{"id":"https://openalex.org/W2001107654","doi":"https://doi.org/10.1371/journal.pgen.1004447","title":"N-WASP Is Required for Structural Integrity of the Blood-Testis Barrier","display_name":"N-WASP Is Required for Structural Integrity of the Blood-Testis Barrier","publication_year":2014,"publication_date":"2014-06-26","ids":{"openalex":"https://openalex.org/W2001107654","doi":"https://doi.org/10.1371/journal.pgen.1004447","mag":"2001107654","pmid":"https://pubmed.ncbi.nlm.nih.gov/24967734","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4072540"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1004447","doi":"https://doi.org/10.1371/journal.pgen.1004447","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1004447","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004447&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004447&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101850475","display_name":"Xiang Xiao","orcid":"https://orcid.org/0000-0002-0030-9724","observed_orcids":["https://orcid.org/0000-0002-0030-9724"]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang Xiao","raw_affiliation_strings":["The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041273456","display_name":"Dolores D. Mruk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolores D. Mruk","raw_affiliation_strings":["The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010327016","display_name":"Elizabeth I. Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth I. Tang","raw_affiliation_strings":["The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013190616","display_name":"Rada Massarwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R'ada Massarwa","raw_affiliation_strings":["Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel#TAB#","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109864731","display_name":"Ka\u2010Wai Mok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ka Wai Mok","raw_affiliation_strings":["The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341013","display_name":"Nan Li","orcid":"https://orcid.org/0000-0001-7808-5161","observed_orcids":["https://orcid.org/0000-0001-7808-5161"]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Li","raw_affiliation_strings":["The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078680760","display_name":"Chris K.C. Wong","orcid":"https://orcid.org/0000-0001-5449-5836","observed_orcids":["https://orcid.org/0000-0001-5449-5836"]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Chris K. C. Wong","raw_affiliation_strings":["Department of Biology, Hong Kong Baptist University, Hong Kong, China","Department of Biology, Hong Kong Baptist Univ., Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Hong Kong Baptist University, Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]},{"raw_affiliation_string":"Department of Biology, Hong Kong Baptist Univ., Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048483050","display_name":"Will M. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Will M. Lee","raw_affiliation_strings":["School of Biological Sciences, University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052060864","display_name":"Scott B. Snapper","orcid":"https://orcid.org/0000-0003-0267-4247","observed_orcids":["https://orcid.org/0000-0003-0267-4247"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott B. Snapper","raw_affiliation_strings":["Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032460765","display_name":"Ben\u2010Zion Shilo","orcid":"https://orcid.org/0000-0003-4903-8889","observed_orcids":["https://orcid.org/0000-0003-4903-8889"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ben-Zion Shilo","raw_affiliation_strings":["Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel#TAB#","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021778634","display_name":"Eyal D. Schejter","orcid":"https://orcid.org/0000-0001-6093-5973","observed_orcids":["https://orcid.org/0000-0001-6093-5973"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Eyal D. Schejter","raw_affiliation_strings":["Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel#TAB#","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072413923","display_name":"C. Yan Cheng","orcid":"https://orcid.org/0000-0003-3117-3791","observed_orcids":["https://orcid.org/0000-0003-3117-3791"]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Yan Cheng","raw_affiliation_strings":["The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, United States of America","institution_ids":["https://openalex.org/I4210132262"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021778634","https://openalex.org/A5072413923"],"corresponding_institution_ids":["https://openalex.org/I4210132262","https://openalex.org/I53964585"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":6.0531,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.95609938,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"6","first_page":"e1004447","last_page":"e1004447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-wasp","display_name":"N-WASP","score":0.8970000147819519},{"id":"https://openalex.org/keywords/blood-testis-barrier","display_name":"blood-testis barrier","score":0.996999979019165},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/arp2-3-complex","display_name":"Arp2/3 complex","score":0.925000011920929},{"id":"https://openalex.org/keywords/branched-actin","display_name":"branched actin","score":0.7749999761581421},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.7870000004768372},{"id":"https://openalex.org/keywords/endocytic-recycling","display_name":"endocytic recycling","score":0.921999990940094},{"id":"https://openalex.org/keywords/seminiferous-epithelium","display_name":"seminiferous epithelium","score":0.8679999709129333},{"id":"https://openalex.org/keywords/junctional-proteins","display_name":"junctional proteins","score":0.6010000109672546},{"id":"https://openalex.org/keywords/germ-cell-maturation","display_name":"germ cell maturation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/barrier-integrity","display_name":"barrier integrity","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C2636012","wikidata":"https://www.wikidata.org/wiki/Q489842","display_name":"Blood\u2013testis barrier","level":4,"score":0.8279822468757629},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8014494180679321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8005281686782837},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.6909687519073486},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.6279204487800598},{"id":"https://openalex.org/C2778054371","wikidata":"https://www.wikidata.org/wiki/Q503431","display_name":"Seminiferous tubule","level":4,"score":0.6142301559448242},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5003137588500977},{"id":"https://openalex.org/C2777394357","wikidata":"https://www.wikidata.org/wiki/Q1494188","display_name":"Spermatid","level":3,"score":0.4932982325553894},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.4693164825439453},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4527481198310852},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4258680045604706},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4170927107334137},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.41301673650741577},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17041224241256714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16787511110305786},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11497613787651062},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06121128797531128}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001814","descriptor_name":"Blood-Testis Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012670","descriptor_name":"Seminiferous Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013087","descriptor_name":"Spermatids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013090","descriptor_name":"Spermatocytes","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013090","descriptor_name":"Spermatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051317","descriptor_name":"Wiskott-Aldrich Syndrome Protein, Neuronal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051376","descriptor_name":"Actin-Related Protein 2-3 Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051376","descriptor_name":"Actin-Related Protein 2-3 Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pgen.1004447","doi":"https://doi.org/10.1371/journal.pgen.1004447","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1004447","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004447&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4072540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4072540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:24967734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24967734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/12717588","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717588","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:repository.hkbu.edu.hk:hkbu_staff_publication-2384","doi":null,"is_oa":false,"landing_page_url":"https://repository.hkbu.edu.hk/hkbu_staff_publication/1370","pdf_url":null,"source":{"id":"https://openalex.org/S4377196872","display_name":"HKBU Institutional Repository (Hong Kong Baptist University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141568987","host_organization_name":"Hong Kong Baptist University","host_organization_lineage":["https://openalex.org/I141568987"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HKBU Staff Publication","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8b94d083f01a4d2a997accb398665ee3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8b94d083f01a4d2a997accb398665ee3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 10, Iss 6, p e1004447 (2014)","raw_type":"article"},{"id":"pmh:oai:hub.hku.hk:10722/201554","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10722/201554","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1004447","doi":"https://doi.org/10.1371/journal.pgen.1004447","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1004447","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004447&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2880103442","display_name":"Biology of the Blood-Testis Barrier","funder_award_id":"R01HD056034","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7913906242","display_name":"Cooperative Contraceptive Research Center: New Contraceptives with Dual Benefits","funder_award_id":"U54HD029990","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000101805","display_name":null,"funder_award_id":"HD029990","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320955","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2001107654.pdf","grobid_xml":"https://content.openalex.org/works/W2001107654.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1430767936","https://openalex.org/W1498435062","https://openalex.org/W1531063601","https://openalex.org/W1531691852","https://openalex.org/W1542467604","https://openalex.org/W1547644997","https://openalex.org/W1549271450","https://openalex.org/W1600430222","https://openalex.org/W1844503037","https://openalex.org/W1964157134","https://openalex.org/W1966221925","https://openalex.org/W1968283566","https://openalex.org/W1968907717","https://openalex.org/W1997228602","https://openalex.org/W1997950878","https://openalex.org/W2003695272","https://openalex.org/W2005537768","https://openalex.org/W2006509394","https://openalex.org/W2011560862","https://openalex.org/W2014843698","https://openalex.org/W2023403043","https://openalex.org/W2026428103","https://openalex.org/W2030958131","https://openalex.org/W2036976320","https://openalex.org/W2045457002","https://openalex.org/W2045527675","https://openalex.org/W2067078346","https://openalex.org/W2068367840","https://openalex.org/W2076676430","https://openalex.org/W2085487017","https://openalex.org/W2091901955","https://openalex.org/W2092588243","https://openalex.org/W2094258184","https://openalex.org/W2098737213","https://openalex.org/W2106267004","https://openalex.org/W2107219745","https://openalex.org/W2107564206","https://openalex.org/W2109826292","https://openalex.org/W2123027473","https://openalex.org/W2130255848","https://openalex.org/W2130442033","https://openalex.org/W2131812111","https://openalex.org/W2132471784","https://openalex.org/W2132606004","https://openalex.org/W2134957357","https://openalex.org/W2143463671","https://openalex.org/W2144161917","https://openalex.org/W2162413723","https://openalex.org/W2164490852","https://openalex.org/W2169186082","https://openalex.org/W2199166086"],"related_works":["https://openalex.org/W2005537768","https://openalex.org/W1503049147","https://openalex.org/W2162553879","https://openalex.org/W2253219637","https://openalex.org/W3192499656","https://openalex.org/W2794322445","https://openalex.org/W2794073289","https://openalex.org/W2030796861","https://openalex.org/W4405741592","https://openalex.org/W2011560862"],"abstract_inverted_index":{"During":[0],"spermatogenesis,":[1,177],"the":[2,7,14,33,41,48,51,56,65,71,84,110,131,152,179,183,187],"blood-testis":[3],"barrier":[4,78,167],"(BTB)":[5],"segregates":[6],"adluminal":[8,21],"(apical)":[9],"and":[10,102,159,162],"basal":[11],"compartments":[12],"in":[13,143,147,172,190],"seminiferous":[15,57,72,188],"epithelium,":[16],"thereby":[17],"creating":[18],"a":[19,173],"privileged":[20],"environment":[22],"that":[23,83,109],"allows":[24],"post-meiotic":[25],"spermatid":[26],"development":[27],"to":[28,63,129,151,164],"proceed":[29],"without":[30],"interference":[31],"of":[32,40,55,67,122,137,141,156,166,176,182,186],"host":[34],"immune":[35],"system.":[36],"A":[37],"key":[38],"feature":[39],"BTB":[42,100,123,138],"is":[43,61],"its":[44],"continuous":[45],"remodeling":[46,60],"within":[47],"Sertoli":[49,144],"cells,":[50],"major":[52,148],"somatic":[53,184],"component":[54],"epithelium.":[58],"This":[59],"necessary":[62,98],"allow":[64],"transport":[66],"germ":[68,191],"cells":[69,145],"towards":[70],"tubule":[73],"interior,":[74],"while":[75],"maintaining":[76,104],"intact":[77],"properties.":[79],"Here":[80],"we":[81],"demonstrate":[82],"actin":[85,112],"nucleation":[86],"promoting":[87],"factor":[88],"Neuronal":[89],"Wiskott-Aldrich":[90],"Syndrome":[91],"Protein":[92],"(N-WASP)":[93],"provides":[94],"an":[95,119],"essential":[96],"function":[97],"for":[99,103],"restructuring,":[101],"spermatogenesis.":[105],"Our":[106],"data":[107],"suggests":[108],"N-WASP-Arp2/3":[111],"polymerization":[113],"machinery":[114],"generates":[115],"branched-actin":[116],"arrays":[117,126],"at":[118],"advanced":[120],"stage":[121],"remodeling.":[124],"These":[125,169],"are":[127],"proposed":[128],"mediate":[130],"restructuring":[132],"process":[133],"through":[134],"endocytic":[135],"recycling":[136],"components.":[139],"Disruption":[140],"N-WASP":[142],"results":[146],"structural":[149],"abnormalities":[150],"BTB,":[153],"including":[154],"mis-localization":[155],"critical":[157,180],"junctional":[158],"cytoskeletal":[160],"elements,":[161],"leads":[163],"disruption":[165],"function.":[168],"impairments":[170],"result":[171],"complete":[174],"arrest":[175],"underscoring":[178],"involvement":[181],"compartment":[185],"tubules":[189],"cell":[192],"maturation.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}