{"id":"https://openalex.org/W2001018340","doi":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","title":"Evolution of a B-Cell Lymphoma to Multiple Myeloma after Chemotherapy","display_name":"Evolution of a B-Cell Lymphoma to Multiple Myeloma after Chemotherapy","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2001018340","doi":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","mag":"2001018340","pmid":"https://pubmed.ncbi.nlm.nih.gov/15515600"},"language":"en","primary_location":{"id":"doi:10.1111/j.1939-1676.2004.tb02621.x","doi":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2004.tb02621.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2004.tb02621.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114045535","display_name":"Robert C. Burnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C Burnett","raw_affiliation_strings":["Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110412123","display_name":"Mary Kay Blake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Kay Blake","raw_affiliation_strings":["College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO","Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO","Veterinary Cancer Referral Group, Tustin, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Veterinary Cancer Referral Group, Tustin, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Laura J Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura J Thompson","raw_affiliation_strings":["Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103935562","display_name":"Paul R. Avery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul R Avery","raw_affiliation_strings":["Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010002514","display_name":"Anne C. Avery","orcid":"https://orcid.org/0000-0002-0163-6495","observed_orcids":["https://orcid.org/0000-0002-0163-6495"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne C Avery","raw_affiliation_strings":["Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Microbiology, , Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010002514"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":0.5002,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.68365622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"5","first_page":"768","last_page":"768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.3005000054836273,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.1559000015258789,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/second-neoplasms","display_name":"second neoplasms","score":0.8080000281333923},{"id":"https://openalex.org/keywords/clonal-relatedness","display_name":"clonal relatedness","score":0.828000009059906},{"id":"https://openalex.org/keywords/immunoglobulin-gene-rearrangement","display_name":"immunoglobulin gene rearrangement","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5789999961853027},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.4259999990463257},{"id":"https://openalex.org/keywords/multicentric-lymphoma","display_name":"multicentric lymphoma","score":0.7369999885559082},{"id":"https://openalex.org/keywords/shetland-sheepdog","display_name":"Shetland sheepdog","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5426169037818909},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.430152028799057},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.32596126198768616},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012712","descriptor_name":"Serum Globulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1939-1676.2004.tb02621.x","doi":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2004.tb02621.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"doi:10.1892/0891-6640(2004)18<768:eoablt>2.0.co;2","doi":"https://doi.org/10.1892/0891-6640(2004)18<768:eoablt>2.0.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1892/0891-6640(2004)18<768:eoablt>2.0.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"pmid:15515600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15515600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary internal medicine","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1111/j.1939-1676.2004.tb02621.x","doi":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2004.tb02621.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2004.tb02621.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306437","display_name":"Morris Animal Foundation","ror":"https://ror.org/05pg13f04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2001018340.pdf","grobid_xml":"https://content.openalex.org/works/W2001018340.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W79383600","https://openalex.org/W1579870652","https://openalex.org/W1988970958","https://openalex.org/W1991031155","https://openalex.org/W2031737309","https://openalex.org/W2079162000","https://openalex.org/W2087373026","https://openalex.org/W2146513847","https://openalex.org/W2244873192"],"related_works":["https://openalex.org/W2023970738","https://openalex.org/W2003338281","https://openalex.org/W2083848917","https://openalex.org/W2400873163","https://openalex.org/W2019795158","https://openalex.org/W1977998153","https://openalex.org/W2067073543","https://openalex.org/W2027493447","https://openalex.org/W79383600","https://openalex.org/W2558175853"],"abstract_inverted_index":{"econd":[0],"hematopoietic":[1],"malignancies":[2],"have":[3,19,172,203,228],"been":[4],"reportedafter":[5],"treatment":[6],"for":[7,253,308],"a":[8,20,25,35,50,112,133,145,238,326],"variety":[9],"of":[10,58,63,81,84,94,111,142,144,159,280],"human":[11],"lymphomas":[12],"and":[13,23,76,149,223,310,317,319,329,335],"leukemias.Often":[14],"the":[15,92,95,109,117,123,127,140,160,164,168,173,181,214,219,229,232,260,277,281,286,300,322],"2nd":[16,113,118],"neoplasm":[17,148],"will":[18],"higher":[21],"grade":[22],"exhibit":[24],"more":[26,51,146,153],"aggressive":[27,104,154],"clinical":[28,40,53,249],"course.For":[29],"example,":[30],"splenic":[31],"marginal":[32],"zone":[33],"lymphoma,":[34],"disease":[36,252,267],"with":[37,49,243,263],"an":[38],"indolent":[39],"course,":[41],"can":[42,194],"progress":[43],"to":[44,299],"large":[45,182],"cell":[46],"B-cell":[47,183],"lymphoma":[48,65,97,184],"malignant":[52],"course":[54],"in":[55,66,78,89,180,247,271,290],"approximately":[56,79,254],"10%":[57],"cases.":[59],"1":[60],"The":[61],"development":[62,110],"large-cell":[64,96],"humans":[67,90],"after":[68,91,273],"chronic":[69,85,169],"lymphocytic":[70,86,170],"leukemia":[71,171],"is":[72,98,115,120,132],"called":[73],"Richter's":[74,156],"syndrome":[75],"occurs":[77],"3%":[80],"all":[82],"cases":[83],"leukemia.2":[87],"Survival":[88],"appearance":[93],"less":[99],"than":[100],"6":[101,274],"months":[102],"despite":[103],"treatment.An":[105],"important":[106],"question":[107],"about":[108],"malignancy":[114],"whether":[116],"tumor":[119],"derived":[121],"from":[122,251],"same":[124,174,230],"clone":[125],"as":[126,177],"original":[128],"or":[129,152,211],"if":[130],"it":[131],"new":[134],"primary":[135],"malignancy.The":[136],"former":[137],"may":[138],"be":[139,195],"result":[141],"selection":[143],"drug-resistant":[147],"require":[150],"alternative":[151],"chemotherapy.In":[155],"syndrome,":[157],"most":[158],"evidence":[161],"suggests":[162],"that":[163,185,200,225,240],"neoplastic":[165],"cells":[166],"comprising":[167],"clonal":[175,278],"origin":[176],"those":[178],"found":[179],"develops":[186],"later.":[187],"2":[188,192,282],"Clonal":[189],"relatedness":[190,279],"between":[191],"tumors":[193,202,227,283],"established":[196],"either":[197],"by":[198,208,212,284],"demonstrating":[199],"both":[201,226],"similarly":[204],"rearranged":[205],"immunoglobulin":[206,220,287],"genes":[207],"Southern":[209],"blotting":[210],"sequencing":[213,285],"deoxyribonucleic":[215],"acid":[216],"(DNA)":[217],"encoding":[218],"hypervariable":[221],"region":[222],"showing":[224],"sequence.In":[231],"present":[233],"case":[234],"report,":[235],"we":[236],"describe":[237],"dog":[239,261],"presented":[241,298],"initially":[242],"multicentric":[244],"lymphoma.Treatment":[245],"resulted":[246],"complete":[248],"remission":[250],"3":[255],"months,":[256],"at":[257,304],"which":[258],"time":[259],"re-presented":[262],"multiple":[264],"myeloma.The":[265],"dog's":[266],"progressed":[268],"rapidly,":[269],"resulting":[270],"euthanasia":[272],"weeks.We":[275],"investigated":[276],"gene":[288],"rearrangements":[289],"each.A":[291],"12-year-old":[292],"22-kg":[293],"male":[294],"neutered":[295],"Shetland":[296],"Sheepdog":[297],"Veterinary":[301],"Teaching":[302],"Hospital":[303],"Colorado":[305],"State":[306],"University":[307],"weakness":[309],"lethargy.Physical":[311],"exam":[312],"revealed":[313,325],"generalized":[314],"lymphadenopathy,":[315],"hepatomegaly":[316],"splenomegaly,":[318,334],"bruising":[320],"on":[321],"ventral":[323],"abdomen.Radiographs":[324],"normal":[327],"thorax,":[328],"abdominal":[330],"ultrasound":[331],"showed":[332],"hepatomegaly,":[333],"sublumbar":[336]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}