{"id":"https://openalex.org/W2000942098","doi":"https://doi.org/10.1292/jvms.62.179","title":"Plasma Concentrations of an Angiotensin-Converting Enzyme Inhibitor, Benazepril, and Its Active Metabolite, Benazeprilat, after Repeated Administrations of Benazepril in Dogs with Experimental Kidney Impairment.","display_name":"Plasma Concentrations of an Angiotensin-Converting Enzyme Inhibitor, Benazepril, and Its Active Metabolite, Benazeprilat, after Repeated Administrations of Benazepril in Dogs with Experimental Kidney Impairment.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2000942098","doi":"https://doi.org/10.1292/jvms.62.179","mag":"2000942098","pmid":"https://pubmed.ncbi.nlm.nih.gov/10720188"},"language":"en","primary_location":{"id":"doi:10.1292/jvms.62.179","doi":"https://doi.org/10.1292/jvms.62.179","is_oa":true,"landing_page_url":"https://doi.org/10.1292/jvms.62.179","pdf_url":"https://www.jstage.jst.go.jp/article/jvms/62/2/62_2_179/_pdf","source":{"id":"https://openalex.org/S40103090","display_name":"Journal of Veterinary Medical Science","issn_l":"0916-7250","issn":["0916-7250","1347-7439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313482","host_organization_name":"Japanese Society of Veterinary Science","host_organization_lineage":["https://openalex.org/P4310313482"],"host_organization_lineage_names":["Japanese Society of Veterinary Science"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jstage.jst.go.jp/article/jvms/62/2/62_2_179/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000699188","display_name":"Hitoshi KITAGAWA","orcid":"https://orcid.org/0000-0002-1724-164X","observed_orcids":["https://orcid.org/0000-0002-1724-164X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi KITAGAWA","raw_affiliation_strings":["Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032495694","display_name":"Tokuhiro EGUCHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tokuhiro EGUCHI","raw_affiliation_strings":["Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108288497","display_name":"Katsuya KITOH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuya KITOH","raw_affiliation_strings":["Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113676959","display_name":"Yasunori OHBA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunori OHBA","raw_affiliation_strings":["Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102898728","display_name":"Masahiro Kondo","orcid":"https://orcid.org/0000-0002-2274-7872","observed_orcids":["https://orcid.org/0000-0002-2274-7872"]},"institutions":[{"id":"https://openalex.org/I4210105804","display_name":"Novartis (Japan)","ror":"https://ror.org/01k1ftz35","country_code":"JP","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210105804"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro KONDO","raw_affiliation_strings":["Novartis Agro K. K., 2 Hamamatsu-cho, Minato-ku, Tokyo 105-6134, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Agro K. K., 2 Hamamatsu-cho, Minato-ku, Tokyo 105-6134, Japan","institution_ids":["https://openalex.org/I4210105804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masakazu NAKANO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105804","display_name":"Novartis (Japan)","ror":"https://ror.org/01k1ftz35","country_code":"JP","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210105804"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu NAKANO","raw_affiliation_strings":["Novartis Agro K. K., 2 Hamamatsu-cho, Minato-ku, Tokyo 105-6134, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Agro K. K., 2 Hamamatsu-cho, Minato-ku, Tokyo 105-6134, Japan","institution_ids":["https://openalex.org/I4210105804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052951508","display_name":"Yoshihide SASAKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihide SASAKI","raw_affiliation_strings":["Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Internal Medicine, Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2417,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58352002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"62","issue":"2","first_page":"179","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benazepril","display_name":"benazepril","score":0.9879999756813049},{"id":"https://openalex.org/keywords/benazeprilat","display_name":"benazeprilat","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.75},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5460000038146973},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7350000143051147},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.597000002861023},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/renal-plasma-flow","display_name":"renal plasma flow","score":0.6420000195503235},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasma-ace-activity","display_name":"plasma ACE activity","score":0.6809999942779541},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.8450000286102295},{"id":"https://openalex.org/keywords/drug-excretion","display_name":"drug excretion","score":0.40400001406669617},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.4880000054836273},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.3009999990463257}],"concepts":[{"id":"https://openalex.org/C2777363265","wikidata":"https://www.wikidata.org/wiki/Q592802","display_name":"Benazepril","level":3,"score":0.9051898717880249},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6882785558700562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6703442335128784},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6533507108688354},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6296253800392151},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.5362979769706726},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4990830421447754},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.454872727394104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4456958770751953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4219772219657898},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.29875385761260986},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.12511387467384338}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1292/jvms.62.179","doi":"https://doi.org/10.1292/jvms.62.179","is_oa":true,"landing_page_url":"https://doi.org/10.1292/jvms.62.179","pdf_url":"https://www.jstage.jst.go.jp/article/jvms/62/2/62_2_179/_pdf","source":{"id":"https://openalex.org/S40103090","display_name":"Journal of Veterinary Medical Science","issn_l":"0916-7250","issn":["0916-7250","1347-7439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313482","host_organization_name":"Japanese Society of Veterinary Science","host_organization_lineage":["https://openalex.org/P4310313482"],"host_organization_lineage_names":["Japanese Society of Veterinary Science"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Medical Science","raw_type":"journal-article"},{"id":"pmid:10720188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10720188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of veterinary medical science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1292/jvms.62.179","doi":"https://doi.org/10.1292/jvms.62.179","is_oa":true,"landing_page_url":"https://doi.org/10.1292/jvms.62.179","pdf_url":"https://www.jstage.jst.go.jp/article/jvms/62/2/62_2_179/_pdf","source":{"id":"https://openalex.org/S40103090","display_name":"Journal of Veterinary Medical Science","issn_l":"0916-7250","issn":["0916-7250","1347-7439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313482","host_organization_name":"Japanese Society of Veterinary Science","host_organization_lineage":["https://openalex.org/P4310313482"],"host_organization_lineage_names":["Japanese Society of Veterinary Science"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000942098.pdf","grobid_xml":"https://content.openalex.org/works/W2000942098.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1757280844","https://openalex.org/W1893127269","https://openalex.org/W1970886804","https://openalex.org/W1975393563","https://openalex.org/W2004158297","https://openalex.org/W2008713440","https://openalex.org/W2013103240","https://openalex.org/W2021889873","https://openalex.org/W2031829160","https://openalex.org/W2032587118","https://openalex.org/W2057693502","https://openalex.org/W2070569497","https://openalex.org/W2085147947","https://openalex.org/W2090611890","https://openalex.org/W2108434580","https://openalex.org/W2312400976","https://openalex.org/W2409562890","https://openalex.org/W2464068974","https://openalex.org/W4255286222"],"related_works":["https://openalex.org/W2331928206","https://openalex.org/W2233985678","https://openalex.org/W1757280844","https://openalex.org/W2052821578","https://openalex.org/W2032587118","https://openalex.org/W1991389439","https://openalex.org/W1970282405","https://openalex.org/W2399314636","https://openalex.org/W7000034849","https://openalex.org/W2018464672"],"abstract_inverted_index":{"In":[0,169,208],"order":[1],"to":[2,123,140,178,182,292,311],"examine":[3],"the":[4,28,52,156,162,170,197,202,209,218,226,240,258,266,298,317,323],"safety":[5],"of":[6,26,31,49,51,99,144,228,252,274,287,300],"an":[7],"angiotensin-converting":[8],"enzyme":[9],"(ACE)":[10],"inhibitor":[11],"in":[12,35,161,217,246,272,285,307],"dogs":[13,36,57,73,104,273,286,308],"with":[14,37,225,309],"impaired":[15],"renal":[16,38,54,132,313],"excretion":[17],"route,":[18],"benazepril":[19,60],"was":[20,319],"administered":[21,59],"orally,":[22],"and":[23,47,70,93,119,127,131,135,142,165,190,204,230,242,268,297,325],"plasma":[24,116,133,174,198,213,253],"concentrations":[25,121,176,200,215,255],"benazeprilat,":[27],"active":[29],"metabolite":[30],"benazepril,":[32],"were":[33,58,192,231,262],"determined":[34,256],"mass":[39],"reduction":[40],"(1/4th":[41,95],"kidney)":[42],"created":[43],"by":[44],"right-side":[45],"nephrectomy":[46],"ligation":[48],"branches":[50],"left":[53],"arteries.":[55],"Five":[56],"orally":[61],"at":[62],"a":[63,113,294],"given":[64],"dose":[65,78,248,276],"(0.5":[66],"mg/kg":[67,80,164,167,172,211],"body":[68,81],"weight)":[69,82],"4":[71],"other":[72],"received":[74,105],"20":[75,180],"times":[76],"that":[77],"(10":[79],"once":[83],"daily":[84],"for":[85],"15":[86],"consecutive":[87],"days":[88,227],"before":[89],"(intact":[90],"kidney":[91,96,100,158,206,244,270],"period)":[92,97],"after":[94,187,282],"creation":[98],"impairment.":[101],"Six":[102],"control":[103],"surgical":[106],"treatment,":[107],"but":[108,221],"no":[109,193],"drug.":[110],"After":[111],"creating":[112],"1/4th":[114,157,205,243,269],"kidney,":[115],"urea":[117],"nitrogen":[118],"creatinine":[120],"increased":[122,177],"approximately":[124,179],"30":[125],"mg/dl":[126],"2.0":[128],"mg/dl,":[129],"respectively,":[130],"flow":[134],"glomerular":[136],"filtration":[137],"rate":[138],"decreased":[139,281],"37%":[141],"30%":[143],"pre-treatment":[145],"values,":[146],"respectively.":[147],"However,":[148],"these":[149],"parameters":[150],"did":[151,222],"not":[152,223,232,263,304],"change":[153],"significantly":[154,233],"during":[155,201],"period":[159],"both":[160,288,321],"0.5":[163,171],"10":[166,210],"groups.":[168,289],"group,":[173,212],"benazeprilat":[175,199,214,254],"ng/ml":[181,184],"340":[183],"2":[185],"hr":[186],"each":[188,236],"administration,":[189,229],"there":[191],"significant":[194],"differences":[195],"between":[196,239,265],"intact":[203,241,267],"periods.":[207],"varied":[216],"individual":[219],"dog,":[220],"increase":[224],"different":[234,264],"on":[235,257],"administration":[237,260,284],"day":[238,261],"periods":[245,271],"either":[247,275],"group.":[249,277],"The":[250],"AUCs(0-24)":[251],"15th":[259],"Plasma":[278],"ACE":[279],"activities":[280],"drug":[283,318],"Benazepril":[290],"seemed":[291],"have":[293],"high":[295],"safety,":[296],"adjustment":[299],"dosage":[301],"regimen":[302],"might":[303],"be":[305],"needed":[306],"mild":[310],"moderate":[312],"function":[314],"impairment":[315],"because":[316],"excreted":[320],"from":[322],"kidneys":[324],"liver.":[326]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
