{"id":"https://openalex.org/W2000997117","doi":"https://doi.org/10.1139/o77-010","title":"Action of inhibitors on monoamine and diamine metabolism in the rat","display_name":"Action of inhibitors on monoamine and diamine metabolism in the rat","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2000997117","doi":"https://doi.org/10.1139/o77-010","mag":"2000997117","pmid":"https://pubmed.ncbi.nlm.nih.gov/402175"},"language":"en","primary_location":{"id":"doi:10.1139/o77-010","doi":"https://doi.org/10.1139/o77-010","is_oa":false,"landing_page_url":"https://doi.org/10.1139/o77-010","pdf_url":null,"source":{"id":"https://openalex.org/S4210188051","display_name":"Canadian Journal of Biochemistry","issn_l":"0008-4018","issn":["0008-4018"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108435632","display_name":"Theodore L. Sourkes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodore L. Sourkes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001761860","display_name":"Krystyna Missala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krystyna Missala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.922,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.68698087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":"1","first_page":"56","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibitors","display_name":"monoamine oxidase inhibitors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/monoamine-metabolism","display_name":"monoamine metabolism","score":0.6779999732971191},{"id":"https://openalex.org/keywords/tranylcypromine","display_name":"tranylcypromine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/clorgyline","display_name":"clorgyline","score":0.9929999709129333},{"id":"https://openalex.org/keywords/selegiline","display_name":"selegiline","score":0.9829999804496765},{"id":"https://openalex.org/keywords/aminoguanidine","display_name":"aminoguanidine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/iproniazid","display_name":"iproniazid","score":0.9660000205039978},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.996999979019165},{"id":"https://openalex.org/keywords/pargyline","display_name":"pargyline","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chelating-agents","display_name":"chelating agents","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C2778575451","wikidata":"https://www.wikidata.org/wiki/Q421368","display_name":"Iproniazid","level":4,"score":0.8135137557983398},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.8023528456687927},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.7883589267730713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7432411909103394},{"id":"https://openalex.org/C2910293678","wikidata":"https://www.wikidata.org/wiki/Q2889652","display_name":"Clorgyline","level":4,"score":0.7404403686523438},{"id":"https://openalex.org/C2777118369","wikidata":"https://www.wikidata.org/wiki/Q420885","display_name":"Tranylcypromine","level":4,"score":0.708641767501831},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.6425078511238098},{"id":"https://openalex.org/C2777067607","wikidata":"https://www.wikidata.org/wiki/Q781329","display_name":"Pargyline","level":4,"score":0.5663961172103882},{"id":"https://openalex.org/C2779053737","wikidata":"https://www.wikidata.org/wiki/Q414006","display_name":"Diamine oxidase","level":3,"score":0.5363138318061829},{"id":"https://openalex.org/C2780871995","wikidata":"https://www.wikidata.org/wiki/Q2500485","display_name":"Diamine","level":2,"score":0.49609479308128357},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44342225790023804},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4253942370414734},{"id":"https://openalex.org/C2781448169","wikidata":"https://www.wikidata.org/wiki/Q394317","display_name":"Agmatine","level":4,"score":0.41577446460723877},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3479202091693878},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3429808020591736},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28651535511016846},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20165520906448364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14126995205879211}],"mesh":[{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006631","descriptor_name":"Amine Oxidase (Copper-Containing)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011700","descriptor_name":"Putrescine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/o77-010","doi":"https://doi.org/10.1139/o77-010","is_oa":false,"landing_page_url":"https://doi.org/10.1139/o77-010","pdf_url":null,"source":{"id":"https://openalex.org/S4210188051","display_name":"Canadian Journal of Biochemistry","issn_l":"0008-4018","issn":["0008-4018"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:402175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/402175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1778132660","https://openalex.org/W1970163398","https://openalex.org/W1964282828","https://openalex.org/W2032356520","https://openalex.org/W19035109","https://openalex.org/W2059732007","https://openalex.org/W2046341367","https://openalex.org/W2068469392","https://openalex.org/W7048718097","https://openalex.org/W2331487911"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,5,7,18,31,46,74],"a":[3,83],"series":[4],"inhibitors":[6],"monoamine":[8],"oxidase":[9,14],"(EC":[10,15],"1.4.3.4)":[11],"and":[12,17,34,42,68],"diamine":[13],"1.4.3.6)":[16],"two":[19],"chelating":[20],"agents":[21],"were":[22],"studied":[23],"in":[24,82],"rats,":[25],"with":[26,49],"respect":[27],"to":[28,36],"the":[29,47,72],"catabolism":[30,73],"labeled":[32],"pentylamine":[33,64],"putrescine":[35,61,79],"radioactive":[37],"carbon":[38],"dioxide.":[39],"D-Tranylcypromine,":[40],"clorgyline,":[41],"deprenyl":[43],"inhibited":[44,60,78],"oxidation":[45],"monoamine,":[48],"essentially":[50],"no":[51],"effect":[52],"on":[53],"putrescine,":[54],"under":[55],"our":[56],"test":[57],"conditions.":[58],"Aminoguanidine":[59],"but":[62],"not":[63],"oxidation.":[65],"Iproniazid,":[66],"isoniazid,":[67],"Lilly":[69],"51641":[70],"affected":[71],"both":[75],"amines.":[76],"Pargyline":[77],"oxidation,":[80],"apparently":[81],"reversible":[84],"manner.":[85]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}