{"id":"https://openalex.org/W2000987318","doi":"https://doi.org/10.1016/j.biomaterials.2013.01.006","title":"Injectable intratumoral hydrogel as 5-fluorouracil drug depot","display_name":"Injectable intratumoral hydrogel as 5-fluorouracil drug depot","publication_year":2013,"publication_date":"2013-01-20","ids":{"openalex":"https://openalex.org/W2000987318","doi":"https://doi.org/10.1016/j.biomaterials.2013.01.006","mag":"2000987318","pmid":"https://pubmed.ncbi.nlm.nih.gov/23343635"},"language":"en","primary_location":{"id":"doi:10.1016/j.biomaterials.2013.01.006","doi":"https://doi.org/10.1016/j.biomaterials.2013.01.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2013.01.006","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075773952","display_name":"Hyo Won Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyo Won Seo","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002346770","display_name":"Da Yeon Kim","orcid":"https://orcid.org/0000-0003-4696-0501","observed_orcids":["https://orcid.org/0000-0003-4696-0501"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Da Yeon Kim","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006102362","display_name":"Doo Yeon Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Doo Yeon Kwon","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041136404","display_name":"Jin Seon Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Seon Kwon","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075399740","display_name":"Ling Mei Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ling Mei Jin","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010360747","display_name":"Bong Han Lee","orcid":"https://orcid.org/0009-0003-7936-5327","observed_orcids":["https://orcid.org/0009-0003-7936-5327"]},"institutions":[{"id":"https://openalex.org/I8991828","display_name":"Pukyong National University","ror":"https://ror.org/0433kqc49","country_code":"KR","type":"education","lineage":["https://openalex.org/I8991828"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bong Lee","raw_affiliation_strings":["Department of Polymer Engineering, Pukyong National University, Busan 608-739, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Polymer Engineering, Pukyong National University, Busan 608-739, Republic of Korea","institution_ids":["https://openalex.org/I8991828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649967","display_name":"Jae Ho Kim","orcid":"https://orcid.org/0000-0003-4323-4790","observed_orcids":["https://orcid.org/0000-0003-4323-4790"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Ho Kim","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103997996","display_name":"Byoung Hyun Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Hyun Min","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072408448","display_name":"Moon Suk Kim","orcid":"https://orcid.org/0000-0002-6689-1825","observed_orcids":["https://orcid.org/0000-0002-6689-1825","https://orcid.org/0000-0001-9281-7111"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Moon Suk Kim","raw_affiliation_strings":["Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Science and Technology, Ajou University, Suwon 443-759, Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072408448"],"corresponding_institution_ids":["https://openalex.org/I57664883"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":3.9936,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.93824947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"11","first_page":"2748","last_page":"2757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intratumoral-delivery","display_name":"intratumoral drug delivery","score":0.9129999876022339},{"id":"https://openalex.org/keywords/injectable-hydrogel","display_name":"injectable hydrogel","score":0.9700000286102295},{"id":"https://openalex.org/keywords/drug-depot","display_name":"drug depot","score":0.5590000152587891},{"id":"https://openalex.org/keywords/tumor-accumulation","display_name":"tumor accumulation","score":0.4880000054836273},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.7519999742507935},{"id":"https://openalex.org/keywords/systemic-toxicity-reduction","display_name":"systemic toxicity reduction","score":0.6349999904632568},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7988816499710083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6192277669906616},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6061248779296875},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.5770773887634277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.490105003118515},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.48675107955932617},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4865073561668396},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41578441858291626},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3265776038169861},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3233129382133484},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1761493980884552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14739257097244263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06884950399398804},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biomaterials.2013.01.006","doi":"https://doi.org/10.1016/j.biomaterials.2013.01.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2013.01.006","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},{"id":"pmid:23343635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23343635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ajou.ac.kr:201003/10199","doi":null,"is_oa":false,"landing_page_url":"http://repository.ajou.ac.kr/handle/201003/10199","pdf_url":null,"source":{"id":"https://openalex.org/S4306401331","display_name":"AJOU Open Repository (Ajou University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57664883","host_organization_name":"Ajou University","host_organization_lineage":["https://openalex.org/I57664883"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1447148458","display_name":null,"funder_award_id":"2010-0002170","funder_id":"https://openalex.org/F4320321640","funder_display_name":"Ministry of Knowledge Economy"},{"id":"https://openalex.org/G4173046139","display_name":null,"funder_award_id":"2010-0028294","funder_id":"https://openalex.org/F4320321640","funder_display_name":"Ministry of Knowledge Economy"},{"id":"https://openalex.org/G6448988204","display_name":null,"funder_award_id":"10038665","funder_id":"https://openalex.org/F4320321640","funder_display_name":"Ministry of Knowledge Economy"}],"funders":[{"id":"https://openalex.org/F4320321640","display_name":"Ministry of Knowledge Economy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1983708297","https://openalex.org/W1986175371","https://openalex.org/W1989989015","https://openalex.org/W1998050251","https://openalex.org/W2006038382","https://openalex.org/W2007315663","https://openalex.org/W2032866974","https://openalex.org/W2054310958","https://openalex.org/W2068327773","https://openalex.org/W2072639035","https://openalex.org/W2092801629","https://openalex.org/W2093250719","https://openalex.org/W2105289982","https://openalex.org/W2118354917","https://openalex.org/W2129106314","https://openalex.org/W2135423900","https://openalex.org/W2152676524","https://openalex.org/W2162830031","https://openalex.org/W2168465208","https://openalex.org/W2411908634"],"related_works":["https://openalex.org/W2262119483","https://openalex.org/W2078154719","https://openalex.org/W2068327773","https://openalex.org/W1976757122","https://openalex.org/W2393703658","https://openalex.org/W2345864426","https://openalex.org/W2029739158","https://openalex.org/W2542049839","https://openalex.org/W2000465180","https://openalex.org/W1989989015"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}