{"id":"https://openalex.org/W2001014081","doi":"https://doi.org/10.3109/15622975.2011.562244","title":"A meta-analysis of circulating BDNF concentrations in anorexia nervosa","display_name":"A meta-analysis of circulating BDNF concentrations in anorexia nervosa","publication_year":2011,"publication_date":"2011-04-12","ids":{"openalex":"https://openalex.org/W2001014081","doi":"https://doi.org/10.3109/15622975.2011.562244","mag":"2001014081","pmid":"https://pubmed.ncbi.nlm.nih.gov/21486106"},"language":"en","primary_location":{"id":"doi:10.3109/15622975.2011.562244","doi":"https://doi.org/10.3109/15622975.2011.562244","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15622975.2011.562244","pdf_url":null,"source":{"id":"https://openalex.org/S68933629","display_name":"The World Journal of Biological Psychiatry","issn_l":"1562-2975","issn":["1562-2975","1814-1412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The World Journal of Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055961312","display_name":"Marek K. Brandys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210154893","display_name":"Altrecht GGZ","ror":"https://ror.org/050jqep38","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210154893"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marek K. Brandys","raw_affiliation_strings":["Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands","Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute,\nZeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute,\nZeist, The Netherlands","institution_ids":["https://openalex.org/I4210154893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056480595","display_name":"Martien J. Kas","orcid":"https://orcid.org/0000-0002-4471-8618","observed_orcids":["https://orcid.org/0000-0002-4471-8618"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martien J. H. Kas","raw_affiliation_strings":["Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041310038","display_name":"Annemarie A. Van Elburg","orcid":"https://orcid.org/0000-0002-8745-4763","observed_orcids":["https://orcid.org/0000-0002-8745-4763"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210154893","display_name":"Altrecht GGZ","ror":"https://ror.org/050jqep38","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210154893"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Annemarie A. van Elburg","raw_affiliation_strings":["Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands; Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands","Department of Child and Adolescent Psychiatry, University Medical Centre,\nUtrecht, The Netherlands","Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute,\nZeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands; Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, University Medical Centre,\nUtrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute,\nZeist, The Netherlands","institution_ids":["https://openalex.org/I4210154893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110221517","display_name":"Iain C. Campbell","orcid":"https://orcid.org/0000-0003-2776-2681","observed_orcids":["https://orcid.org/0000-0003-2776-2681"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iain C. Campbell","raw_affiliation_strings":["Section of Eating Disorders, Institute of Psychiatry, King's College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Eating Disorders, Institute of Psychiatry, King's College London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035433879","display_name":"Roger A.H. Adan","orcid":"https://orcid.org/0000-0001-8994-0661","observed_orcids":["https://orcid.org/0000-0001-8994-0661"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210154893","display_name":"Altrecht GGZ","ror":"https://ror.org/050jqep38","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210154893"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Roger A. H. Adan","raw_affiliation_strings":["Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands; Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands","Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht,\nUtrecht, The Netherlands","Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute,\nZeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands; Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht,\nUtrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute,\nZeist, The Netherlands","institution_ids":["https://openalex.org/I4210154893"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035433879"],"corresponding_institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210154893"],"apc_list":null,"apc_paid":null,"fwci":0.72,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.58231293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"6","first_page":"444","last_page":"454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12873","display_name":"Nutrition, Health and Food Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":0.9570000171661377},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.890999972820282},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/stress-responsivity","display_name":"stress responsivity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/reward-processing","display_name":"reward processing","score":0.7889999747276306},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5080000162124634},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2777031586","wikidata":"https://www.wikidata.org/wiki/Q131749","display_name":"Anorexia nervosa","level":3,"score":0.7910318970680237},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.6810137033462524},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.674491822719574},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6645396947860718},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.662398636341095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6201984882354736},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5267702341079712},{"id":"https://openalex.org/C28804328","wikidata":"https://www.wikidata.org/wiki/Q7623693","display_name":"Strictly standardized mean difference","level":3,"score":0.5133763551712036},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48341357707977295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39610376954078674},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3750542104244232},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.35564112663269043},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0706644058227539}],"mesh":[{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3109/15622975.2011.562244","doi":"https://doi.org/10.3109/15622975.2011.562244","is_oa":false,"landing_page_url":"https://doi.org/10.3109/15622975.2011.562244","pdf_url":null,"source":{"id":"https://openalex.org/S68933629","display_name":"The World Journal of Biological Psychiatry","issn_l":"1562-2975","issn":["1562-2975","1814-1412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The World Journal of Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:21486106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21486106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/4b203479-6787-4b3e-8cc4-306e6f0c91d8","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/4b203479-6787-4b3e-8cc4-306e6f0c91d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brandys, M K, Kas, M J H, van Elburg, A A, Campbell, I C & Adan, R A H 2011, 'A meta-analysis of circulating BDNF concentrations in anorexia nervosa', World Journal of Biological Psychiatry, vol. 12, no. 6, pp. 444 - 454. https://doi.org/10.3109/15622975.2011.562244","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W1491149536","https://openalex.org/W1524372020","https://openalex.org/W1555679702","https://openalex.org/W1579300888","https://openalex.org/W1850032865","https://openalex.org/W1932805014","https://openalex.org/W1965058833","https://openalex.org/W1965069010","https://openalex.org/W1965075385","https://openalex.org/W1967017538","https://openalex.org/W1967075670","https://openalex.org/W1969534686","https://openalex.org/W1970378578","https://openalex.org/W1972280500","https://openalex.org/W1974062404","https://openalex.org/W1974204788","https://openalex.org/W1975608455","https://openalex.org/W1979722180","https://openalex.org/W1980719669","https://openalex.org/W1981632099","https://openalex.org/W1981708397","https://openalex.org/W1982889157","https://openalex.org/W1986376495","https://openalex.org/W1988791308","https://openalex.org/W1991176673","https://openalex.org/W1999128166","https://openalex.org/W2000168892","https://openalex.org/W2002222487","https://openalex.org/W2003008123","https://openalex.org/W2003998738","https://openalex.org/W2009838896","https://openalex.org/W2010050518","https://openalex.org/W2011182388","https://openalex.org/W2011528345","https://openalex.org/W2014518719","https://openalex.org/W2016868853","https://openalex.org/W2018490846","https://openalex.org/W2018815299","https://openalex.org/W2020533179","https://openalex.org/W2023315468","https://openalex.org/W2023501491","https://openalex.org/W2025153944","https://openalex.org/W2025311391","https://openalex.org/W2027262024","https://openalex.org/W2028786180","https://openalex.org/W2028875570","https://openalex.org/W2028980996","https://openalex.org/W2030772848","https://openalex.org/W2031358273","https://openalex.org/W2031490046","https://openalex.org/W2033892184","https://openalex.org/W2038122755","https://openalex.org/W2041702995","https://openalex.org/W2042475669","https://openalex.org/W2043283741","https://openalex.org/W2044015546","https://openalex.org/W2046878213","https://openalex.org/W2051367276","https://openalex.org/W2051600135","https://openalex.org/W2052171331","https://openalex.org/W2054985002","https://openalex.org/W2059042482","https://openalex.org/W2059527510","https://openalex.org/W2063294463","https://openalex.org/W2064396921","https://openalex.org/W2065267852","https://openalex.org/W2066386560","https://openalex.org/W2067637201","https://openalex.org/W2067657652","https://openalex.org/W2070003250","https://openalex.org/W2083119172","https://openalex.org/W2086710154","https://openalex.org/W2088754913","https://openalex.org/W2090305824","https://openalex.org/W2097660315","https://openalex.org/W2098874330","https://openalex.org/W2100344731","https://openalex.org/W2107031757","https://openalex.org/W2107328434","https://openalex.org/W2111038577","https://openalex.org/W2120463322","https://openalex.org/W2125435699","https://openalex.org/W2126175461","https://openalex.org/W2132301575","https://openalex.org/W2132522309","https://openalex.org/W2133443154","https://openalex.org/W2134453207","https://openalex.org/W2137198040","https://openalex.org/W2137979524","https://openalex.org/W2139407404","https://openalex.org/W2146399707","https://openalex.org/W2147311167","https://openalex.org/W2150814938","https://openalex.org/W2152381439","https://openalex.org/W2156759015","https://openalex.org/W2157823046","https://openalex.org/W2157967363","https://openalex.org/W2160943547","https://openalex.org/W2161649767","https://openalex.org/W2163144326","https://openalex.org/W2163587018","https://openalex.org/W2164424529","https://openalex.org/W2166106170","https://openalex.org/W2166347822","https://openalex.org/W2170302032","https://openalex.org/W4300870773"],"related_works":["https://openalex.org/W2516643293","https://openalex.org/W2027262024","https://openalex.org/W7128441230","https://openalex.org/W4401411513","https://openalex.org/W3121365334","https://openalex.org/W2126175461","https://openalex.org/W7099673434","https://openalex.org/W4323108445","https://openalex.org/W3206967996","https://openalex.org/W2616346597"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Brain":[1],"derived":[2],"neurotrophic":[3],"factor":[4,50],"(BDNF)":[5],"is":[6,118,192],"involved":[7],"in":[8,11,26,38,51,69,75,85,100,125,182,195],"neuroplasticity,":[9],"and":[10,18,29,54,92,98,109,186,209,233,243],"the":[12,33,52,101,104,163,168,202,239],"homeostatic":[13],"regulation":[14],"of":[15,35,56,65,87,103,149,176,204,230],"food":[16],"intake":[17],"energy":[19],"expenditure.":[20],"It":[21],"also":[22],"has":[23],"a":[24],"role":[25],"stress":[27],"responsivity":[28],"reward":[30],"processing.":[31],"On":[32],"basis":[34],"its":[36],"involvement":[37],"these":[39],"various":[40],"processes,":[41],"BDNF":[42,67,84,123,180,205,232,242],"can":[43],"be":[44,47,223],"hypothesized":[45],"to":[46,77,127,144,162,222],"an":[48],"important":[49],"development":[53],"maintenance":[55],"anorexia":[57],"nervosa":[58],"(AN).":[59],"This":[60,113],"study":[61,114,166],"meta-analytically":[62],"summarizes":[63],"investigations":[64],"serum":[66,86,122],"concentrations":[68,181],"people":[70],"currently":[71],"ill":[72],"with":[73,89,120,184,201],"AN,":[74],"comparison":[76,126],"healthy":[78,93,128,187],"controls.":[79,129],"METHODS:":[80],"Seven":[81],"studies":[82,177],"measuring":[83,178],"individuals":[88],"AN":[90,117,185,244],"(n=155)":[91],"controls":[94,188],"(n=174)":[95],"were":[96],"identified":[97,153,208],"included":[99],"meta-analysis":[102],"mean":[105,135],"differences":[106],"between":[107,228,241],"case":[108],"control":[110],"groups.":[111],"RESULTS:":[112],"confirms":[115,189],"that":[116,190],"associated":[119,200],"decreased":[121],"concentrations,":[124],"The":[130,172],"combined":[131],"effect":[132,150],"size":[133],"(standardized":[134],"difference,":[136],"SMD)":[137],"was":[138,152],"large":[139],"(SMD=-0.96;":[140],"95%":[141],"CI":[142],"-1.33":[143],"-0.59;":[145],"P<0.001).":[146],"Significant":[147],"heterogeneity":[148],"sizes":[151],"(I(2)=58.3%;":[154],"P<0.001),":[155],"which":[156],"emerged":[157],"as":[158],"being":[159],"primarily":[160],"attributable":[161],"first":[164],"published":[165],"on":[167],"investigated":[169],"association.":[170],"CONCLUSIONS:":[171],"present":[173],"meta-analytical":[174],"summary":[175],"circulating":[179,231],"women":[183],"it":[191],"significantly":[193],"reduced":[194],"this":[196],"patient":[197],"group.":[198],"Difficulties":[199],"measurement":[203],"have":[206,213,245],"been":[207,214,246],"potential":[210],"confounding":[211],"factors":[212],"discussed.":[215],"Current":[216],"data":[217],"do":[218],"not":[219],"allow":[220],"inferences":[221],"made":[224],"about":[225],"causal":[226],"links":[227],"levels":[229],"AN.":[234],"However,":[235],"possible":[236],"explanations":[237],"for":[238],"relationship":[240],"presented.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
