{"id":"https://openalex.org/W2000999653","doi":"https://doi.org/10.1016/s1359-0278(96)00013-2","title":"Unfolded BPTI variants with a single disulfide bond have diminished non-native structure distant from the crosslink","display_name":"Unfolded BPTI variants with a single disulfide bond have diminished non-native structure distant from the crosslink","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2000999653","doi":"https://doi.org/10.1016/s1359-0278(96)00013-2","mag":"2000999653","pmid":"https://pubmed.ncbi.nlm.nih.gov/9079365"},"language":"en","primary_location":{"id":"doi:10.1016/s1359-0278(96)00013-2","doi":"https://doi.org/10.1016/s1359-0278(96)00013-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1359-0278(96)00013-2","pdf_url":null,"source":{"id":"https://openalex.org/S123786394","display_name":"Folding and Design","issn_l":"1359-0278","issn":["1359-0278","1878-5808"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folding and Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/s1359-0278(96)00013-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081917442","display_name":"Elisar J. Barbar","orcid":"https://orcid.org/0000-0003-4892-5259","observed_orcids":["https://orcid.org/0000-0003-4892-5259"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisar Barbar","raw_affiliation_strings":["Department of Biochemistry, University of Minnesota, St. Paul 55108, USA","Elisar Barbar and Clare Woodward, Department of Biochemistry, University of Minnesota, St. Paul, MN 55108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Minnesota, St. Paul 55108, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Elisar Barbar and Clare Woodward, Department of Biochemistry, University of Minnesota, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019782256","display_name":"George B\u00e1r\u00e1ny","orcid":"https://orcid.org/0000-0002-6373-2706","observed_orcids":["https://orcid.org/0000-0002-6373-2706"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Barany","raw_affiliation_strings":["George Barany, Department of Chemistry, University of Minnesota, Minneapolis, MN 5455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Barany, Department of Chemistry, University of Minnesota, Minneapolis, MN 5455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013399335","display_name":"Clare K. Woodward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clare Woodward","raw_affiliation_strings":["Elisar Barbar and Clare Woodward, Department of Biochemistry, University of Minnesota, St. Paul, MN 55108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elisar Barbar and Clare Woodward, Department of Biochemistry, University of Minnesota, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":1.1889,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.77335525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"1","issue":"1","first_page":"65","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aprotinin","display_name":"aprotinin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/beta-lactoglobulin","display_name":"\u03b2-lactoglobulin","score":0.47600001096725464},{"id":"https://openalex.org/keywords/unfolded-proteins","display_name":"unfolded proteins","score":0.4909999966621399},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.6890000104904175},{"id":"https://openalex.org/keywords/partially-folded-proteins","display_name":"partially folded proteins","score":0.5379999876022339},{"id":"https://openalex.org/keywords/antiparallel-beta-sheet","display_name":"antiparallel beta-sheet","score":0.7509999871253967},{"id":"https://openalex.org/keywords/chemical-exchange","display_name":"chemical exchange","score":0.6759999990463257},{"id":"https://openalex.org/keywords/folding-intermediates","display_name":"folding intermediates","score":0.6899999976158142},{"id":"https://openalex.org/keywords/denatured-state","display_name":"denatured state","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8355854749679565},{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.8273531198501587},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6343801021575928},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.6087589263916016},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.559639573097229},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.47197896242141724},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46472981572151184},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4523036777973175},{"id":"https://openalex.org/C19472624","wikidata":"https://www.wikidata.org/wiki/Q583851","display_name":"Native state","level":2,"score":0.4411359429359436},{"id":"https://openalex.org/C111429119","wikidata":"https://www.wikidata.org/wiki/Q899127","display_name":"Chemical shift","level":2,"score":0.43720391392707825},{"id":"https://openalex.org/C85641259","wikidata":"https://www.wikidata.org/wiki/Q290042","display_name":"Turn (biochemistry)","level":2,"score":0.4217604398727417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10649409890174866},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1359-0278(96)00013-2","doi":"https://doi.org/10.1016/s1359-0278(96)00013-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1359-0278(96)00013-2","pdf_url":null,"source":{"id":"https://openalex.org/S123786394","display_name":"Folding and Design","issn_l":"1359-0278","issn":["1359-0278","1878-5808"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folding and Design","raw_type":"journal-article"},{"id":"pmid:9079365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9079365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folding & design","raw_type":"Journal Article"},{"id":"pmid:9162141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9162141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folding & design","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s1359-0278(96)00013-2","doi":"https://doi.org/10.1016/s1359-0278(96)00013-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1359-0278(96)00013-2","pdf_url":null,"source":{"id":"https://openalex.org/S123786394","display_name":"Folding and Design","issn_l":"1359-0278","issn":["1359-0278","1878-5808"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folding and Design","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G371302465","display_name":null,"funder_award_id":"GM26242","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4259692265","display_name":null,"funder_award_id":"GM 51628","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4796740359","display_name":"SYNTHETIC STUDIES OF PROTEIN STABILITY AND FOLDING","funder_award_id":"R01GM051628","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7411713911","display_name":"SINGLE PROTON EXCHANGE KINETICS IN PROTEINS","funder_award_id":"R01GM026242","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1486842453","https://openalex.org/W1491642680","https://openalex.org/W1499789973","https://openalex.org/W1560339408","https://openalex.org/W1966024205","https://openalex.org/W1967953743","https://openalex.org/W1973566670","https://openalex.org/W1984916779","https://openalex.org/W1987711796","https://openalex.org/W1994277766","https://openalex.org/W1997624484","https://openalex.org/W2001107789","https://openalex.org/W2008708467","https://openalex.org/W2010580822","https://openalex.org/W2028231353","https://openalex.org/W2044397014","https://openalex.org/W2044873534","https://openalex.org/W2045950270","https://openalex.org/W2061831858","https://openalex.org/W2062973238","https://openalex.org/W2066281409","https://openalex.org/W2068303796","https://openalex.org/W2073084525","https://openalex.org/W2074770586","https://openalex.org/W2075044224","https://openalex.org/W2075116614","https://openalex.org/W2076831849","https://openalex.org/W2077986963","https://openalex.org/W2079492386","https://openalex.org/W2081205015","https://openalex.org/W2084168484","https://openalex.org/W2087849089","https://openalex.org/W2088706964","https://openalex.org/W2114304598","https://openalex.org/W2949250147","https://openalex.org/W4242009576"],"related_works":["https://openalex.org/W1044219057","https://openalex.org/W1983653817","https://openalex.org/W2061831858","https://openalex.org/W2023976496","https://openalex.org/W2147401554","https://openalex.org/W2075116614","https://openalex.org/W2013771354","https://openalex.org/W1560339408","https://openalex.org/W2172140322","https://openalex.org/W2044873534"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
