{"id":"https://openalex.org/W2001175596","doi":"https://doi.org/10.1002/bms.1200110607","title":"The decomposition of benzodiazepines during analysis by capillary gas chromatography/mass spectrometry","display_name":"The decomposition of benzodiazepines during analysis by capillary gas chromatography/mass spectrometry","publication_year":1984,"publication_date":"1984-06-01","ids":{"openalex":"https://openalex.org/W2001175596","doi":"https://doi.org/10.1002/bms.1200110607","mag":"2001175596","pmid":"https://pubmed.ncbi.nlm.nih.gov/6743768"},"language":"en","primary_location":{"id":"doi:10.1002/bms.1200110607","doi":"https://doi.org/10.1002/bms.1200110607","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bms.1200110607","pdf_url":null,"source":{"id":"https://openalex.org/S37349105","display_name":"Journal of Mass Spectrometry","issn_l":"1076-5174","issn":["1076-5174","1096-9888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032578042","display_name":"J.R. Joyce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283026217","display_name":"Home Office","ror":"https://ror.org/00y81cg83","country_code":"GB","type":"government","lineage":["https://openalex.org/I1283026217","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. R. Joyce","raw_affiliation_strings":["Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK","institution_ids":["https://openalex.org/I1283026217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080671349","display_name":"Tara Singh Bal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283026217","display_name":"Home Office","ror":"https://ror.org/00y81cg83","country_code":"GB","type":"government","lineage":["https://openalex.org/I1283026217","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. S. Bal","raw_affiliation_strings":["Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK","institution_ids":["https://openalex.org/I1283026217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061418686","display_name":"ROBERT E. ARDREY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283026217","display_name":"Home Office","ror":"https://ror.org/00y81cg83","country_code":"GB","type":"government","lineage":["https://openalex.org/I1283026217","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. E. Ardrey","raw_affiliation_strings":["Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK","institution_ids":["https://openalex.org/I1283026217"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. M. Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283026217","display_name":"Home Office","ror":"https://ror.org/00y81cg83","country_code":"GB","type":"government","lineage":["https://openalex.org/I1283026217","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. M. Stevens","raw_affiliation_strings":["Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK","institution_ids":["https://openalex.org/I1283026217"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113179722","display_name":"A.C. Moffat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283026217","display_name":"Home Office","ror":"https://ror.org/00y81cg83","country_code":"GB","type":"government","lineage":["https://openalex.org/I1283026217","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. C. Moffat","raw_affiliation_strings":["Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berkshire, RG7 4PN, UK","institution_ids":["https://openalex.org/I1283026217"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1283026217"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":2.6655,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.87709497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"6","first_page":"284","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thermal-decomposition","display_name":"thermal decomposition","score":0.9110000133514404},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.7770000100135803},{"id":"https://openalex.org/keywords/capillary-gas-chromatography-mass-spectrometry","display_name":"capillary gas chromatography-mass spectrometry","score":0.8360000252723694},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chlordiazepoxide","display_name":"chlordiazepoxide","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nitrazepam","display_name":"nitrazepam","score":0.9559999704360962},{"id":"https://openalex.org/keywords/clonazepam","display_name":"clonazepam","score":1.0},{"id":"https://openalex.org/keywords/lormetazepam","display_name":"lormetazepam","score":0.921999990940094},{"id":"https://openalex.org/keywords/temazepam","display_name":"temazepam","score":1.0},{"id":"https://openalex.org/keywords/oxazepam","display_name":"oxazepam","score":0.6729999780654907},{"id":"https://openalex.org/keywords/lorazepam","display_name":"lorazepam","score":0.9480000138282776},{"id":"https://openalex.org/keywords/alpha-hydroxy-ketones","display_name":"\u03b1-hydroxy ketones","score":0.7760000228881836},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.6259999871253967},{"id":"https://openalex.org/keywords/drug-quantification","display_name":"pharmaceutical analysis","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2777207853","wikidata":"https://www.wikidata.org/wiki/Q410078","display_name":"Nitrazepam","level":3,"score":0.9146683812141418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8234482407569885},{"id":"https://openalex.org/C2781006864","wikidata":"https://www.wikidata.org/wiki/Q414796","display_name":"Temazepam","level":4,"score":0.7619030475616455},{"id":"https://openalex.org/C2776615572","wikidata":"https://www.wikidata.org/wiki/Q412299","display_name":"Oxazepam","level":4,"score":0.7366937398910522},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6772109270095825},{"id":"https://openalex.org/C2779426884","wikidata":"https://www.wikidata.org/wiki/Q407988","display_name":"Clonazepam","level":2,"score":0.5787041783332825},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.539138674736023},{"id":"https://openalex.org/C2778519950","wikidata":"https://www.wikidata.org/wiki/Q422435","display_name":"Bromazepam","level":4,"score":0.5235709547996521},{"id":"https://openalex.org/C2779738154","wikidata":"https://www.wikidata.org/wiki/Q412143","display_name":"Triazolam","level":4,"score":0.5125829577445984},{"id":"https://openalex.org/C40325409","wikidata":"https://www.wikidata.org/wiki/Q2360668","display_name":"Mass spectrum","level":3,"score":0.4457378089427948},{"id":"https://openalex.org/C2778325228","wikidata":"https://www.wikidata.org/wiki/Q178566","display_name":"Chlordiazepoxide","level":3,"score":0.4182223081588745},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.37108010053634644},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.3542899489402771},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.07441669702529907},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bms.1200110607","doi":"https://doi.org/10.1002/bms.1200110607","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bms.1200110607","pdf_url":null,"source":{"id":"https://openalex.org/S37349105","display_name":"Journal of Mass Spectrometry","issn_l":"1076-5174","issn":["1076-5174","1096-9888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:6743768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6743768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical mass spectrometry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1524527800","https://openalex.org/W1968246827","https://openalex.org/W1978092825","https://openalex.org/W1988576601","https://openalex.org/W2001670776","https://openalex.org/W2029676441","https://openalex.org/W2041261404","https://openalex.org/W2050063664","https://openalex.org/W2055141639","https://openalex.org/W2059878385"],"related_works":["https://openalex.org/W2021370240","https://openalex.org/W2400288089","https://openalex.org/W2003524122","https://openalex.org/W1995056067","https://openalex.org/W1970912081","https://openalex.org/W2053154344","https://openalex.org/W2917693810","https://openalex.org/W2042209279","https://openalex.org/W2390719486","https://openalex.org/W2002233989"],"abstract_inverted_index":{"A":[0],"capillary":[1],"gas":[2,51],"chromatography":[3],"column":[4],"directly":[5],"interfaced":[6],"to":[7,27,30,66,88,120,144,150],"a":[8,117],"mass":[9,136],"spectrometer":[10],"was":[11,25],"used":[12],"for":[13,165],"the":[14,23,36,48,89,100,114,122,132,138,169],"analysis":[15],"of":[16,22,35,50,57,102,116,161],"sixteen":[17],"benzodiazepines.":[18],"The":[19,59],"thermal":[20],"stability":[21],"drugs":[24,133],"found":[26],"be":[28,45],"related":[29],"their":[31,135],"chemical":[32],"structure.":[33],"Nine":[34],"benzodiazepines":[37,61],"were":[38,128,156,171,180],"thermally":[39],"unstable":[40,60],"indicating":[41],"that":[42],"care":[43],"should":[44],"taken":[46],"in":[47,130],"interpretation":[49],"chromatographic":[52],"data":[53],"from":[54,158],"this":[55],"class":[56],"drugs.":[58],"were:":[62],"ketazolam":[63,141],"which":[64,73,84,97,110,142,148],"decomposes":[65,143,149],"diazepam;":[67],"N-4":[68],"oxides":[69],"(chlordiazepoxide":[70],"and":[71,82,95,104,108,146],"demoxepam)":[72],"lose":[74],"an":[75],"oxygen":[76],"radical;":[77],"aromatic":[78],"7-nitro":[79],"compounds":[80,167],"(nitrazepam":[81],"clonazepam)":[83],"are":[85],"partially":[86,111],"reduced":[87],"corresponding":[90,123],"amine;":[91],"alpha-hydroxy":[92],"ketones":[93,106],"(lorazepam":[94],"oxazepam)":[96],"decompose":[98,112],"with":[99,113],"loss":[101,115],"water":[103],"N-methyl-alpha-hydroxy":[105],"(lormetazepam":[107],"temazepam)":[109,177],"hydrogen":[118],"molecule":[119],"produce":[121],"alpha,":[124],"beta-diketones.":[125],"Few":[126],"problems":[127],"encountered":[129],"distinguishing":[131],"by":[134],"spectra,":[137],"exceptions":[139],"being":[140],"diazepam":[145],"demoxepam":[147],"desmethyldiazepam.":[151],"In":[152],"general,":[153],"good":[154],"spectra":[155],"obtained":[157],"20-50":[159],"ng":[160],"drug":[162],"injected.":[163],"However,":[164],"those":[166],"where":[168],"decompositions":[170],"not":[172],"quantitative":[173],"(nitrazepam,":[174],"clonazepam,":[175],"lormetazepam,":[176],"detection":[178],"limits":[179],"poor.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
