{"id":"https://openalex.org/W2000973947","doi":"https://doi.org/10.1016/s0003-2697(03)00297-5","title":"Aptamer-based biosensor arrays for detection and quantification of biological macromolecules","display_name":"Aptamer-based biosensor arrays for detection and quantification of biological macromolecules","publication_year":2003,"publication_date":"2003-06-30","ids":{"openalex":"https://openalex.org/W2000973947","doi":"https://doi.org/10.1016/s0003-2697(03)00297-5","mag":"2000973947","pmid":"https://pubmed.ncbi.nlm.nih.gov/12871718"},"language":"en","primary_location":{"id":"doi:10.1016/s0003-2697(03)00297-5","doi":"https://doi.org/10.1016/s0003-2697(03)00297-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-2697(03)00297-5","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041941478","display_name":"Thomas G. McCauley","orcid":"https://orcid.org/0009-0002-6261-9119","observed_orcids":["https://orcid.org/0009-0002-6261-9119"]},"institutions":[{"id":"https://openalex.org/I4210103301","display_name":"Archemix (United States)","ror":"https://ror.org/00v8tzb98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103301"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas G McCauley","raw_affiliation_strings":["Archemix Corp., Cambridge, MA 02139-1520, USA. mccauley@archemix.com","Archemix Corp., Cambridge, MA 02139-1520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Archemix Corp., Cambridge, MA 02139-1520, USA. mccauley@archemix.com","institution_ids":["https://openalex.org/I4210103301"]},{"raw_affiliation_string":"Archemix Corp., Cambridge, MA 02139-1520, USA","institution_ids":["https://openalex.org/I4210103301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053129511","display_name":"Nobuko Hamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103301","display_name":"Archemix (United States)","ror":"https://ror.org/00v8tzb98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103301"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nobuko Hamaguchi","raw_affiliation_strings":["Archemix Corp., 1 Hampshire Street, Cambridge, MA 02139-1520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Archemix Corp., 1 Hampshire Street, Cambridge, MA 02139-1520, USA","institution_ids":["https://openalex.org/I4210103301"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016449217","display_name":"Martin J. Stanton","orcid":"https://orcid.org/0000-0003-3788-0374","observed_orcids":["https://orcid.org/0000-0003-3788-0374"]},"institutions":[{"id":"https://openalex.org/I4210103301","display_name":"Archemix (United States)","ror":"https://ror.org/00v8tzb98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103301"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Stanton","raw_affiliation_strings":["Archemix Corp., 1 Hampshire Street, Cambridge, MA 02139-1520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Archemix Corp., 1 Hampshire Street, Cambridge, MA 02139-1520, USA","institution_ids":["https://openalex.org/I4210103301"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041941478"],"corresponding_institution_ids":["https://openalex.org/I4210103301"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":4.9319,"has_fulltext":false,"cited_by_count":268,"citation_normalized_percentile":{"value":0.96837956,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"319","issue":"2","first_page":"244","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":0.8989999890327454},{"id":"https://openalex.org/keywords/biosensor-arrays","display_name":"biosensor arrays","score":0.9110000133514404},{"id":"https://openalex.org/keywords/multiplex-protein-detection","display_name":"multiplex protein detection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fluorescence-anisotropy","display_name":"fluorescence anisotropy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/protein-quantification","display_name":"protein quantification","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tumor-associated-proteins","display_name":"tumor-associated proteins","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":1.0},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9246464967727661},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.8187179565429688},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6676053404808044},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.6343285441398621},{"id":"https://openalex.org/C111357860","wikidata":"https://www.wikidata.org/wiki/Q903807","display_name":"Fluorescence anisotropy","level":3,"score":0.5715122818946838},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5684600472450256},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5110081434249878},{"id":"https://openalex.org/C2910703447","wikidata":"https://www.wikidata.org/wiki/Q494918","display_name":"Protein Array Analysis","level":5,"score":0.4599446654319763},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.4594931900501251},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44464272260665894},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3568081855773926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3375903069972992},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3308638036251068},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.297146201133728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26293185353279114},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.20758813619613647},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12092140316963196},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11930227279663086},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007168","descriptor_name":"IMP Dehydrogenase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007168","descriptor_name":"IMP Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0003-2697(03)00297-5","doi":"https://doi.org/10.1016/s0003-2697(03)00297-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-2697(03)00297-5","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},{"id":"pmid:12871718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12871718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1487586028","https://openalex.org/W1578213890","https://openalex.org/W1964858690","https://openalex.org/W1982601427","https://openalex.org/W1994947678","https://openalex.org/W2018223808","https://openalex.org/W2034269086","https://openalex.org/W2037509330","https://openalex.org/W2056285082","https://openalex.org/W2056511887","https://openalex.org/W2056789539","https://openalex.org/W2074933374","https://openalex.org/W2087146563","https://openalex.org/W2093531978","https://openalex.org/W2104525153","https://openalex.org/W2118696808","https://openalex.org/W2122992861","https://openalex.org/W2129995310","https://openalex.org/W2134556593","https://openalex.org/W2165011536","https://openalex.org/W2288750238","https://openalex.org/W2471274090","https://openalex.org/W4211027922","https://openalex.org/W4388387232"],"related_works":["https://openalex.org/W2018483173","https://openalex.org/W2050939006","https://openalex.org/W1972309130","https://openalex.org/W2188082121","https://openalex.org/W2739804257","https://openalex.org/W2058120890","https://openalex.org/W2096804006","https://openalex.org/W2783924924","https://openalex.org/W7153245888","https://openalex.org/W2291479460"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}