{"id":"https://openalex.org/W2000979605","doi":"https://doi.org/10.1016/j.biopsych.2006.01.016","title":"Eszopiclone Co-Administered With Fluoxetine in Patients With Insomnia Coexisting With Major Depressive Disorder","display_name":"Eszopiclone Co-Administered With Fluoxetine in Patients With Insomnia Coexisting With Major Depressive Disorder","publication_year":2006,"publication_date":"2006-04-05","ids":{"openalex":"https://openalex.org/W2000979605","doi":"https://doi.org/10.1016/j.biopsych.2006.01.016","mag":"2000979605","pmid":"https://pubmed.ncbi.nlm.nih.gov/16581036"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2006.01.016","doi":"https://doi.org/10.1016/j.biopsych.2006.01.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2006.01.016","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084024326","display_name":"Maurizio Fava M. D","orcid":"https://orcid.org/0000-0002-4635-0458","observed_orcids":["https://orcid.org/0000-0002-4635-0458"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maurizio Fava","raw_affiliation_strings":["Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA. mfava@partners.org","Depression Clinical and Research Program, Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA. mfava@partners.org","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Depression Clinical and Research Program, Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087471581","display_name":"William Vaughn McCall","orcid":"https://orcid.org/0000-0001-5035-7858","observed_orcids":["https://orcid.org/0000-0001-5035-7858"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Vaughn McCall","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Wake Forest University, Winston-Salem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Wake Forest University, Winston-Salem","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042168269","display_name":"Andrew D. Krystal","orcid":"https://orcid.org/0000-0002-6702-781X","observed_orcids":["https://orcid.org/0000-0002-6702-781X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Krystal","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053410578","display_name":"Thomas C. Wessel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Wessel","raw_affiliation_strings":["Sepracor, Marlborough, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sepracor, Marlborough, Massachusetts","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109123098","display_name":"Robert Rubens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Rubens","raw_affiliation_strings":["Sepracor, Marlborough, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sepracor, Marlborough, Massachusetts","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058012375","display_name":"Judy Caron","orcid":"https://orcid.org/0000-0002-3878-2971","observed_orcids":["https://orcid.org/0000-0002-3878-2971"]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy Caron","raw_affiliation_strings":["Sepracor, Marlborough, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sepracor, Marlborough, Massachusetts","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106083321","display_name":"David A. Amato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Amato","raw_affiliation_strings":["Sepracor, Marlborough, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sepracor, Marlborough, Massachusetts","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011832419","display_name":"Thomas G. Roth","orcid":"https://orcid.org/0000-0001-8309-4134","observed_orcids":["https://orcid.org/0000-0001-8309-4134"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Roth","raw_affiliation_strings":["Henry Ford Hospital Sleep Center, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital Sleep Center, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5084024326"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":5489,"currency":"USD","value_usd":5489},"apc_paid":null,"fwci":29.4963,"has_fulltext":false,"cited_by_count":479,"citation_normalized_percentile":{"value":0.99904464,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"59","issue":"11","first_page":"1052","last_page":"1060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eszopiclone","display_name":"eszopiclone","score":1.0},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":1.0},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.972000002861023},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.5199999809265137},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.7129999995231628},{"id":"https://openalex.org/keywords/co-therapy","display_name":"co-therapy","score":0.6060000061988831},{"id":"https://openalex.org/keywords/daytime-functioning","display_name":"daytime functioning","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.7662886381149292},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.7039048075675964},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6564782857894897},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5150167942047119},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4548441171646118},{"id":"https://openalex.org/C2910795097","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Chronic insomnia","level":4,"score":0.44585514068603516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4068615436553955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1900501549243927},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.18732675909996033},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.05097532272338867},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.043174952268600464},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012650","descriptor_name":"Self Disclosure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopsych.2006.01.016","doi":"https://doi.org/10.1016/j.biopsych.2006.01.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2006.01.016","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:16581036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16581036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W591815358","https://openalex.org/W1521227715","https://openalex.org/W1555810878","https://openalex.org/W1564547297","https://openalex.org/W1574826837","https://openalex.org/W1597415827","https://openalex.org/W1668771230","https://openalex.org/W1930767620","https://openalex.org/W1970151346","https://openalex.org/W1975683065","https://openalex.org/W1977894152","https://openalex.org/W1980789635","https://openalex.org/W1984796397","https://openalex.org/W1991156723","https://openalex.org/W2043913146","https://openalex.org/W2046970666","https://openalex.org/W2055309882","https://openalex.org/W2056454671","https://openalex.org/W2066580767","https://openalex.org/W2074772116","https://openalex.org/W2080503978","https://openalex.org/W2094300830","https://openalex.org/W2099661804","https://openalex.org/W2114613490","https://openalex.org/W2117415335","https://openalex.org/W2136100428","https://openalex.org/W2144749508","https://openalex.org/W2170435962","https://openalex.org/W2279856945","https://openalex.org/W2316767766","https://openalex.org/W2409501828","https://openalex.org/W2414400730","https://openalex.org/W4205385607","https://openalex.org/W4238924031"],"related_works":["https://openalex.org/W2013542392","https://openalex.org/W2029771261","https://openalex.org/W27463876","https://openalex.org/W2416477247","https://openalex.org/W2523521870","https://openalex.org/W2025525296","https://openalex.org/W1436801937","https://openalex.org/W2032147697","https://openalex.org/W2295551135","https://openalex.org/W1984461780"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":38},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
