{"id":"https://openalex.org/W2000969676","doi":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","title":"High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1\u2010independent DSB repair pathway","display_name":"High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1\u2010independent DSB repair pathway","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2000969676","doi":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","mag":"2000969676","pmid":"https://pubmed.ncbi.nlm.nih.gov/10526232"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2443.1999.00273.x","doi":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2443.1999.00273.x","source":{"id":"https://openalex.org/S48908450","display_name":"Genes to Cells","issn_l":"1356-9597","issn":["1356-9597","1365-2443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2443.1999.00273.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075651833","display_name":"Douglas K. Bishop","orcid":"https://orcid.org/0000-0001-5061-8085","observed_orcids":["https://orcid.org/0000-0001-5061-8085"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas K. Bishop","raw_affiliation_strings":["Department of Radiation and Cellular Oncology, University of Chicago, Chicago IL 60637, USA. dbishop@midway.uchicago.edu","Department of Radiation and Cellular Oncology University of Chicago, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology, University of Chicago, Chicago IL 60637, USA. dbishop@midway.uchicago.edu","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation and Cellular Oncology University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070287780","display_name":"Yuri Nikolsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri Nikolski","raw_affiliation_strings":["Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022397132","display_name":"June Oshiro","orcid":"https://orcid.org/0000-0003-1134-5023","observed_orcids":["https://orcid.org/0000-0003-1134-5023"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June Oshiro","raw_affiliation_strings":["Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046003287","display_name":"Jason Chon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Chon","raw_affiliation_strings":["Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033775542","display_name":"Miki Shinohara","orcid":"https://orcid.org/0000-0002-7413-8235","observed_orcids":["https://orcid.org/0000-0002-7413-8235"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miki Shinohara","raw_affiliation_strings":["Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100329949","display_name":"Xi Chen","orcid":"https://orcid.org/0000-0002-5166-0872","observed_orcids":["https://orcid.org/0000-0002-5166-0872"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Chen","raw_affiliation_strings":["Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology and Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation & Cellular Oncology and Department of Molecular Genetics & Cell Biology, University of Chicago, Chicago, IL 60637 USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075651833"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.9577,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.70820325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"4","issue":"8","first_page":"425","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meiotic-recombination","display_name":"meiotic recombination","score":0.7670000195503235},{"id":"https://openalex.org/keywords/dmc1","display_name":"DMC1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/rec114","display_name":"REC114","score":0.9789999723434448},{"id":"https://openalex.org/keywords/rad54","display_name":"Rad54","score":1.0},{"id":"https://openalex.org/keywords/red1","display_name":"Red1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/meiotic-prophase-arrest","display_name":"meiotic prophase arrest","score":0.8169999718666077},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8019999861717224},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.7310000061988831},{"id":"https://openalex.org/keywords/sister-chromatid-recombination","display_name":"sister chromatid recombination","score":0.8080000281333923},{"id":"https://openalex.org/keywords/meiosis","display_name":"meiosis","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7730932235717773},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6074594259262085},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.5706150531768799},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.5534374117851257},{"id":"https://openalex.org/C45413362","wikidata":"https://www.wikidata.org/wiki/Q6013254","display_name":"Prophase","level":4,"score":0.4842959940433502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4766203463077545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3488481044769287},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27004799246788025}],"mesh":[{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045522","descriptor_name":"Recombinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2443.1999.00273.x","doi":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2443.1999.00273.x","source":{"id":"https://openalex.org/S48908450","display_name":"Genes to Cells","issn_l":"1356-9597","issn":["1356-9597","1365-2443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to Cells","raw_type":"journal-article"},{"id":"pmid:10526232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10526232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to cells : devoted to molecular & cellular mechanisms","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-2443.1999.00273.x","doi":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2443.1999.00273.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2443.1999.00273.x","source":{"id":"https://openalex.org/S48908450","display_name":"Genes to Cells","issn_l":"1356-9597","issn":["1356-9597","1365-2443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes to Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3337894397","display_name":"Meiotic Interactions of the RecA Homologue Dmc1","funder_award_id":"R01GM050936","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000969676.pdf","grobid_xml":"https://content.openalex.org/works/W2000969676.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W100422003","https://openalex.org/W1485797794","https://openalex.org/W1676891985","https://openalex.org/W1694178424","https://openalex.org/W1847047834","https://openalex.org/W1851483641","https://openalex.org/W1864762190","https://openalex.org/W1899118230","https://openalex.org/W1901764626","https://openalex.org/W1936192069","https://openalex.org/W1958548845","https://openalex.org/W1966608028","https://openalex.org/W1968096672","https://openalex.org/W1970604907","https://openalex.org/W1973687790","https://openalex.org/W1973782344","https://openalex.org/W1975749117","https://openalex.org/W1982084965","https://openalex.org/W1987350343","https://openalex.org/W1987868273","https://openalex.org/W1989788017","https://openalex.org/W2014765530","https://openalex.org/W2023216619","https://openalex.org/W2028084970","https://openalex.org/W2029611498","https://openalex.org/W2040015408","https://openalex.org/W2041929141","https://openalex.org/W2046058790","https://openalex.org/W2046296698","https://openalex.org/W2047106949","https://openalex.org/W2048684608","https://openalex.org/W2052521064","https://openalex.org/W2056750443","https://openalex.org/W2073407368","https://openalex.org/W2083397831","https://openalex.org/W2083854515","https://openalex.org/W2084496260","https://openalex.org/W2089804282","https://openalex.org/W2091512138","https://openalex.org/W2091536217","https://openalex.org/W2094414993","https://openalex.org/W2096679672","https://openalex.org/W2102684624","https://openalex.org/W2107448248","https://openalex.org/W2110129679","https://openalex.org/W2111059688","https://openalex.org/W2114531852","https://openalex.org/W2118834362","https://openalex.org/W2131238674","https://openalex.org/W2138872641","https://openalex.org/W2144190798","https://openalex.org/W2144668992","https://openalex.org/W2149148071","https://openalex.org/W2156465196","https://openalex.org/W2164558029","https://openalex.org/W2164682707","https://openalex.org/W2165545825","https://openalex.org/W2169656163","https://openalex.org/W2171885622","https://openalex.org/W2183518601","https://openalex.org/W2201392717","https://openalex.org/W2203076878","https://openalex.org/W2256478821","https://openalex.org/W7100502720"],"related_works":["https://openalex.org/W2047106949","https://openalex.org/W4293253423","https://openalex.org/W1973687790","https://openalex.org/W6911147130","https://openalex.org/W7024336047","https://openalex.org/W2020184155","https://openalex.org/W2990321891","https://openalex.org/W2136536970","https://openalex.org/W7167236321","https://openalex.org/W1958548845"],"abstract_inverted_index":{"BACKGROUND:":[0],"DMC1,":[1],"the":[2,48,58,68,129,173],"meiosis-specific":[3],"eukaryotic":[4],"homologue":[5],"of":[6,13,74,84,94,105,110,121,128,132,161,170,186,194,199,208,215,226],"bacterial":[7],"recA,":[8],"is":[9,96,101,165,221],"required":[10,140,166],"for":[11,141,159,167],"completion":[12],"meiotic":[14,49,142,189],"recombination":[15,29,69,79,175,220,232],"and":[16,32,118,150],"cell":[17],"cycle":[18],"progression":[19],"past":[20],"prophase.":[21,36],"In":[22],"a":[23,133,138,202,227],"dmc1":[24,54,88,113,181],"mutant,":[25],"double":[26,75,182],"strand":[27,76],"break":[28,77],"intermediates":[30],"accumulate":[31],"cells":[33],"arrest":[34,50,65,190],"in":[35,136,148,179],"We":[37],"isolated":[38,60],"genes":[39,59],"which,":[40],"when":[41,98],"present":[42],"at":[43],"high":[44,91],"copy":[45,92,108,197],"numbers,":[46],"suppress":[47,64,112],"phenotype":[51],"conferred":[52],"by":[53,66,87,103,172,191,210],"mutations.":[55],"RESULTS:":[56],"Among":[57],"were":[61],"two":[62],"which":[63],"altering":[67],"process.":[70],"REC114":[71,95,187],"suppresses":[72,188],"formation":[73,120,193],"(DSB)":[78],"intermediates.":[80],"The":[81,213],"low":[82],"viability":[83],"spores":[85,123],"produced":[86],"mutants":[89],"carrying":[90],"numbers":[93,109,198],"rescued":[97],"reductional":[99,125],"segregation":[100],"bypassed":[102],"mutation":[104,135],"spo13.":[106],"High":[107,196],"RAD54":[111,149,200,216],"arrest,":[114],"promote":[115,218],"DSB":[116],"repair,":[117],"allow":[119],"viable":[122],"following":[124],"segregation.":[126],"Analysis":[127],"combined":[130],"effects":[131],"null":[134,146],"RED1,":[137],"gene":[139],"chromosome":[143],"structure,":[144],"with":[145],"mutations":[147],"DMC1":[151],"shows":[152],"that":[153,177,205,229],"RAD54,":[154],"while":[155],"not":[156],"normally":[157,230],"important":[158],"repair":[160,169,207],"DSBs":[162,209],"during":[163],"meiosis,":[164],"efficient":[168],"breaks":[171],"intersister":[174],"pathway":[176],"operates":[178],"red1":[180],"mutants.":[183],"CONCLUSIONS:":[184],"Over-expression":[185],"preventing":[192],"DSBs.":[195],"activate":[201],"DMC1-independent":[203,219],"mechanism":[204],"promotes":[206,231],"homology-mediated":[211],"recombination.":[212],"ability":[214],"to":[217,223],"proposed":[222],"involve":[224],"suppression":[225],"constraint":[228],"between":[233],"homologous":[234],"chromatids":[235],"rather":[236],"than":[237],"sisters.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}