{"id":"https://openalex.org/W2000970155","doi":"https://doi.org/10.1007/bf00496432","title":"Increased secretion of fibronectin and collagen by progeria (Hutchinson-Gilford) fibroblasts","display_name":"Increased secretion of fibronectin and collagen by progeria (Hutchinson-Gilford) fibroblasts","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W2000970155","doi":"https://doi.org/10.1007/bf00496432","mag":"2000970155","pmid":"https://pubmed.ncbi.nlm.nih.gov/3396601"},"language":"en","primary_location":{"id":"doi:10.1007/bf00496432","doi":"https://doi.org/10.1007/bf00496432","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00496432","pdf_url":null,"source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024053290","display_name":"Fran\u00e7ois\u2010Xavier Maquart","orcid":"https://orcid.org/0000-0001-7814-0343","observed_orcids":["https://orcid.org/0000-0001-7814-0343"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. X. Maquart","raw_affiliation_strings":["Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049635748","display_name":"Georges Bellon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Bellon","raw_affiliation_strings":["Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060274898","display_name":"Philippe Gillery","orcid":"https://orcid.org/0000-0002-1100-8759","observed_orcids":["https://orcid.org/0000-0002-1100-8759"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Gillery","raw_affiliation_strings":["Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045559458","display_name":"Borel Jp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. P. Borel","raw_affiliation_strings":["Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, 51 rue Cognacq Jay, F-51095, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Biochimie (CNRS UA 610), Facult\u00e9 de M\u00e9decine, Reims C\u00e9dex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107422811","display_name":"Bruno Labeille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Labeille","raw_affiliation_strings":["Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, F-80030, Amiens Cedex, France","Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, Amiens Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, F-80030, Amiens Cedex, France","institution_ids":["https://openalex.org/I4210096553"]},{"raw_affiliation_string":"Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, Amiens Cedex, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086270377","display_name":"B Risbourg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Risbourg","raw_affiliation_strings":["Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, F-80030, Amiens Cedex, France","Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, Amiens Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, F-80030, Amiens Cedex, France","institution_ids":["https://openalex.org/I4210096553"]},{"raw_affiliation_string":"Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, Amiens Cedex, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110018361","display_name":"J P Denoeux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. P. Denoeux","raw_affiliation_strings":["Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, F-80030, Amiens Cedex, France","Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, Amiens Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, F-80030, Amiens Cedex, France","institution_ids":["https://openalex.org/I4210096553"]},{"raw_affiliation_string":"Services de Dermatologie et de P\u00e9diatrie II, Centre Hospitalier Universitaire, Amiens Cedex, France","institution_ids":["https://openalex.org/I4210096553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":null,"fwci":0.446,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.56098331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"147","issue":"4","first_page":"442","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hutchinson-gilford-progeria-syndrome","display_name":"Hutchinson-Gilford progeria syndrome","score":0.9100000262260437},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.9150000214576721},{"id":"https://openalex.org/keywords/extracellular-matrix-secretion","display_name":"extracellular matrix secretion","score":0.9359999895095825},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9340000152587891},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2778465436","wikidata":"https://www.wikidata.org/wiki/Q213098","display_name":"Progeria","level":3,"score":0.9376487731933594},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.866980791091919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7725931406021118},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6305885314941406},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35316455364227295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32937151193618774},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32739147543907166},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.26420724391937256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21257373690605164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10091564059257507},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05177539587020874}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011371","descriptor_name":"Progeria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00496432","doi":"https://doi.org/10.1007/bf00496432","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00496432","pdf_url":null,"source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:3396601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3396601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pediatrics","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W998175253","https://openalex.org/W1552718139","https://openalex.org/W1987203822","https://openalex.org/W1991454255","https://openalex.org/W2018289835","https://openalex.org/W2100837269","https://openalex.org/W2229775693","https://openalex.org/W2415037212"],"related_works":["https://openalex.org/W2051304298","https://openalex.org/W1914644234","https://openalex.org/W4412515874","https://openalex.org/W2028998065","https://openalex.org/W7168464804","https://openalex.org/W3149479276","https://openalex.org/W3187943734","https://openalex.org/W7099293335","https://openalex.org/W2465062141","https://openalex.org/W1999489194"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}