{"id":"https://openalex.org/W2000962149","doi":"https://doi.org/10.1021/ja0559707","title":"Priming Type II Polyketide Synthases via a Type II Nonribosomal Peptide Synthetase Mechanism","display_name":"Priming Type II Polyketide Synthases via a Type II Nonribosomal Peptide Synthetase Mechanism","publication_year":2006,"publication_date":"2006-01-11","ids":{"openalex":"https://openalex.org/W2000962149","doi":"https://doi.org/10.1021/ja0559707","mag":"2000962149","pmid":"https://pubmed.ncbi.nlm.nih.gov/16448095","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2531066"},"language":"en","primary_location":{"id":"doi:10.1021/ja0559707","doi":"https://doi.org/10.1021/ja0559707","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja0559707","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2531066/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091309318","display_name":"Miho Izumikawa","orcid":"https://orcid.org/0000-0001-5277-5260","observed_orcids":["https://orcid.org/0000-0001-5277-5260"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I150209017","display_name":"Scripps Institution of Oceanography","ror":"https://ror.org/04v7hvq31","country_code":"US","type":"facility","lineage":["https://openalex.org/I150209017","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miho Izumikawa","raw_affiliation_strings":["College of Pharmacy, University of Arizona, Tucson, Arizona 85721, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Arizona, Tucson, Arizona 85721, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I150209017","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100851780","display_name":"Qian Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I150209017","display_name":"Scripps Institution of Oceanography","ror":"https://ror.org/04v7hvq31","country_code":"US","type":"facility","lineage":["https://openalex.org/I150209017","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Cheng","raw_affiliation_strings":["College of Pharmacy, University of Arizona, Tucson, Arizona 85721, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Arizona, Tucson, Arizona 85721, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I150209017","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042160264","display_name":"Bradley S. Moore","orcid":"https://orcid.org/0000-0002-4652-1253","observed_orcids":["https://orcid.org/0000-0002-4652-1253"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I150209017","display_name":"Scripps Institution of Oceanography","ror":"https://ror.org/04v7hvq31","country_code":"US","type":"facility","lineage":["https://openalex.org/I150209017","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley S. Moore","raw_affiliation_strings":["College of Pharmacy, University of Arizona, Tucson, Arizona 85721, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Arizona, Tucson, Arizona 85721, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I150209017","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.9835,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.93632838,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"128","issue":"5","first_page":"1428","last_page":"1429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-ii-polyketide-synthase","display_name":"type II polyketide synthase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/enterocins","display_name":"enterocins","score":0.7049999833106995},{"id":"https://openalex.org/keywords/actinorhodin","display_name":"actinorhodin","score":1.0},{"id":"https://openalex.org/keywords/acyl-carrier-protein","display_name":"acyl carrier protein","score":0.8080000281333923},{"id":"https://openalex.org/keywords/aryl-transfer","display_name":"aryl transfer","score":0.5379999876022339},{"id":"https://openalex.org/keywords/aromatic-polyketides","display_name":"aromatic polyketides","score":0.8669999837875366},{"id":"https://openalex.org/keywords/biocatalysis","display_name":"biocatalysis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/polyketide-biosynthesis","display_name":"polyketide biosynthesis","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.9329158067703247},{"id":"https://openalex.org/C2776668381","wikidata":"https://www.wikidata.org/wiki/Q4676996","display_name":"Actinorhodin","level":5,"score":0.8862506151199341},{"id":"https://openalex.org/C2777379556","wikidata":"https://www.wikidata.org/wiki/Q1443801","display_name":"Nonribosomal peptide","level":4,"score":0.8655415773391724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8572993874549866},{"id":"https://openalex.org/C2780786045","wikidata":"https://www.wikidata.org/wiki/Q1087229","display_name":"Acyl carrier protein","level":4,"score":0.6743297576904297},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5605763792991638},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5343934893608093},{"id":"https://openalex.org/C2777763344","wikidata":"https://www.wikidata.org/wiki/Q4369963","display_name":"Polyketide synthase","level":5,"score":0.5001144409179688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45355963706970215},{"id":"https://openalex.org/C168831097","wikidata":"https://www.wikidata.org/wiki/Q413248","display_name":"Depsipeptide","level":2,"score":0.41430237889289856},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.298103928565979},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25040799379348755}],"mesh":[{"descriptor_ui":"D000095622","descriptor_name":"Benzoisochromanequinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000213","descriptor_name":"Acyl Carrier Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000213","descriptor_name":"Acyl Carrier Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003065","descriptor_name":"Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003065","descriptor_name":"Coenzyme A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009279","descriptor_name":"Naphthacenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009279","descriptor_name":"Naphthacenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ja0559707","doi":"https://doi.org/10.1021/ja0559707","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja0559707","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:16448095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16448095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2531066","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2531066/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2531066","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2531066/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1576805608","display_name":"Biosynthesis of Marine Polyketide Antibiotics","funder_award_id":"R56AI047818","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1745768855","display_name":null,"funder_award_id":"AI-47818","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8301920961","display_name":"Biosynthesis of Marine Polyketide Antibiotics","funder_award_id":"R01AI047818","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1496011245","https://openalex.org/W1896660825","https://openalex.org/W1923254660","https://openalex.org/W1971662732","https://openalex.org/W1990197243","https://openalex.org/W2013718446","https://openalex.org/W2020983997","https://openalex.org/W2026654673","https://openalex.org/W2026697320","https://openalex.org/W2035481174","https://openalex.org/W2042055680","https://openalex.org/W2060819997","https://openalex.org/W2069588559","https://openalex.org/W2082234458","https://openalex.org/W2107713423","https://openalex.org/W2119495364","https://openalex.org/W2161570550","https://openalex.org/W2164170982"],"related_works":["https://openalex.org/W2040133963","https://openalex.org/W118322166","https://openalex.org/W2046666269","https://openalex.org/W2031541469","https://openalex.org/W2070644078","https://openalex.org/W2058183250","https://openalex.org/W7095988350","https://openalex.org/W2979899722","https://openalex.org/W2007617042","https://openalex.org/W2325767697"],"abstract_inverted_index":{"Benzoic":[0],"acid":[1,43],"priming":[2],"of":[3,40,63,88],"the":[4,27,35,41,45,64,69,73,86],"enterocin":[5,71],"and":[6,34,57,72],"actinorhodin":[7,75],"type":[8,20],"II":[9,21],"polyketide":[10,96],"synthase":[11],"complexes":[12],"was":[13,81],"accomplished":[14],"in":[15],"vitro":[16],"via":[17],"an":[18],"unprecedented":[19],"nonribosomal":[22],"peptide":[23],"synthetase-like":[24],"mechanism":[25],"involving":[26],"benzoate:acyl":[28],"carrier":[29],"protein":[30,58],"(ACP)":[31],"ligase":[32],"EncN":[33],"ACP":[36,46],"EncC.":[37],"The":[38],"transfer":[39],"aryl":[42,66],"to":[44,68],"is":[47],"ATP-dependent,":[48],"yet":[49],"coenzyme":[50],"A-independent,":[51],"as":[52],"characterized":[53],"with":[54],"radiolabeled":[55],"substrates":[56],"mass":[59],"spectrometry.":[60],"Subsequent":[61],"transport":[62],"ACP-bound":[65],"group":[67],"native":[70],"aberrant":[74],"ketosynthase":[76],"chain":[77],"length":[78],"factor":[79],"heterodimers":[80],"further":[82],"demonstrated,":[83],"thereby":[84],"demonstrating":[85],"potential":[87],"this":[89],"biocatalyst":[90],"for":[91],"engineering":[92],"diverse":[93],"aryl-primed":[94],"aromatic":[95],"agents.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
