{"id":"https://openalex.org/W2001040458","doi":"https://doi.org/10.1016/0003-2697(84)90001-0","title":"Purification of pepsins and cathepsin D by affinity chromatography on Sepharose 4B with an immobilized synthetic inhibitor","display_name":"Purification of pepsins and cathepsin D by affinity chromatography on Sepharose 4B with an immobilized synthetic inhibitor","publication_year":1984,"publication_date":"1984-06-01","ids":{"openalex":"https://openalex.org/W2001040458","doi":"https://doi.org/10.1016/0003-2697(84)90001-0","mag":"2001040458","pmid":"https://pubmed.ncbi.nlm.nih.gov/6433740"},"language":"en","primary_location":{"id":"doi:10.1016/0003-2697(84)90001-0","doi":"https://doi.org/10.1016/0003-2697(84)90001-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-2697(84)90001-0","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112688903","display_name":"Jan Pohl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Jan Pohl","raw_affiliation_strings":["Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Science, Flemingovo 2, Prague 6, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Science, Flemingovo 2, Prague 6, Czechoslovakia","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051524903","display_name":"M. Zaoral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Milan Zaoral","raw_affiliation_strings":["Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Science, Flemingovo 2, Prague 6, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Science, Flemingovo 2, Prague 6, Czechoslovakia","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110200345","display_name":"Anton\u00edn Jindra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Anton\u00edn Jindra","raw_affiliation_strings":["2nd Department of Internal Medicine, Charles University, Prague 2, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine, Charles University, Prague 2, Czechoslovakia","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113765953","display_name":"V. Kostka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Vladim\u00edr Kostka","raw_affiliation_strings":["Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Science, Flemingovo 2, Prague 6, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Science, Flemingovo 2, Prague 6, Czechoslovakia","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112688903"],"corresponding_institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.8537,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.66701637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"139","issue":"2","first_page":"265","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.1868000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pepsin","display_name":"pepsin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.996999979019165},{"id":"https://openalex.org/keywords/gastricsin","display_name":"gastricsin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/affinity-chromatography","display_name":"affinity chromatography","score":0.8159999847412109},{"id":"https://openalex.org/keywords/sepharose-4b","display_name":"Sepharose 4B","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pepstatin","display_name":"pepstatin","score":0.7929999828338623},{"id":"https://openalex.org/keywords/aspartic-protease","display_name":"aspartic protease","score":0.8539999723434448},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cysteine-endopeptidase","display_name":"cysteine endopeptidase","score":0.7960000038146973},{"id":"https://openalex.org/keywords/plasma-renin","display_name":"plasma renin","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.7939918041229248},{"id":"https://openalex.org/C2779881004","wikidata":"https://www.wikidata.org/wiki/Q7451876","display_name":"Sepharose","level":3,"score":0.7627257108688354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6777223348617554},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6772164106369019},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.5127514600753784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43250900506973267},{"id":"https://openalex.org/C3018687534","wikidata":"https://www.wikidata.org/wiki/Q7251225","display_name":"Proteinase inhibitor","level":3,"score":0.4224622845649719},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3258854150772095}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012685","descriptor_name":"Sepharose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0003-2697(84)90001-0","doi":"https://doi.org/10.1016/0003-2697(84)90001-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-2697(84)90001-0","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},{"id":"pmid:6433740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6433740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W76049288","https://openalex.org/W109988810","https://openalex.org/W1484115349","https://openalex.org/W1485756237","https://openalex.org/W1486529618","https://openalex.org/W1909735082","https://openalex.org/W1973750333","https://openalex.org/W1976730059","https://openalex.org/W1984165183","https://openalex.org/W1990688767","https://openalex.org/W1991489244","https://openalex.org/W1993561299","https://openalex.org/W2002939578","https://openalex.org/W2013524125","https://openalex.org/W2032178297","https://openalex.org/W2042238998","https://openalex.org/W2043236694","https://openalex.org/W2048430775","https://openalex.org/W2067054378","https://openalex.org/W2072180386","https://openalex.org/W2075228337","https://openalex.org/W2092074505","https://openalex.org/W2275326898","https://openalex.org/W2413469445"],"related_works":["https://openalex.org/W1968483820","https://openalex.org/W27304192","https://openalex.org/W2004851397","https://openalex.org/W2078492164","https://openalex.org/W2046855373","https://openalex.org/W1963694653","https://openalex.org/W245951208","https://openalex.org/W2137696087","https://openalex.org/W1977828463","https://openalex.org/W2079441503"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
