{"id":"https://openalex.org/W2000978117","doi":"https://doi.org/10.1021/jf970980f","title":"Effect of Thermal Protectants on the Stability of Bovine Milk Immunoglobulin G","display_name":"Effect of Thermal Protectants on the Stability of Bovine Milk Immunoglobulin G","publication_year":1998,"publication_date":"1998-08-14","ids":{"openalex":"https://openalex.org/W2000978117","doi":"https://doi.org/10.1021/jf970980f","mag":"2000978117"},"language":"en","primary_location":{"id":"doi:10.1021/jf970980f","doi":"https://doi.org/10.1021/jf970980f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf970980f","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052831018","display_name":"Chao\u2010Cheng Chen","orcid":"https://orcid.org/0000-0003-2685-6766","observed_orcids":["https://orcid.org/0000-0003-2685-6766"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chao-Cheng Chen","raw_affiliation_strings":["Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan, and Department of Food Health, Chia-Nan College of Pharmacy, Tainan 717, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan, and Department of Food Health, Chia-Nan College of Pharmacy, Tainan 717, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103449490","display_name":"Hung\u2010Min Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Min Chang","raw_affiliation_strings":["Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan, and Department of Food Health, Chia-Nan College of Pharmacy, Tainan 717, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan, and Department of Food Health, Chia-Nan College of Pharmacy, Tainan 717, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7071,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.67188934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"9","first_page":"3570","last_page":"3576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.20389999449253082,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ph-stability","display_name":"pH stability","score":0.8029999732971191},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/colostrum","display_name":"colostrum","score":0.843999981880188},{"id":"https://openalex.org/keywords/whey","display_name":"whey","score":0.9879999756813049},{"id":"https://openalex.org/keywords/homogenization","display_name":"homogenization","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ultrasonic-treatment","display_name":"ultrasonic treatment","score":0.972000002861023},{"id":"https://openalex.org/keywords/fructose","display_name":"fructose","score":0.5350000262260437},{"id":"https://openalex.org/keywords/maltose","display_name":"maltose","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":0.902999997138977},{"id":"https://openalex.org/keywords/lactose","display_name":"lactose","score":0.8339999914169312},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.6940000057220459},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8149999976158142},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycerol","display_name":"glycerol","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sorbitol","display_name":"sorbitol","score":0.8809999823570251},{"id":"https://openalex.org/keywords/polyols","display_name":"sugar alcohols","score":0.7910000085830688},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7698923945426941},{"id":"https://openalex.org/C2779073587","wikidata":"https://www.wikidata.org/wiki/Q192746","display_name":"Colostrum","level":3,"score":0.7563638687133789},{"id":"https://openalex.org/C2776779347","wikidata":"https://www.wikidata.org/wiki/Q245280","display_name":"Sorbitol","level":2,"score":0.6432275176048279},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.6271489858627319},{"id":"https://openalex.org/C59061564","wikidata":"https://www.wikidata.org/wiki/Q7783071","display_name":"Thermal stability","level":2,"score":0.615436851978302},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.5311834812164307},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.527219295501709},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.5195884704589844},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.46624937653541565},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36638957262039185},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3563075363636017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32776936888694763},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10983341932296753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09787356853485107},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jf970980f","doi":"https://doi.org/10.1021/jf970980f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf970980f","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W598731303","https://openalex.org/W1534376087","https://openalex.org/W1986190327","https://openalex.org/W1991469452","https://openalex.org/W1991653424","https://openalex.org/W2005901472","https://openalex.org/W2013566359","https://openalex.org/W2022901251","https://openalex.org/W2027918911","https://openalex.org/W2034649269","https://openalex.org/W2043389165","https://openalex.org/W2045529455","https://openalex.org/W2051844042","https://openalex.org/W2095540105","https://openalex.org/W2118864235","https://openalex.org/W2128635872","https://openalex.org/W2280151827","https://openalex.org/W2327463745","https://openalex.org/W2416325180","https://openalex.org/W2557347386","https://openalex.org/W4232094777","https://openalex.org/W4233218824","https://openalex.org/W4237775605"],"related_works":["https://openalex.org/W2151755845","https://openalex.org/W2027918911","https://openalex.org/W2380326616","https://openalex.org/W2379180560","https://openalex.org/W2525382791","https://openalex.org/W2094064916","https://openalex.org/W2392720517","https://openalex.org/W2366881100","https://openalex.org/W2369326757","https://openalex.org/W831608665"],"abstract_inverted_index":{"pH":[0,42,113],"stability,":[1,3],"thermal":[2,236,245],"and":[4,9,35,96,131,138,176,199,222,226],"the":[5,13,55,58,80,124,165,216,235],"effect":[6],"of":[7,15,82,153,195],"homogenization":[8],"ultrasonic":[10],"treatment":[11],"on":[12,57],"stability":[14],"bovine":[16],"milk":[17,240],"immunoglobulin":[18,241],"G":[19,242],"(IgG)":[20],"in":[21,54,69,72,79,105,129,143,184,190,204],"model":[22],"systems":[23],"was":[24,30,61,101,115],"studied.":[25],"Separated":[26],"IgG":[27,53,87,99,104,127,142,167,183,192,203,218,233],"(0.02":[28],"mg/mL)":[29],"found":[31,62,134],"to":[32,37,63,135,169,182,187,202],"be":[33,64,136],"unstable":[34],"susceptible":[36],"denaturation":[38],"when":[39,74,103],"incubated":[40],"at":[41,49,77,117,146,207],"<4":[43],"or":[44,46,71,156],">10":[45],"thermally":[47,75],"treated":[48,76],"temperature":[50],">75":[51],"\u00b0C.":[52,84],"colostrum,":[56],"other":[59],"hand,":[60],"much":[65],"more":[66,90],"stable":[67],"than":[68],"whey":[70,130],"PBS":[73,106,144,185,205],"temperatures":[78],"range":[81],"75\u2212100":[83],"The":[85],"residual":[86,126,166,191,217],"content":[88,100,168,219],"reduced":[89],"sharply":[91],"with":[92],"increasing":[93],"heating":[94],"times,":[95],"almost":[97],"no":[98],"detected":[102],"(0.15":[107],"M":[108,110],"NaCl/0.01":[109],"phosphate":[111],"buffer,":[112],"7.0)":[114],"heated":[116,145,206],"95":[118,147,208],"\u00b0C":[119,148,209],"for":[120,149,210],"15":[121,150,211],"s,":[122,151],"whereas":[123],"corresponding":[125],"contents":[128],"colostrum":[132],"were":[133],"42":[137],"59%,":[139],"respectively.":[140,224],"For":[141],"addition":[152,180],"5%":[154],"fructose":[155],"maltose":[157],"displayed":[158],"most":[159],"remarkable":[160],"protection":[161],"effects":[162],"by":[163,172,220],"raising":[164],"31%,":[170],"followed":[171],"sucrose,":[173],"lactose,":[174],"glucose,":[175],"galactose.":[177],"However,":[178],"extravagant":[179],"(>30%)":[181],"led":[186],"a":[188],"decline":[189],"content.":[193],"Addition":[194],"0.4%":[196],"glutamic":[197],"acid":[198],"2%":[200],"glycine":[201],"s":[212],"also":[213],"remarkably":[214],"improved":[215],"13.5":[221],"26.7%,":[223],"Glycerol":[225],"sugar":[227,249],"alcohol,":[228],"such":[229],"as":[230],"sorbitol,":[231],"stabilized":[232],"during":[234],"treatment.":[237],"Keywords:":[238],"Bovine":[239],"(IgG);":[243],"stability;":[244],"protectant;":[246],"amino":[247],"acid;":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}