{"id":"https://openalex.org/W2000951915","doi":"https://doi.org/10.1001/archotol.132.4.409","title":"Fine-Mapping Loss of Gene Architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP Genes in Head and Neck Squamous Cell Carcinoma","display_name":"Fine-Mapping Loss of Gene Architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP Genes in Head and Neck Squamous Cell Carcinoma","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2000951915","doi":"https://doi.org/10.1001/archotol.132.4.409","mag":"2000951915","pmid":"https://pubmed.ncbi.nlm.nih.gov/16618910"},"language":"en","primary_location":{"id":"doi:10.1001/archotol.132.4.409","doi":"https://doi.org/10.1001/archotol.132.4.409","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.132.4.409","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology\u2013Head &amp; Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109917162","display_name":"Maria J. Worsham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria J. Worsham","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery and Research Division, Henry Ford Hospital, Detroit, MI 48202, USA. mworsha1@hfhs.org","Department of Otolaryngology-Head and Neck Surgery and Research Division, Henry Ford Hospital, Detroit, MI 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery and Research Division, Henry Ford Hospital, Detroit, MI 48202, USA. mworsha1@hfhs.org","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery and Research Division, Henry Ford Hospital, Detroit, MI 48202, USA","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071265031","display_name":"Kang Mei Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kang Mei Chen","raw_affiliation_strings":["Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048912807","display_name":"Nivedita Tiwari","orcid":"https://orcid.org/0000-0002-2663-7582","observed_orcids":["https://orcid.org/0000-0002-2663-7582"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nivedita Tiwari","raw_affiliation_strings":["Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049211733","display_name":"Gerard Pals","orcid":"https://orcid.org/0000-0003-4091-7115","observed_orcids":["https://orcid.org/0000-0003-4091-7115"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerard Pals","raw_affiliation_strings":["Vrije Universiteit Amsterdam ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam ,","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103513258","display_name":"Jan P. Schouten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129008","display_name":"MRC Holland (Netherlands)","ror":"https://ror.org/02wcat891","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210129008"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan P. Schouten","raw_affiliation_strings":["MRC Holland B.V"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Holland B.V","institution_ids":["https://openalex.org/I4210129008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112720141","display_name":"Seema Niphadkar Sethi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema Sethi","raw_affiliation_strings":["Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086953145","display_name":"Michael S. Benninger","orcid":"https://orcid.org/0000-0003-1908-397X","observed_orcids":["https://orcid.org/0000-0003-1908-397X"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Benninger","raw_affiliation_strings":["Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1296,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.96652086,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"132","issue":"4","first_page":"409","last_page":"409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/9p21-loss","display_name":"9p21 loss","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.890999972820282},{"id":"https://openalex.org/keywords/mtap","display_name":"MTAP","score":0.9340000152587891},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.824999988079071},{"id":"https://openalex.org/keywords/p14arf","display_name":"p14ARF","score":0.9890000224113464},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/fine-mapping","display_name":"fine mapping","score":0.6660000085830688},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7350000143051147},{"id":"https://openalex.org/keywords/recurrent-or-metastatic-cancer","display_name":"recurrent or metastatic cancer","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2776300330","wikidata":"https://www.wikidata.org/wiki/Q17860505","display_name":"CDKN2B","level":4,"score":0.8806551694869995},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.7810807228088379},{"id":"https://openalex.org/C2776750431","wikidata":"https://www.wikidata.org/wiki/Q7117832","display_name":"p14arf","level":5,"score":0.7613165378570557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7154550552368164},{"id":"https://openalex.org/C120599132","wikidata":"https://www.wikidata.org/wiki/Q602889","display_name":"Multiplex ligation-dependent probe amplification","level":4,"score":0.6838657855987549},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5961424708366394},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.468661904335022},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4288233518600464},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.387807160615921},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.37046027183532715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2672548294067383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1894315779209137},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.17999544739723206},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.14932870864868164}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025803","descriptor_name":"Tumor Suppressor Protein p14ARF","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archotol.132.4.409","doi":"https://doi.org/10.1001/archotol.132.4.409","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.132.4.409","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology\u2013Head &amp; Neck Surgery","raw_type":"journal-article"},{"id":"pmid:16618910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16618910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of otolaryngology--head & neck surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4924414594","display_name":"MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC","funder_award_id":"R01DE015990","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1481437079","https://openalex.org/W1574614093","https://openalex.org/W1605264554","https://openalex.org/W1686733339","https://openalex.org/W1823272702","https://openalex.org/W1912789001","https://openalex.org/W1944467204","https://openalex.org/W1966510680","https://openalex.org/W1973812603","https://openalex.org/W1989586626","https://openalex.org/W2003907692","https://openalex.org/W2028605039","https://openalex.org/W2029080338","https://openalex.org/W2029506693","https://openalex.org/W2037073011","https://openalex.org/W2044761859","https://openalex.org/W2067795112","https://openalex.org/W2071039438","https://openalex.org/W2074854597","https://openalex.org/W2082221644","https://openalex.org/W2095410376","https://openalex.org/W2105428856","https://openalex.org/W2111209219","https://openalex.org/W2111420633","https://openalex.org/W2113926943","https://openalex.org/W2124968502","https://openalex.org/W2133282020","https://openalex.org/W2138386102","https://openalex.org/W2140507460","https://openalex.org/W2144208437","https://openalex.org/W2149624899","https://openalex.org/W2164686711","https://openalex.org/W2166944576","https://openalex.org/W2168633685","https://openalex.org/W2171815789","https://openalex.org/W2260028313","https://openalex.org/W2318659033","https://openalex.org/W2332501724","https://openalex.org/W2415703915","https://openalex.org/W2474195763"],"related_works":["https://openalex.org/W2147109892","https://openalex.org/W2036966657","https://openalex.org/W1964794425","https://openalex.org/W2292769011","https://openalex.org/W2116114777","https://openalex.org/W2316978458","https://openalex.org/W2038710682","https://openalex.org/W1985028821","https://openalex.org/W2531830858","https://openalex.org/W2054153896"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"identify":[2],"the":[3,6,36,45,59,74,96,146,197,214,226,232,248],"extent":[4],"and":[5,14,28,38,54,58,88,92,123,134,166,174,178,238,245,266],"smallest":[7,227],"region":[8,43,75,228],"of":[9,18,35,76,154,185,196,200,229,241,250,258],"loss":[10,78,169,195,230,240],"for":[11,82,85,90,109,172,190,217,256],"CDKN2B(INK4b),":[12,83,242],"CDKN2A(ARF,INK4a),":[13],"MTAP.":[15],"Homozygous":[16,168],"deletions":[17],"human":[19],"chromosome":[20],"9p21":[21,77],"occur":[22],"frequently":[23],"in":[24,31,145,176,204,231,247,264],"malignant":[25],"cell":[26,33,128],"lines":[27,129,149],"are":[29],"common":[30],"squamous":[32],"carcinoma":[34],"head":[37,265],"neck":[39,267],"(HNSCC).":[40],"This":[41],"complex":[42],"encodes":[44],"tumor":[46],"suppressor":[47],"genes":[48],"cyclin-dependent":[49],"kinase":[50],"2B":[51],"(CDKN2B)":[52],"(p15(INK4b))":[53],"CDKN2A":[55,110],"(p14(ARF),":[56],"p16(INK4a))":[57],"housekeeping":[60],"gene":[61],"methylthioadenosine":[62],"phosphorylase":[63],"(MTAP).":[64],"DESIGN:":[65],"A":[66],"targeted":[67],"probe":[68,99],"panel":[69],"designed":[70],"to":[71,162],"finely":[72],"map":[73],"comprised":[79],"3":[80,89],"probes":[81],"7":[84],"CDKN2A(ARF,":[86,155,233,243],"INK4a),":[87,244],"MTAP":[91,201,246],"was":[93,170,202],"interrogated":[94],"using":[95,113],"multiplex":[97],"ligation-dependent":[98],"amplification":[100],"assay":[101],"(MLPA).":[102],"The":[103,236],"MLPA":[104,210],"genomic":[105],"copy":[106],"number":[107],"alterations":[108,207],"were":[111,130,211],"validated":[112,212],"real-time":[114],"polymerase":[115],"chain":[116],"reaction.":[117],"SUBJECTS:":[118],"Six":[119],"HNSCC":[120,252],"primary":[121],"(A)":[122],"recurrent":[124],"or":[125],"metastatic":[126],"(B)":[127],"examined:":[131],"UMSCC-11A/11B,":[132],"UMSCC-17A/17B,":[133],"UMSCC-81A/81B.":[135],"RESULTS:":[136],"Cell":[137,148,180],"line":[138,181],"UMSCC-11B":[139],"retained":[140],"all":[141,186],"9p":[142,187],"loci":[143,188],"tested":[144],"region.":[147],"UMSCC-17A/B":[150],"indicated":[151,171,183],"homozygous":[152],"deletion":[153],"INK4a)":[156,234],"starting":[157],"at":[158,213],"p16(INK4)":[159],"exon":[160,191,222],"1alpha":[161,192,223],"include":[163],"exons":[164],"2":[165],"3.":[167],"CDKN2B(INK4b)":[173],"CDKN2A(ARF,INK4a)":[175],"UMSCC-11A,":[177],"UMSCC-81A.":[179],"UMSCC-81B":[182],"retention":[184],"except":[189],"(p16(INK4a)).":[193],"Selective":[194],"3'":[198],"end":[199],"observed":[203],"UMSCC-11A.":[205],"Genomic":[206],"by":[208],"fine-mapping":[209],"DNA":[215],"level":[216],"CDKN2A.":[218],"CONCLUSIONS:":[219],"We":[220],"identified":[221],"(p16(INK4a))":[224],"as":[225,261],"gene.":[235],"frequency":[237],"precise":[239],"prognosis":[249],"9p21-deleted":[251],"may":[253],"provide":[254],"impetus":[255],"use":[257],"these":[259],"targets":[260],"therapeutic":[262],"biomarkers":[263],"cancer.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
