{"id":"https://openalex.org/W2000983089","doi":"https://doi.org/10.1083/jcb.123.4.993","title":"Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.","display_name":"Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.","publication_year":1993,"publication_date":"1993-11-15","ids":{"openalex":"https://openalex.org/W2000983089","doi":"https://doi.org/10.1083/jcb.123.4.993","mag":"2000983089","pmid":"https://pubmed.ncbi.nlm.nih.gov/8227154","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2200138"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.123.4.993","doi":"https://doi.org/10.1083/jcb.123.4.993","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.123.4.993","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2200138/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049924632","display_name":"Jeffrey D. Hildebrand","orcid":"https://orcid.org/0000-0002-6173-7052","observed_orcids":["https://orcid.org/0000-0002-6173-7052"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Hildebrand","raw_affiliation_strings":["Department of Microbiology, University of Virginia, Charlottesville 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia, Charlottesville 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051634622","display_name":"Michael D. Schaller","orcid":"https://orcid.org/0000-0003-3945-5208","observed_orcids":["https://orcid.org/0000-0003-3945-5208"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M D Schaller","raw_affiliation_strings":["Department of Microbiology, University of Virginia, Charlottesville 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia, Charlottesville 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113577837","display_name":"J. Thomas Parsons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J T Parsons","raw_affiliation_strings":["Department of Microbiology, University of Virginia, Charlottesville 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia, Charlottesville 22908","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":8.617,"has_fulltext":true,"cited_by_count":404,"citation_normalized_percentile":{"value":0.98711063,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"123","issue":"4","first_page":"993","last_page":"1005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pp125fak","display_name":"pp125FAK","score":0.996999979019165},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8989999890327454},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9070000052452087},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.7979999780654907},{"id":"https://openalex.org/keywords/oncogene-activation","display_name":"oncogene activation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/phosphatase","display_name":"phosphatase","score":0.6399999856948853},{"id":"https://openalex.org/keywords/extracellular-matrix-adhesion","display_name":"extracellular matrix adhesion","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.9451664686203003},{"id":"https://openalex.org/C108391706","wikidata":"https://www.wikidata.org/wiki/Q15333532","display_name":"PTK2","level":5,"score":0.9023003578186035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7712802290916443},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7162556648254395},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7032247185707092},{"id":"https://openalex.org/C116581196","wikidata":"https://www.wikidata.org/wiki/Q14906591","display_name":"Paxillin","level":4,"score":0.615228533744812},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5746269822120667},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4558675289154053},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4457378089427948},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.4387485682964325},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3651311993598938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23861655592918396},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.17661458253860474},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.13401326537132263},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.07557713985443115}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.123.4.993","doi":"https://doi.org/10.1083/jcb.123.4.993","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.123.4.993","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2200138","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2200138/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2200138/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:8227154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8227154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2200138","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2200138/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2200138/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2763080502","display_name":null,"funder_award_id":"CA 29243","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4268782045","display_name":"Signal Transduction in Time and Space","funder_award_id":"P01CA040042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000983089.pdf","grobid_xml":"https://content.openalex.org/works/W2000983089.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W23999710","https://openalex.org/W1019447032","https://openalex.org/W1481629090","https://openalex.org/W1489145497","https://openalex.org/W1549544590","https://openalex.org/W1551296854","https://openalex.org/W1586543565","https://openalex.org/W1590827448","https://openalex.org/W1813709997","https://openalex.org/W1838164920","https://openalex.org/W1912221395","https://openalex.org/W1926397135","https://openalex.org/W1930335657","https://openalex.org/W1969979508","https://openalex.org/W1988600555","https://openalex.org/W1993679701","https://openalex.org/W2003434949","https://openalex.org/W2005529016","https://openalex.org/W2006892275","https://openalex.org/W2007745785","https://openalex.org/W2012116939","https://openalex.org/W2016568386","https://openalex.org/W2018289835","https://openalex.org/W2020257412","https://openalex.org/W2023313751","https://openalex.org/W2024134178","https://openalex.org/W2025018535","https://openalex.org/W2029231027","https://openalex.org/W2032359283","https://openalex.org/W2036145275","https://openalex.org/W2041534105","https://openalex.org/W2043117244","https://openalex.org/W2047851489","https://openalex.org/W2052561585","https://openalex.org/W2053799953","https://openalex.org/W2054325863","https://openalex.org/W2056104802","https://openalex.org/W2056770464","https://openalex.org/W2058860422","https://openalex.org/W2058885870","https://openalex.org/W2062576661","https://openalex.org/W2067083395","https://openalex.org/W2067405360","https://openalex.org/W2073052622","https://openalex.org/W2081950746","https://openalex.org/W2084162464","https://openalex.org/W2085154580","https://openalex.org/W2100837269","https://openalex.org/W2108674983","https://openalex.org/W2109594922","https://openalex.org/W2112093320","https://openalex.org/W2124890374","https://openalex.org/W2139666587","https://openalex.org/W2142714350","https://openalex.org/W2148849095","https://openalex.org/W2152133730","https://openalex.org/W2156411608","https://openalex.org/W2161683013","https://openalex.org/W2162075350","https://openalex.org/W2162700552","https://openalex.org/W2395438838","https://openalex.org/W2399838398","https://openalex.org/W2436156910","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1991015390","https://openalex.org/W2144020592","https://openalex.org/W1543594980","https://openalex.org/W1988664861","https://openalex.org/W1926397135","https://openalex.org/W1981462495","https://openalex.org/W2014280822","https://openalex.org/W2063259786","https://openalex.org/W2081135891","https://openalex.org/W2156451315"],"abstract_inverted_index":{"The":[0,36],"integrin":[1,63],"family":[2],"of":[3,34,62,71,75,85,103,122],"heterodimeric":[4],"cell":[5],"surface":[6],"receptors":[7],"play":[8],"critical":[9],"roles":[10],"in":[11,51,77,100],"multiple":[12],"biological":[13],"processes":[14],"by":[15,136,155],"mediating":[16],"cellular":[17,52,156,160],"adhesion":[18,120],"to":[19,115],"the":[20,72,90,101,118],"extracellular":[21],"matrix":[22],"(ECM).":[23],"Adhesion":[24,38,110],"triggers":[25],"intracellular":[26],"signaling":[27,64],"cascades,":[28],"including":[29],"tyrosine":[30,45],"phosphorylation":[31],"and":[32],"elevation":[33],"[Ca2+]i.":[35],"Focal":[37,109],"Kinase":[39],"(FAK":[40],"or":[41,151,158],"pp125FAK),":[42],"a":[43,56,60,82,147],"protein":[44],"kinase":[46],"that":[47,130],"colocalizes":[48],"with":[49],"integrins":[50],"focal":[53,119],"adhesions,":[54],"is":[55,152],"prime":[57],"candidate":[58],"for":[59,94],"mediator":[61],"events.":[65],"Here":[66],"we":[67,79],"report":[68],"an":[69,104],"analysis":[70,128],"domain":[73],"structure":[74],"FAK":[76],"which":[78],"have":[80],"identified":[81],"contiguous":[83],"stretch":[84],"159":[86],"amino":[87],"acids":[88],"within":[89],"COOH":[91],"terminus":[92],"essential":[93],"correct":[95],"subcellular":[96],"localization.":[97],"When":[98],"placed":[99],"context":[102],"unrelated":[105],"cytosolic":[106],"protein,":[107],"this":[108,123,127],"Targeting":[111],"(FAT)":[112],"sequence":[113],"functions":[114],"efficiently":[116],"mediate":[117],"localization":[121],"fusion":[124],"protein.":[125],"Furthermore,":[126],"suggests":[129],"pp125FAK":[131],"cannot":[132],"be":[133,141],"activated":[134],"oncogenically":[135],"mutation.":[137],"This":[138],"result":[139],"could":[140],"explained":[142],"if":[143],"pp125FK":[144],"either":[145],"exhibits":[146],"narrow":[148],"substrate":[149],"specificity":[150],"diametrically":[153],"opposed":[154],"phosphatases":[157],"other":[159],"processes.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}