{"id":"https://openalex.org/W2000984699","doi":"https://doi.org/10.1007/s00249-006-0092-4","title":"Gene delivery by cationic lipid vectors: overcoming cellular barriers","display_name":"Gene delivery by cationic lipid vectors: overcoming cellular barriers","publication_year":2006,"publication_date":"2006-09-22","ids":{"openalex":"https://openalex.org/W2000984699","doi":"https://doi.org/10.1007/s00249-006-0092-4","mag":"2000984699","pmid":"https://pubmed.ncbi.nlm.nih.gov/17019592"},"language":"en","primary_location":{"id":"doi:10.1007/s00249-006-0092-4","doi":"https://doi.org/10.1007/s00249-006-0092-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00249-006-0092-4","pdf_url":null,"source":{"id":"https://openalex.org/S200539529","display_name":"European Biophysics Journal","issn_l":"0175-7571","issn":["0175-7571","1432-1017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Biophysics Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2000984699"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072623600","display_name":"Inge S. Zuhorn","orcid":"https://orcid.org/0000-0002-7695-915X","observed_orcids":["https://orcid.org/0000-0002-7695-915X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Inge S. Zuhorn","raw_affiliation_strings":["Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113989666","display_name":"Jan B. F. N. Engberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan B. F. N. Engberts","raw_affiliation_strings":["Physical Organic Chemistry Unit, Stratingh Institute, University of Groningen, Groningen, The Netherlands","Synthetic Organic Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Organic Chemistry Unit, Stratingh Institute, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"Synthetic Organic Chemistry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067826648","display_name":"Dick Hoekstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Dick Hoekstra","raw_affiliation_strings":["Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067826648"],"corresponding_institution_ids":["https://openalex.org/I1334415907"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":null,"fwci":1.2585,"has_fulltext":false,"cited_by_count":224,"citation_normalized_percentile":{"value":0.7642527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"36","issue":"4-5","first_page":"349","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lipoplexes","display_name":"lipoplexes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.7379999756813049},{"id":"https://openalex.org/keywords/membrane-perturbation","display_name":"membrane perturbation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.6520000100135803},{"id":"https://openalex.org/keywords/intracellular-trafficking","display_name":"intracellular trafficking","score":0.49300000071525574},{"id":"https://openalex.org/keywords/targeted-delivery","display_name":"targeted delivery","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.7649272680282593},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7598491311073303},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.754006564617157},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6425275206565857},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.6343898177146912},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5085517168045044},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49286556243896484},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.48920679092407227},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4831204116344452},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.4656909704208374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4566986858844757},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45165008306503296},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4461098611354828},{"id":"https://openalex.org/C205365616","wikidata":"https://www.wikidata.org/wiki/Q16863771","display_name":"Membrane biology","level":3,"score":0.41708922386169434},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4106200933456421},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37500816583633423},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3615463674068451},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3125365972518921},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17020606994628906},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12906122207641602},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014677","descriptor_name":"Pharmaceutical Vehicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00249-006-0092-4","doi":"https://doi.org/10.1007/s00249-006-0092-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00249-006-0092-4","pdf_url":null,"source":{"id":"https://openalex.org/S200539529","display_name":"European Biophysics Journal","issn_l":"0175-7571","issn":["0175-7571","1432-1017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Biophysics Journal","raw_type":"journal-article"},{"id":"pmid:17019592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17019592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European biophysics journal : EBJ","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/6a95bcc2-eb9b-4833-8777-7162b8da245f","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/6a95bcc2-eb9b-4833-8777-7162b8da245f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zuhorn, I S, Engberts, J B F N & Hoekstra, D 2007, 'Gene delivery by cationic lipid vectors : overcoming cellular barriers', European biophysics journal with biophysics letters, vol. 36, no. 4-5, pp. 349-362. https://doi.org/10.1007/s00249-006-0092-4","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:rug:oai:pure.rug.nl:publications/6a95bcc2-eb9b-4833-8777-7162b8da245f","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/6a95bcc2-eb9b-4833-8777-7162b8da245f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European biophysics journal with biophysics letters, 36(4-5), 349 - 362. SPRINGER","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W141441361","https://openalex.org/W1547069313","https://openalex.org/W1574617085","https://openalex.org/W1575798288","https://openalex.org/W1579604458","https://openalex.org/W1587227490","https://openalex.org/W1626964042","https://openalex.org/W1965680025","https://openalex.org/W1968913592","https://openalex.org/W1971741270","https://openalex.org/W1973123208","https://openalex.org/W1973933701","https://openalex.org/W1976811878","https://openalex.org/W1979329215","https://openalex.org/W1981675290","https://openalex.org/W1982313038","https://openalex.org/W1988537267","https://openalex.org/W1988568170","https://openalex.org/W1988578280","https://openalex.org/W1994354502","https://openalex.org/W1995529694","https://openalex.org/W1996139192","https://openalex.org/W1997181834","https://openalex.org/W1999199520","https://openalex.org/W2003542859","https://openalex.org/W2009872788","https://openalex.org/W2010655741","https://openalex.org/W2030428972","https://openalex.org/W2033974379","https://openalex.org/W2034342858","https://openalex.org/W2036331194","https://openalex.org/W2037358084","https://openalex.org/W2037595752","https://openalex.org/W2038122461","https://openalex.org/W2043878441","https://openalex.org/W2044211491","https://openalex.org/W2044696771","https://openalex.org/W2047516370","https://openalex.org/W2048674403","https://openalex.org/W2049624297","https://openalex.org/W2049905451","https://openalex.org/W2050705579","https://openalex.org/W2050891199","https://openalex.org/W2050992950","https://openalex.org/W2051242890","https://openalex.org/W2054441521","https://openalex.org/W2055722933","https://openalex.org/W2056560999","https://openalex.org/W2057576065","https://openalex.org/W2058811553","https://openalex.org/W2060831721","https://openalex.org/W2061379024","https://openalex.org/W2062602011","https://openalex.org/W2063668324","https://openalex.org/W2066582329","https://openalex.org/W2071531515","https://openalex.org/W2071732315","https://openalex.org/W2071885078","https://openalex.org/W2073822172","https://openalex.org/W2073831807","https://openalex.org/W2075846851","https://openalex.org/W2076223581","https://openalex.org/W2080648192","https://openalex.org/W2081030263","https://openalex.org/W2082168590","https://openalex.org/W2088812802","https://openalex.org/W2088922715","https://openalex.org/W2091955078","https://openalex.org/W2092447252","https://openalex.org/W2092568903","https://openalex.org/W2092770422","https://openalex.org/W2102066434","https://openalex.org/W2105277037","https://openalex.org/W2110885272","https://openalex.org/W2113888821","https://openalex.org/W2113972541","https://openalex.org/W2119591046","https://openalex.org/W2120862472","https://openalex.org/W2122352251","https://openalex.org/W2127273201","https://openalex.org/W2136296438","https://openalex.org/W2136634346","https://openalex.org/W2138765630","https://openalex.org/W2141899688","https://openalex.org/W2143668756","https://openalex.org/W2147584970","https://openalex.org/W2151142281","https://openalex.org/W2152515195","https://openalex.org/W2156122217","https://openalex.org/W2161268688","https://openalex.org/W2162194950","https://openalex.org/W2165852855","https://openalex.org/W2166013785","https://openalex.org/W2167551641","https://openalex.org/W2169678660","https://openalex.org/W2170027166","https://openalex.org/W2323505647","https://openalex.org/W2330884341","https://openalex.org/W3135190686","https://openalex.org/W4254663975"],"related_works":["https://openalex.org/W2000130544","https://openalex.org/W2117117603","https://openalex.org/W2356353547","https://openalex.org/W2115847832","https://openalex.org/W1522705129","https://openalex.org/W4253747558","https://openalex.org/W2070893548","https://openalex.org/W1997446043","https://openalex.org/W1830293915","https://openalex.org/W2149182742"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}