{"id":"https://openalex.org/W2000966600","doi":"https://doi.org/10.1006/jmbi.1996.0243","title":"From Structure to Sequence and Back Again","display_name":"From Structure to Sequence and Back Again","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W2000966600","doi":"https://doi.org/10.1006/jmbi.1996.0243","mag":"2000966600","pmid":"https://pubmed.ncbi.nlm.nih.gov/8613988"},"language":"en","primary_location":{"id":"doi:10.1006/jmbi.1996.0243","doi":"https://doi.org/10.1006/jmbi.1996.0243","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jmbi.1996.0243","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1006/jmbi.1996.0243","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056201449","display_name":"David A. Hinds","orcid":"https://orcid.org/0000-0002-4911-803X","observed_orcids":["https://orcid.org/0000-0002-4911-803X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Hinds","raw_affiliation_strings":["Department of Structural Biology, Stanford University School of Medicine, CA 94305, USA","Beckman Laboratories for Structural Biology, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Stanford University School of Medicine, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Beckman Laboratories for Structural Biology, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019080704","display_name":"Michael Levitt","orcid":"https://orcid.org/0000-0002-8414-7397","observed_orcids":["https://orcid.org/0000-0002-8414-7397"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Levitt","raw_affiliation_strings":["Beckman Laboratories for Structural Biology, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laboratories for Structural Biology, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019080704"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":{"value":4730,"currency":"USD","value_usd":4730},"fwci":1.2622,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.78660583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"258","issue":"1","first_page":"201","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-sequence-design","display_name":"protein sequence design","score":0.8450000286102295},{"id":"https://openalex.org/keywords/lattice-model","display_name":"lattice model","score":0.7120000123977661},{"id":"https://openalex.org/keywords/conformational-search","display_name":"conformational search","score":0.8339999914169312},{"id":"https://openalex.org/keywords/energy-minimization","display_name":"energy minimization","score":0.593999981880188},{"id":"https://openalex.org/keywords/amino-acid-diversity","display_name":"amino acid diversity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/sequence-structure-relationship","display_name":"sequence-structure relationship","score":0.5139999985694885},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.722611129283905},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.6637438535690308},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5093485116958618},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.47578752040863037},{"id":"https://openalex.org/C186370098","wikidata":"https://www.wikidata.org/wiki/Q442787","display_name":"Energy (signal processing)","level":2,"score":0.46191075444221497},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.45951521396636963},{"id":"https://openalex.org/C105168689","wikidata":"https://www.wikidata.org/wiki/Q901969","display_name":"Globular protein","level":2,"score":0.4477244019508362},{"id":"https://openalex.org/C2781204021","wikidata":"https://www.wikidata.org/wiki/Q6497091","display_name":"Lattice (music)","level":2,"score":0.43421316146850586},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4320484399795532},{"id":"https://openalex.org/C105082737","wikidata":"https://www.wikidata.org/wiki/Q7452470","display_name":"Sequence logo","level":5,"score":0.4133804738521576},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.397803395986557},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.384334534406662},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3385164737701416},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3353625535964966},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.29782742261886597},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2921742796897888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26463571190834045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24667015671730042},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2103995978832245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14425429701805115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1223234236240387},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10582107305526733},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1006/jmbi.1996.0243","doi":"https://doi.org/10.1006/jmbi.1996.0243","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jmbi.1996.0243","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:8613988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8613988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.41.8252","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.41.8252","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://csb.stanford.edu/levitt/Hinds_JMB96_seq_opt.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1006/jmbi.1996.0243","doi":"https://doi.org/10.1006/jmbi.1996.0243","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jmbi.1996.0243","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2042812721","display_name":null,"funder_award_id":"GM41455-07","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1569560802","https://openalex.org/W1574312817","https://openalex.org/W1968827368","https://openalex.org/W1975017420","https://openalex.org/W1980471666","https://openalex.org/W1984527736","https://openalex.org/W1997550234","https://openalex.org/W1999669514","https://openalex.org/W2023829406","https://openalex.org/W2034984854","https://openalex.org/W2038117444","https://openalex.org/W2040390777","https://openalex.org/W2040594319","https://openalex.org/W2041149980","https://openalex.org/W2058187117","https://openalex.org/W2062175659","https://openalex.org/W2072843928","https://openalex.org/W2089563755","https://openalex.org/W2092409871","https://openalex.org/W2139415631"],"related_works":["https://openalex.org/W7099850584","https://openalex.org/W2009186593","https://openalex.org/W7097676561","https://openalex.org/W7000157576","https://openalex.org/W2071256770","https://openalex.org/W2154515666","https://openalex.org/W1991099809","https://openalex.org/W2057939225","https://openalex.org/W2085497102","https://openalex.org/W3044593510"],"abstract_inverted_index":{"With":[0],"a":[1,35,61],"simple":[2],"lattice":[3],"model":[4,70],"and":[5],"sequence":[6,63],"design":[7,11,25,90,101],"algorithm,":[8],"we":[9],"can":[10],"sequences":[12,50,103],"to":[13,32,52,99],"fit":[14],"arbitrary":[15],"compact":[16],"globular":[17],"structures.":[18],"We":[19,72],"judged":[20],"the":[21,24,42,74,78,86,89],"success":[22,87],"of":[23,76,80,88],"algorithm":[26],"by":[27],"performing":[28],"exhaustive":[29],"conformational":[30],"searches":[31],"determine":[33],"if":[34],"designed":[36],"sequence's":[37],"lowest":[38,68],"energy":[39,69],"conformation":[40],"matched":[41],"target":[43],"for":[44,57,66],"which":[45],"it":[46],"was":[47,93],"designed.":[48],"Designed":[49],"tend":[51],"be":[53],"much":[54],"better":[55],"optimized":[56,65],"their":[58],"targets":[59],"than":[60],"natural":[62],"is":[64],"its":[67],"conformation.":[71],"examined":[73],"effect":[75],"varying":[77],"number":[79],"available":[81],"amino":[82,106],"acid":[83,107],"types":[84],"on":[85],"method.":[91],"It":[92],"more":[94],"difficult":[95],"but":[96],"not":[97],"impossible":[98],"successfully":[100],"discriminating":[102],"using":[104],"fewer":[105],"types.":[108]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
