966186964","https://openalex.org/W2092702915","https://openalex.org/W1968750874","https://openalex.org/W7096044158","https://openalex.org/W2350116032","https://openalex.org/W2048923236","https://openalex.org/W2439343438","https://openalex.org/W2414563053","https://openalex.org/W2377198893"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}