{"id":"https://openalex.org/W2000942655","doi":"https://doi.org/10.1055/s-2005-872853","title":"Coagulation Factor XIII Reduces Postoperative Bleeding After Coronary Surgery with Extracorporeal Circulation","display_name":"Coagulation Factor XIII Reduces Postoperative Bleeding After Coronary Surgery with Extracorporeal Circulation","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2000942655","doi":"https://doi.org/10.1055/s-2005-872853","mag":"2000942655","pmid":"https://pubmed.ncbi.nlm.nih.gov/16485185"},"language":"en","primary_location":{"id":"doi:10.1055/s-2005-872853","doi":"https://doi.org/10.1055/s-2005-872853","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2005-872853","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082291191","display_name":"Oliver L G\u00f6dje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. G\u00f6dje","raw_affiliation_strings":["Department of Cardiac Surgery, University Hospital, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, University Hospital, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013385206","display_name":"U Gallmeier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Gallmeier","raw_affiliation_strings":["Department of Cardiac Surgery, University Hospital, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, University Hospital, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080397094","display_name":"M. Schelian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Schelian","raw_affiliation_strings":["Department of Cardiac Surgery, University Hospital, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, University Hospital, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103177498","display_name":"Martin Gr\u00fcnewald","orcid":"https://orcid.org/0000-0003-0936-4305","observed_orcids":["https://orcid.org/0000-0003-0936-4305"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Gr\u00fcnewald","raw_affiliation_strings":["Department of Clinical Hemostaseology, University Hospital, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hemostaseology, University Hospital, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080655148","display_name":"Helmut Mair","orcid":"https://orcid.org/0000-0002-5946-0891","observed_orcids":["https://orcid.org/0000-0002-5946-0891"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Mair","raw_affiliation_strings":["Ludwig-Maximilians-University, Klinikum Gro\u00dfhadern, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig-Maximilians-University, Klinikum Gro\u00dfhadern, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6547,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.93143003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"54","issue":"1","first_page":"26","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coagulation-factor-xiii","display_name":"coagulation factor XIII","score":0.9580000042915344},{"id":"https://openalex.org/keywords/postoperative-bleeding","display_name":"postoperative bleeding","score":0.9350000023841858},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8859999775886536},{"id":"https://openalex.org/keywords/protamine","display_name":"protamine","score":0.5370000004768372},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.6980000138282776},{"id":"https://openalex.org/keywords/coagulation-monitoring","display_name":"coagulation monitoring","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9031675457954407},{"id":"https://openalex.org/C2994232697","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal circulation","level":2,"score":0.7463665008544922},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6569318771362305},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.6206905245780945},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5756187438964844},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5203651785850525},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.5185428261756897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29926079511642456},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001026","descriptor_name":"Coronary Artery Bypass","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005176","descriptor_name":"Factor XIII","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005176","descriptor_name":"Factor XIII","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005176","descriptor_name":"Factor XIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019106","descriptor_name":"Postoperative Hemorrhage","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019106","descriptor_name":"Postoperative Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2005-872853","doi":"https://doi.org/10.1055/s-2005-872853","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2005-872853","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},{"id":"pmid:16485185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16485185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and cardiovascular surgeon","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072702070","https://openalex.org/W2138768842","https://openalex.org/W2028913279","https://openalex.org/W7162468565","https://openalex.org/W2068460773","https://openalex.org/W2042893845","https://openalex.org/W1979249554","https://openalex.org/W2410352985","https://openalex.org/W2059698635","https://openalex.org/W2733750117"],"abstract_inverted_index":{"BACKGROUND:":[0],"One":[1],"cause":[2],"of":[3,15,53,60,64,83,86,91,113,178,198,227,241,261],"diffuse":[4],"bleeding":[5],"after":[6,58,108,244],"cardiac":[7],"operations":[8],"may":[9],"be":[10,214],"a":[11,36,47],"low":[12],"plasma":[13,84,253,262],"concentration":[14],"coagulation":[16,23,30],"Factor":[17,87,98,117,190,231,267],"XIII,":[18],"which":[19],"is":[20,25,249,264],"essential":[21],"for":[22],"but":[24],"not":[26,75,166],"covered":[27],"by":[28],"standard":[29],"monitoring.":[31],"PATIENTS":[32],"AND":[33],"METHODS:":[34],"In":[35,95],"prospective,":[37],"randomized,":[38],"double":[39],"blinded":[40],"study,":[41],"2500":[42,133,154],"units,":[43,45,131],"1250":[44,130],"and":[46,67,132,137,157,202,238],"placebo":[48,161],"were":[49,74,140],"administered":[50],"in":[51,127,152,159,175,217],"groups":[52,97,195],"25":[54],"patients":[55,184],"each,":[56],"immediately":[57],"administration":[59,90,112,233,248],"protamine.":[61],"Postoperative":[62,147],"amount":[63,177,226],"blood":[65,68,148,179,209,228,236,242],"loss":[66,149,210,237],"transfusion":[69,243],"was":[70,150,165,170,211,224],"recorded.":[71],"RESULTS:":[72],"Patients":[73],"statistically":[76,141],"different":[77],"with":[78,196],"respect":[79],"to":[80,105,120,186,213],"the":[81,92,114,128,153,160,176,218,225,239,257],"course":[82],"levels":[85,197,254,263],"XIII":[88,99,118,191,232,268],"until":[89],"study":[93,115],"drug.":[94],"all":[96,183],"fell":[100],"from":[101],"preoperative":[102],"normal":[103,258],"values":[104,107],"subnormal":[106],"extracorporeal":[109],"circulation.":[110],"After":[111,181],"drug,":[116],"increased":[119],"71":[121],"%,":[122,124,207],"85":[123],"103":[125],"%":[126,201,221],"placebo,":[129],"units":[134,155],"group,":[135,162],"respectively,":[136],"these":[138],"differences":[139],"significant":[142,173],"(":[143],"p":[144],"<":[145,199,219],"0.05).":[146],"lowest":[151],"group":[156,222],"highest":[158],"however":[163,247],"this":[164],"significantly":[167,215],"different.":[168],"There":[169],"also":[171],"no":[172],"difference":[174],"transfusion.":[180],"differentiating":[182],"according":[185],"their":[187],"post":[188],"medication":[189],"level":[192],"into":[193],"two":[194],"70":[200,206,220],">":[203],"or":[204],"=":[205],"postoperative":[208,235],"found":[212],"higher":[216],"as":[223],"transfusions.":[229],"CONCLUSIONS:":[230],"reduces":[234],"extent":[240],"coronary":[245],"surgery,":[246],"only":[250],"helpful":[251],"if":[252],"are":[255],"below":[256],"value.":[259],"Measurement":[260],"recommended":[265],"before":[266],"substitution.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}