{"id":"https://openalex.org/W2001079133","doi":"https://doi.org/10.1111/j.1365-2753.2003.00484.x","title":"An evaluation of risk factors for adverse drug events associated with angiotensin\u2010converting enzyme inhibitors","display_name":"An evaluation of risk factors for adverse drug events associated with angiotensin\u2010converting enzyme inhibitors","publication_year":2004,"publication_date":"2004-10-08","ids":{"openalex":"https://openalex.org/W2001079133","doi":"https://doi.org/10.1111/j.1365-2753.2003.00484.x","mag":"2001079133","pmid":"https://pubmed.ncbi.nlm.nih.gov/15482412"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2753.2003.00484.x","doi":"https://doi.org/10.1111/j.1365-2753.2003.00484.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2753.2003.00484.x","pdf_url":null,"source":{"id":"https://openalex.org/S2713501","display_name":"Journal of Evaluation in Clinical Practice","issn_l":"1356-1294","issn":["1356-1294","1365-2753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Evaluation in Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080185082","display_name":"Takeshi Morimoto","orcid":"https://orcid.org/0000-0002-6844-739X","observed_orcids":["https://orcid.org/0000-0002-6844-739X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takeshi Morimoto","raw_affiliation_strings":["Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA 02115, USA","Department of Clinical Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan","Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","Harvard School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Clinical Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103687886","display_name":"Tejal K. Gandhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tejal K. Gandhi","raw_affiliation_strings":["Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111444022","display_name":"Julie M. Fiskio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie M. Fiskio","raw_affiliation_strings":["Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044752050","display_name":"Andrew C. Seger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew C. Seger","raw_affiliation_strings":["Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023904183","display_name":"Joseph W. So","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph W. So","raw_affiliation_strings":["Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111516482","display_name":"Earl Francis Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Francis Cook","raw_affiliation_strings":["Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","Harvard School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100973543","display_name":"Tsuguya Fukui","orcid":"https://orcid.org/0009-0009-2835-8892","observed_orcids":["https://orcid.org/0009-0009-2835-8892"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuguya Fukui","raw_affiliation_strings":["Department of Clinical Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036110536","display_name":"David Westfall Bates","orcid":"https://orcid.org/0000-0001-6268-1540","observed_orcids":["https://orcid.org/0000-0001-6268-1540","https://orcid.org/0000-0003-4850-2360","https://orcid.org/0000-0001-7438-9491","https://orcid.org/0000-0002-3105-156X","https://orcid.org/0000-0001-5440-6039"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David W. Bates","raw_affiliation_strings":["Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","Harvard School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036110536"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":6.1866,"has_fulltext":false,"cited_by_count":211,"citation_normalized_percentile":{"value":0.96804129,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"10","issue":"4","first_page":"499","last_page":"509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.23109999299049377,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9980000257492065},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ace-inhibitor-induced-cough","display_name":"ACE inhibitor-induced cough","score":0.8700000047683716},{"id":"https://openalex.org/keywords/angioedema","display_name":"angioedema","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hyperkalemia","display_name":"hyperkalemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8460000157356262},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6019999980926514},{"id":"https://openalex.org/keywords/ethnicity","display_name":"ethnicity","score":0.6489999890327454},{"id":"https://openalex.org/keywords/east-asians","display_name":"East Asians","score":0.5299999713897705},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8289999961853027},{"id":"https://openalex.org/keywords/anxiety-and-depression","display_name":"anxiety and depression","score":0.7160000205039978},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.48100000619888306},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.625},{"id":"https://openalex.org/keywords/out-of-hours-care","display_name":"out-of-hours care","score":0.39399999380111694},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8693172931671143},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.7432647943496704},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7078287601470947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6838486790657043},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6732407808303833},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.5197027325630188},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5088496208190918},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.46131324768066406},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.45377451181411743},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.445633202791214},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4250313639640808},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.264806866645813},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10952645540237427}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001900","descriptor_name":"Boston","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006786","descriptor_name":"Hospitals, Urban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010044","descriptor_name":"Outpatient Clinics, Hospital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2753.2003.00484.x","doi":"https://doi.org/10.1111/j.1365-2753.2003.00484.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2753.2003.00484.x","pdf_url":null,"source":{"id":"https://openalex.org/S2713501","display_name":"Journal of Evaluation in Clinical Practice","issn_l":"1356-1294","issn":["1356-1294","1365-2753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Evaluation in Clinical Practice","raw_type":"journal-article"},{"id":"pmid:15482412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15482412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of evaluation in clinical practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G365823881","display_name":null,"funder_award_id":"R01-HS11169","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"}],"funders":[{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W30674866","https://openalex.org/W34638141","https://openalex.org/W47246477","https://openalex.org/W110669118","https://openalex.org/W1585698055","https://openalex.org/W1798263776","https://openalex.org/W1974345717","https://openalex.org/W1987792737","https://openalex.org/W1991106789","https://openalex.org/W1998988712","https://openalex.org/W1999733114","https://openalex.org/W2000451387","https://openalex.org/W2004728723","https://openalex.org/W2011740327","https://openalex.org/W2016648729","https://openalex.org/W2022909531","https://openalex.org/W2025970694","https://openalex.org/W2027870509","https://openalex.org/W2039665384","https://openalex.org/W2043738117","https://openalex.org/W2051188283","https://openalex.org/W2073071189","https://openalex.org/W2095818009","https://openalex.org/W2111856132","https://openalex.org/W2121055261","https://openalex.org/W2126721368","https://openalex.org/W2133354801","https://openalex.org/W2153308521","https://openalex.org/W2160191533","https://openalex.org/W2163974575","https://openalex.org/W2170586037","https://openalex.org/W2212321898","https://openalex.org/W4235340527"],"related_works":["https://openalex.org/W4378349621","https://openalex.org/W1965896168","https://openalex.org/W3101711544","https://openalex.org/W2133354801","https://openalex.org/W2312186855","https://openalex.org/W1586529295","https://openalex.org/W2409643391","https://openalex.org/W2064177694","https://openalex.org/W3213167312","https://openalex.org/W7165821949"],"abstract_inverted_index":{"RATIONALE,":[0],"AIMS":[1],"AND":[2],"OBJECTIVES:":[3],"To":[4],"identify":[5,247],"potential":[6],"factors":[7,70,243],"leading":[8],"to":[9,41,117,184,209,227],"discontinuation":[10,72],"of":[11,17,48,57,74,90,96,113,147,189,257],"angiotensin-converting":[12],"enzyme":[13],"(ACE)":[14],"inhibitors":[15,38,53,187],"because":[16,56,73,188,256],"adverse":[18,58,75,253],"drug":[19,59,76,254],"events.":[20,60],"METHODS:":[21],"Retrospective":[22],"cohort":[23],"study":[24],"was":[25,115,151],"conducted":[26],"at":[27],"outpatient":[28],"clinics":[29],"affiliated":[30],"with":[31,174,249],"an":[32],"urban":[33],"tertiary":[34],"care":[35],"hospital.":[36],"ACE":[37,52,92,101,148,186,258],"were":[39,54,182,206],"administered":[40],"2225":[42],"consecutive":[43],"outpatients.":[44],"RESULTS:":[45],"In":[46],"19%":[47],"the":[49,66],"total":[50],"cohort,":[51],"discontinued":[55],"Cox":[61],"proportional":[62],"hazard":[63],"model":[64],"identified":[65],"following":[67],"independent":[68],"risk":[69,120,155,242,251],"for":[71,122,157,166,252],"events:":[77],"age,":[78],"female":[79],"gender,":[80],"ethnicity":[81],"other":[82],"than":[83],"African":[84,225],"American":[85],"or":[86,105,177],"Latino,":[87],"no":[88,107],"history":[89,95],"previous":[91],"inhibitor":[93],"use,":[94],"cough":[97,123,150,158,211],"caused":[98],"by":[99],"another":[100],"inhibitor,":[102],"hypertension,":[103],"anxiety":[104],"depression,":[106],"hemodialysis,":[108],"and":[109,139,197,217,224],"elevated":[110,250],"creatinine.":[111],"History":[112,146],"smoking":[114],"shown":[116],"be":[118],"a":[119,154],"factor":[121,156],"[hazard":[124],"ratio":[125],"(HR):":[126],"2.5;":[127,213],"95%":[128,136,143,161,170,194,201,214,221,232],"confidence":[129],"interval":[130],"(CI):":[131],"1.1-5.7],":[132],"angioedema":[133,167,229],"(HR:":[134,141,159,168,192,199,212,219,230],"2.7;":[135],"CI:":[137,144,162,171,195,202,215,222,233],"1.1-7.0),":[138],"hyperkalaemia":[140,198,218],"5.4;":[142],"1.3-23.2).":[145],"inhibitor-induced":[149],"not":[152],"only":[153],"12.9;":[160],"7.5-22.3)":[163],"but":[164],"also":[165],"9.1;":[169],"2.1-39.9).":[172],"Patients":[173],"creatinine":[175],">":[176],"=":[178],"1.6":[179],"mg":[180],"dL(-1)":[181],"likely":[183,208],"discontinue":[185],"renal":[190],"dysfunction":[191],"4.7;":[193],"1.5-12.7)":[196],"10.9;":[200],"3.1-39.0).":[203],"East":[204],"Asians":[205],"more":[207],"develop":[210,228],"1.1-5.7)":[216],"80.3;":[220],"5.4-1190)":[223],"Americans":[226],"3.5;":[231],"1.3-8.9).":[234],"CONCLUSIONS:":[235],"Although":[236],"further":[237],"validation":[238],"is":[239],"necessary,":[240],"these":[241],"should":[244],"help":[245],"doctors":[246],"patients":[248],"events":[255],"inhibitors.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
