{"id":"https://openalex.org/W2000999322","doi":"https://doi.org/10.1210/jc.2006-0018","title":"Effects of Insulin Deprivation and Treatment on Homocysteine Metabolism in People with Type 1 Diabetes","display_name":"Effects of Insulin Deprivation and Treatment on Homocysteine Metabolism in People with Type 1 Diabetes","publication_year":2006,"publication_date":"2006-06-14","ids":{"openalex":"https://openalex.org/W2000999322","doi":"https://doi.org/10.1210/jc.2006-0018","mag":"2000999322","pmid":"https://pubmed.ncbi.nlm.nih.gov/16772348"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2006-0018","doi":"https://doi.org/10.1210/jc.2006-0018","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2006-0018","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089408415","display_name":"Haitham S. Abu-Lebdeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haitham S. Abu-Lebdeh","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086993822","display_name":"Rocco Barazzoni","orcid":"https://orcid.org/0000-0002-4049-2404","observed_orcids":["https://orcid.org/0000-0002-4049-2404"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rocco Barazzoni","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102995745","display_name":"Shon Meek","orcid":"https://orcid.org/0000-0002-1454-301X","observed_orcids":["https://orcid.org/0000-0002-1454-301X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shon E. Meek","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110811429","display_name":"Maureen L. Bigelow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen L. Bigelow","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108200855","display_name":"Xuan-Mai T. Persson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuan-Mai T. Persson","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002287349","display_name":"K. Sreekumaran Nair","orcid":"https://orcid.org/0000-0002-0649-9469","observed_orcids":["https://orcid.org/0000-0002-0649-9469"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Sreekumaran Nair","raw_affiliation_strings":["Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002287349"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.9016,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.89710611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"91","issue":"9","first_page":"3344","last_page":"3348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/homocysteine-metabolism","display_name":"homocysteine metabolism","score":0.9039999842643738},{"id":"https://openalex.org/keywords/insulin-deprivation","display_name":"insulin deprivation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/transsulfuration","display_name":"transsulfuration","score":0.9330000281333923},{"id":"https://openalex.org/keywords/remethylation","display_name":"remethylation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/transmethylation","display_name":"transmethylation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.5649999976158142},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6340000033378601},{"id":"https://openalex.org/keywords/stable-isotope-tracers","display_name":"stable isotope tracers","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2910648213","wikidata":"https://www.wikidata.org/wiki/Q7835367","display_name":"Transsulfuration","level":5,"score":0.974722146987915},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.8657231330871582},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8408275842666626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8381128311157227},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7455132603645325},{"id":"https://openalex.org/C28774466","wikidata":"https://www.wikidata.org/wiki/Q3774783","display_name":"Transmethylation","level":4,"score":0.7119465470314026},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.6731173992156982},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5048683285713196},{"id":"https://openalex.org/C16525657","wikidata":"https://www.wikidata.org/wiki/Q5201183","display_name":"Cystathionine beta synthase","level":4,"score":0.4051770567893982},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39579400420188904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3175731897354126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2589431703090668},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19309088587760925},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08319306373596191}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000597","descriptor_name":"Amino Acids, Branched-Chain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.2006-0018","doi":"https://doi.org/10.1210/jc.2006-0018","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2006-0018","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:16772348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16772348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:arts.units.it:11368/1844967","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11368/1844967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5918705860","display_name":"General Clinical Research Center","funder_award_id":"M01RR000585","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8426465610","display_name":null,"funder_award_id":"R01 DK4193","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000118427","display_name":null,"funder_award_id":"RR00585","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1808750587","https://openalex.org/W1943195050","https://openalex.org/W1963542379","https://openalex.org/W1968511421","https://openalex.org/W1976499979","https://openalex.org/W1988041601","https://openalex.org/W2030050942","https://openalex.org/W2037558340","https://openalex.org/W2049511789","https://openalex.org/W2057734459","https://openalex.org/W2062741774","https://openalex.org/W2071781967","https://openalex.org/W2082686044","https://openalex.org/W2090532057","https://openalex.org/W2109811121","https://openalex.org/W2110668771","https://openalex.org/W2112574664","https://openalex.org/W2137394317","https://openalex.org/W2164721380","https://openalex.org/W2166235806","https://openalex.org/W4250056216","https://openalex.org/W6638228456"],"related_works":["https://openalex.org/W2137394317","https://openalex.org/W2133818577","https://openalex.org/W2071781967","https://openalex.org/W7099896568","https://openalex.org/W172225629","https://openalex.org/W1964968311","https://openalex.org/W2165243795","https://openalex.org/W2128148614","https://openalex.org/W3173797870","https://openalex.org/W2142418974"],"abstract_inverted_index":{"CONTEXT:":[0],"Abnormal":[1],"homocysteine":[2,29,66,146,198,220,252],"metabolism":[3,17,41,67,227,247],"may":[4,215,253],"contribute":[5],"to":[6,36,49,101],"increased":[7,219],"cardiovascular":[8],"death":[9],"in":[10,20,44,68,105,171,202,232,242,248,258],"type":[11,259],"1":[12,260],"diabetes":[13],"(T1DM).":[14],"Amino":[15],"acid":[16],"is":[18,42],"altered":[19,43,251],"T1DM.":[21,45,69,235],"In":[22,165],"vitro,":[23],"insulin":[24,52,55,60,63,111,117,230,256],"reduces":[25],"hepatic":[26],"catabolism":[27],"of":[28,143,155,225,245],"by":[30,218],"inhibiting":[31],"liver":[32],"transsulfuration.":[33,221],"It":[34],"remains":[35],"be":[37,216],"determined":[38],"whether":[39,51],"methionine-homocysteine":[40,103,226,246],"OBJECTIVE:":[46],"We":[47,96],"sought":[48],"determine":[50],"deficiency":[53,257],"during":[54,110,116,209,229,255],"deprivation":[56,112,231],"or":[57],"high":[58],"plasma":[59,140],"concentration":[61],"after":[62],"treatment":[64,118,181],"alters":[65],"DESIGN:":[70],"This":[71],"was":[72,85],"an":[73],"acute":[74],"interventional":[75],"study":[76,84],"with":[77,108,123,234],"paired":[78],"and":[79,114,120,136,145,147,163,175,184,191,212,250],"comparative":[80],"controls.":[81],"SETTING:":[82],"The":[83],"conducted":[86],"at":[87],"a":[88,239],"general":[89],"clinical":[90],"research":[91],"center.":[92],"PATIENTS":[93],"AND":[94],"INTERVENTION:":[95],"used":[97],"stable":[98],"isotope":[99],"tracers":[100],"measure":[102],"kinetics":[104,133],"six":[106],"patients":[107],"T1DM":[109,150,203],"(I-)":[113,151],"also":[115],"(I+)":[119],"compared":[121],"them":[122],"nondiabetic":[124],"controls":[125,174],"(n":[126],"=":[127],"6).":[128],"MAIN":[129],"OUTCOME":[130],"MEASURES:":[131],"Homocysteine":[132],"(transmethylation,":[134],"transsulfuration,":[135],"remethylation)":[137],"were":[138,169,200],"from":[139],"isotopic":[141],"enrichment":[142],"methionine":[144],"(13)CO(2).":[148],"RESULTS:":[149],"had":[152],"lower":[153,201],"rates":[154,168],"homocysteine-methionine":[156],"remethylation":[157,185],"(P":[158,177,186,204],"<":[159,178,187,205],"0.05":[160,188,206],"vs.":[161,189,195,207],"control":[162,208],"I+).":[164],"contrast,":[166],"transsulfuration":[167,183],"higher":[170],"I-":[172,190,211],"than":[173],"I+":[176],"0.05).":[179],"Insulin":[180,237],"normalized":[182],"P":[192],">":[193],"0.8":[194],"control).":[196],"Plasma":[197],"concentrations":[199],"both":[210],"I+),":[213],"which":[214],"explained":[217],"Thus,":[222],"significant":[223],"alterations":[224],"occur":[228,254],"humans":[233],"CONCLUSIONS:":[236],"plays":[238],"key":[240],"role":[241],"the":[243],"regulation":[244],"humans,":[249],"diabetic":[261],"patients.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}