{"id":"https://openalex.org/W2000990460","doi":"https://doi.org/10.1021/jf501373a","title":"Monascin Attenuates Oxidative Stress-Mediated Lung Inflammation via Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-\u03b3) and Nuclear Factor-Erythroid 2 Related Factor 2 (Nrf-2) Modulation","display_name":"Monascin Attenuates Oxidative Stress-Mediated Lung Inflammation via Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-\u03b3) and Nuclear Factor-Erythroid 2 Related Factor 2 (Nrf-2) Modulation","publication_year":2014,"publication_date":"2014-05-27","ids":{"openalex":"https://openalex.org/W2000990460","doi":"https://doi.org/10.1021/jf501373a","mag":"2000990460","pmid":"https://pubmed.ncbi.nlm.nih.gov/24865672"},"language":"en","primary_location":{"id":"doi:10.1021/jf501373a","doi":"https://doi.org/10.1021/jf501373a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf501373a","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066953235","display_name":"Wei-Hsuan Hsu","orcid":"https://orcid.org/0000-0002-6598-6435","observed_orcids":["https://orcid.org/0000-0002-6598-6435"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Hsuan Hsu","raw_affiliation_strings":["Department\rof Biochemical\rScience and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Biochemical\rScience and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048830060","display_name":"Bao\u2010Hong Lee","orcid":"https://orcid.org/0009-0006-3049-6010","observed_orcids":["https://orcid.org/0009-0006-3049-6010","https://orcid.org/0000-0002-1444-9760"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bao-Hong Lee","raw_affiliation_strings":["Department\rof Biochemical\rScience and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Biochemical\rScience and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025628943","display_name":"Tzu\u2010Ming Pan","orcid":"https://orcid.org/0000-0002-9865-1893","observed_orcids":["https://orcid.org/0000-0002-9865-1893"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tzu-Ming Pan","raw_affiliation_strings":["Department\rof Biochemical\rScience and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Biochemical\rScience and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025628943"],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8812,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.69359769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"23","first_page":"5337","last_page":"5344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.3935999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monascin","display_name":"monascin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/monascus","display_name":"Monascus","score":0.6579999923706055},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9139999747276306},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8799999952316284},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9819999933242798},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7640091180801392},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.7609262466430664},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7215772867202759},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6181915402412415},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5393073558807373},{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.5142104625701904},{"id":"https://openalex.org/C130241916","wikidata":"https://www.wikidata.org/wiki/Q20970208","display_name":"Peroxisome proliferator-activated receptor gamma","level":4,"score":0.4196723401546478},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4178123474121094},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4052087664604187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40370553731918335},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3801843822002411},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3274223208427429},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26073455810546875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20738160610198975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16673356294631958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006575","descriptor_name":"Heterocyclic Compounds, 3-Ring","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006575","descriptor_name":"Heterocyclic Compounds, 3-Ring","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032741","descriptor_name":"Monascus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032741","descriptor_name":"Monascus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jf501373a","doi":"https://doi.org/10.1021/jf501373a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf501373a","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:24865672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24865672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1824737122","https://openalex.org/W1985361042","https://openalex.org/W1989309894","https://openalex.org/W1990413035","https://openalex.org/W1994994450","https://openalex.org/W1999051300","https://openalex.org/W1999113566","https://openalex.org/W2003115027","https://openalex.org/W2006228166","https://openalex.org/W2006598330","https://openalex.org/W2008201503","https://openalex.org/W2021766187","https://openalex.org/W2024476729","https://openalex.org/W2029759541","https://openalex.org/W2030386807","https://openalex.org/W2031679199","https://openalex.org/W2033548993","https://openalex.org/W2039193485","https://openalex.org/W2041894177","https://openalex.org/W2044521211","https://openalex.org/W2044895791","https://openalex.org/W2049247238","https://openalex.org/W2051309543","https://openalex.org/W2052818964","https://openalex.org/W2064452102","https://openalex.org/W2068135486","https://openalex.org/W2076485183","https://openalex.org/W2090485914","https://openalex.org/W2092067512","https://openalex.org/W2098114974","https://openalex.org/W2099466528","https://openalex.org/W2111251212","https://openalex.org/W2124569198","https://openalex.org/W2131017515","https://openalex.org/W2138500715","https://openalex.org/W2146558971","https://openalex.org/W2147243248","https://openalex.org/W2158843488","https://openalex.org/W2313252270","https://openalex.org/W2315481467","https://openalex.org/W2318301929","https://openalex.org/W2333157744","https://openalex.org/W2344493390","https://openalex.org/W2414440248","https://openalex.org/W4322715312"],"related_works":["https://openalex.org/W2029759541","https://openalex.org/W2068135486","https://openalex.org/W1972012269","https://openalex.org/W2905453433","https://openalex.org/W2106601190","https://openalex.org/W2060036464","https://openalex.org/W3016624738","https://openalex.org/W1977768637","https://openalex.org/W1999113566","https://openalex.org/W1928375173"],"abstract_inverted_index":{"We":[0,67],"speculated":[1],"that":[2,50],"peroxisome":[3],"proliferator-activated":[4],"receptor":[5],"(PPAR)-\u03b3":[6],"agonists":[7],"may":[8,52],"modulate":[9],"the":[10,16],"oxidative":[11,32,141],"stress":[12],"pathway":[13],"to":[14,47,72,138],"ameliorate":[15],"development":[17],"of":[18,23,106],"airway":[19],"inflammation.":[20,132,142],"The":[21,103],"effect":[22],"Monascus-fermented":[24],"metabolite":[25],"monascin":[26],"(MS)":[27],"and":[28,40,58,80,125,136],"rosiglitazone":[29],"(Rosi)":[30],"on":[31],"stress-induced":[33],"lung":[34,76,131,140],"inflammation":[35,74],"was":[36,108],"evaluated.":[37],"Luciferase":[38],"assay":[39,44],"DNA":[41],"binding":[42],"activity":[43],"were":[45],"used":[46,68],"point":[48],"out":[49],"MS":[51,79,107,114,133],"be":[53],"a":[54],"novel":[55],"PPAR-\u03b3":[56,91,124,135],"agonist":[57],"nuclear":[59,99],"factor-erythroid":[60],"2":[61,64],"related":[62],"factor":[63,100],"(Nrf-2)":[65],"activator.":[66],"hydrogen":[69],"peroxide":[70],"(H2O2)":[71],"induce":[73],"in":[75,86],"epithelial":[77,88],"cells.":[78],"Rosi":[81],"prevented":[82],"H2O2-induced":[83],"ROS":[84],"generation":[85],"A549":[87],"cells":[89],"through":[90],"translocation,":[92],"avoiding":[93],"inflammatory":[94],"mediator":[95],"expression":[96,119],"via":[97,120],"inhibiting":[98],"(NF)-\u03baB":[101],"translocation.":[102],"regulatory":[104],"ability":[105],"abolished":[109],"by":[110],"siRNA":[111],"against":[112,130],"PPAR-\u03b3.":[113],"also":[115],"elevated":[116],"antioxidant":[117],"enzyme":[118],"Nrf-2":[121,126,137],"activation.":[122],"Both":[123],"might":[127],"have":[128],"benefits":[129],"regulated":[134],"improve":[139]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
