{"id":"https://openalex.org/W2000940741","doi":"https://doi.org/10.1242/dev.00860","title":"Embryos at the core of life","display_name":"Embryos at the core of life","publication_year":2003,"publication_date":"2003-10-22","ids":{"openalex":"https://openalex.org/W2000940741","doi":"https://doi.org/10.1242/dev.00860","mag":"2000940741"},"language":"en","primary_location":{"id":"doi:10.1242/dev.00860","doi":"https://doi.org/10.1242/dev.00860","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.00860","pdf_url":"https://journals.biologists.com/dev/article-pdf/130/23/5564/1498073/5564.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.biologists.com/dev/article-pdf/130/23/5564/1498073/5564.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051041983","display_name":"Diego Rasskin\u2010Gutman","orcid":"https://orcid.org/0000-0002-0290-720X","observed_orcids":["https://orcid.org/0000-0002-0290-720X"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego Rasskin-Gutman","raw_affiliation_strings":["The Salk Institute for Biological Studies, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute for Biological Studies, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050690657","display_name":"Juan Carlos Izpis\u00faa Belmonte","orcid":"https://orcid.org/0000-0003-0557-8875","observed_orcids":["https://orcid.org/0000-0003-0557-8875"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Carlos Izpisu\u0301a Belmonte","raw_affiliation_strings":["The Salk Institute for Biological Studies, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute for Biological Studies, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08789974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"23","first_page":"5564","last_page":"5566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/developmental-biology","display_name":"developmental biology","score":0.7590000033378601},{"id":"https://openalex.org/keywords/embryology","display_name":"embryology","score":0.6299999952316284},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.8730000257492065},{"id":"https://openalex.org/keywords/development-and-evolution","display_name":"development and evolution","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.6919999718666077},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.5910000205039978},{"id":"https://openalex.org/keywords/pattern-formation","display_name":"pattern formation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mesoderm-patterning","display_name":"mesoderm patterning","score":0.8650000095367432},{"id":"https://openalex.org/keywords/endoderm","display_name":"endoderm","score":0.4659999907016754},{"id":"https://openalex.org/keywords/ectoderm","display_name":"ectoderm","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.37400001287460327},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.40400001406669617},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.3499999940395355},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5350000262260437},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.42399999499320984},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.4350000023841858},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.4230000078678131},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7152752876281738},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.4233739972114563},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3981376588344574},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3974374532699585},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.36716723442077637},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.3239072263240814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23583117127418518},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13837626576423645},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1271880865097046},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1242/dev.00860","doi":"https://doi.org/10.1242/dev.00860","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.00860","pdf_url":"https://journals.biologists.com/dev/article-pdf/130/23/5564/1498073/5564.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1242/dev.00860","doi":"https://doi.org/10.1242/dev.00860","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.00860","pdf_url":"https://journals.biologists.com/dev/article-pdf/130/23/5564/1498073/5564.pdf","source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000940741.pdf","grobid_xml":"https://content.openalex.org/works/W2000940741.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2586975375","https://openalex.org/W2477368224","https://openalex.org/W2077676720","https://openalex.org/W2006983051","https://openalex.org/W2060965624","https://openalex.org/W1500684751","https://openalex.org/W2279745110","https://openalex.org/W2127648317","https://openalex.org/W2802180361","https://openalex.org/W2025235733"],"abstract_inverted_index":{"Writing":[0],"a":[1,8,49,76,248,288,351,364,391,437,485,530,748,885,913,1058,1069,1173,1186,1222,1255,1320,1381,1418,1426,1452,1468,1486,1491,1518,1537,1554,1559],"textbook":[2,1487],"on":[3,79,94,104,367,585,831,899,1239],"developmental":[4,37,46,80,110,212,499,745,821,909,1066,1457,1472],"biology":[5,47,213,910,1067,1458,1688],"is,":[6],"today,":[7,663],"dangerous":[9,1492],"task.":[10],"The":[11,98,180,244,674,1188,1406,1578,1586],"amount":[12],"of":[13,45,52,73,100,161,178,184,191,211,224,306,316,346,350,355,370,423,447,481,487,498,505,523,543,589,618,624,632,645,657,670,711,721,736,743,793,808,817,820,837,854,872,887,893,908,957,961,971,973,975,977,980,1002,1010,1015,1057,1065,1099,1124,1127,1160,1167,1180,1190,1208,1236,1257,1275,1283,1290,1328,1371,1384,1433,1471,1510,1561,1580,1598,1616,1625,1636,1649,1654,1681,1684],"data":[14,1619],"being":[15,1219],"produced":[16],"in":[17,39,117,199,241,256,291,386,407,491,529,574,592,684,707,714,925,1080,1087,1170,1221,1254,1267,1281,1296,1357,1390,1398,1415,1620,1675],"labs":[18],"all":[19,61,196,234,1014,1653],"over":[20,1499],"the":[21,40,43,68,105,151,159,162,174,201,209,218,235,264,271,276,296,307,313,336,339,344,347,368,371,377,421,424,445,448,462,467,479,520,540,554,567,575,582,587,606,616,622,630,643,646,654,666,709,718,737,806,809,815,818,824,834,840,851,861,870,906,918,950,958,969,1032,1035,1054,1074,1078,1081,1088,1109,1122,1133,1149,1158,1165,1178,1199,1206,1225,1233,1244,1251,1273,1312,1318,1325,1332,1368,1372,1411,1430,1448,1571,1584,1613,1642,1650,1655,1663,1682,1687],"world":[22,522],"overwhelms":[23],"every":[24,36],"effort":[25,1674],"to":[26,29,32,35,64,84,92,130,139,146,269,295,326,338,343,402,457,493,586,678,699,701,726,752,770,779,911,953,987,1006,1013,1131,1154,1163,1175,1183,1265,1286,1324,1359,1402,1422,1460,1466,1477,1482,1566,1662,1686],"be":[27,33,1144,1301,1365,1423,1639],"up":[28],"date,":[30],"or":[31,979,1177],"fair":[34],"biologist":[38],"business.":[41],"Today,":[42],"study":[44],"entails":[48],"vast":[50],"array":[51,1009],"conceptual":[53],"frameworks,":[54],"methodologies":[55],"and":[56,71,102,137,155,157,166,204,220,299,341,379,389,411,420,431,433,444,453,460,475,501,514,526,550,557,563,566,580,599,601,610,621,650,659,688,740,755,790,797,856,866,902,935,945,1043,1090,1097,1120,1139,1201,1210,1238,1270,1341,1347,1356,1393,1438,1497,1502,1505,1547,1569,1596,1600,1630,1652],"exploration":[57],"tools,":[58],"making":[59,970],"it":[60,373,1152,1573,1632],"but":[62,773,1018,1037],"impossible":[63],"cover":[65,85],"ad":[66],"extenso":[67],"sources,":[69],"applications":[70],"directions":[72],"research.":[74,673],"As":[75],"result,":[77],"textbooks":[78],"biology,":[81,148,1292],"while":[82,237],"trying":[83],"as":[86,89,122,170,228,320,484,605,627,629,762,786,833,875,1051,1068,1151,1172,1232,1294,1515,1669,1671],"much":[87,311,774,804,1098,1314],"ground":[88],"possible,":[90],"have":[91,195,694,759,765,802,1612,1658],"focus":[93],"some":[95,260,1648],"specific":[96,340,879,1011],"issues.":[97,1000],"convergence":[99],"genetics":[101,136],"embryology":[103,138],"key":[106],"problems":[107,300],"faced":[108],"by":[109,281,547,724,1076],"biologists":[111,1473],"makes":[112],"both":[113],"disciplines":[114],"absolutely":[115],"necessary":[116],"an":[118,767,829,845,1008,1062,1329,1396,1508],"entry-level":[119],"book":[120,127,186,246,308,583,733,1150],"such":[121,169,785,1050,1293],"this":[123,185,638,731,763,1310,1462,1667,1677],"one.":[124],"A":[125],"winning":[126],"also":[128,801,1038],"has":[129,286,472,1105],"look":[131],"at":[132,150,642,814,1116,1303,1633,1641],"mechanisms":[133,569,623],"that":[134,207,258,301,383,560,570,848,857,877,956,1022,1071,1111,1121,1215,1260,1299,1363,1474,1563,1610],"bridge":[135,952],"show":[140],"how":[141,703,883,989,1031,1040,1410,1429,1565],"regulatory":[142,794],"gene":[143,395,795,1308,1321],"networks":[144,796],"relate":[145],"cell":[147,558,564,572,672,858,881,930,938,941,943,946,966,1085,1200,1268,1291,1297,1333],"hint":[149],"relationship":[152],"between":[153,164,864,1604],"development":[154,165,528,544,687,704,926,1119,1166,1217,1685],"evolution,":[156,715],"demonstrate":[158],"richness":[160],"interface":[163],"other":[167,503,841,1212],"sciences,":[168],"mathematical":[171,756,791],"modeling.This":[172],"is":[173,187,217,247,309,357,545,640,717,828,844,927,955,1027,1205,1249,1285,1311,1322,1377,1435,1490,1507,1558,1574],"case":[175],"with":[176,275,363,653,993,1073,1395,1592],"Principles":[177,354,1001,1635],"Development.":[179],"first":[181,252,272,1252],"striking":[182],"aspect":[183],"its":[188,317,488,1093,1095,1100,1202,1500],"impressive":[189,216],"list":[190,223],"authors":[192],"\u2013scientists":[193],"who":[194,322,777],"been":[197,473,695,760,1106,1659],"instrumental":[198],"shaping":[200],"basic":[202],"research":[203],"fundamental":[205,289,489],"findings":[206,262,739],"comprise":[208],"core":[210,1683],"today.":[214],"Equally":[215],"lengthy":[219],"astonishingly":[221],"authoritative":[222],"chapter":[225,639,676,750,1227],"editors,":[226,996],"although,":[227],"Lewis":[229,328,1672],"Wolpert":[230,868,1376],"admitted,":[231],"\u201cI":[232],"did":[233],"writing\u201d,":[236],"his":[238,994],"co-authors":[239],"were":[240],"\u201cpermanent":[242],"consultation\u201d.":[243],"present":[245,496],"second":[249],"edition":[250,253],"(the":[251],"was":[254,1531,1541,1552],"published":[255],"1998)":[257],"includes":[259],"crucial":[261,862,1288],"from":[263,335,1020,1045,1218,1307,1317,1367,1517],"past":[265],"five":[266],"years.":[267],"Needless":[268],"say,":[270],"edition,":[273],"along":[274,992],"now":[277],"classic":[278],"Developmental":[279],"Biology":[280],"Scott":[282],"Gilbert":[283],"(Sinauer":[284],"Associates),":[285],"played":[287],"role":[290,490],"introducing":[292],"college":[293,1576],"students":[294,702,776],"difficult":[297],"issues":[298,656,661,683,1387],"face":[302],"our":[303,495,891,897,1483],"science.The":[304],"structure":[305,590],"logical,":[310],"like":[312],"acute":[314],"mind":[315],"main":[318],"author,":[319],"those":[321,502,771,876],"are":[323,329,384,455,850,878,1023,1115,1388,1475,1588,1608],"lucky":[324],"enough":[325],"know":[327],"well":[330,628,1670],"aware.":[331],"It":[332,1204,1512],"moves":[333,584],"effortlessly":[334],"general":[337,741],"back":[342],"general,reminiscent":[345],"harmonious":[348],"deployment":[349],"Mahler":[352],"symphony.":[353],"Development":[356,1003,1026,1637],"divided":[358],"into":[359,376,394,440,539,781,1053,1425,1451],"15":[360,1241],"chapters.":[361],"Opening":[362],"short":[365,392],"history":[366],"beginnings":[369],"field,":[372],"then":[374,983,1494],"delves":[375],"vertebrate,invertebrate":[378],"plant":[380,527],"model":[381,465,1142],"systems":[382],"used":[385,723],"everyday":[387],"research,":[388],"provides":[390,860],"introduction":[393],"identification":[396],"protocols.":[397],"Next":[398],"come":[399],"chapters":[400],"dedicated":[401,751],"early":[403],"pattern":[404],"formation":[405,422,446,591,617,1141,1179,1327],"events":[406,443,634],"vertebrates(particularly":[408],"frogs,":[409],"chicks":[410],"mice);":[412],"Chapter":[413,434,482,517,613],"3":[414],"takes":[415],"us":[416,1514],"through":[417],"body":[418],"axes":[419],"three":[425],"metazoan":[426],"embryonic":[427,962,1276],"layers,":[428],"endoderm,":[429],"mesoderm":[430,441],"ectoderm,":[432],"4":[435],"digs":[436],"bit":[438],"deeper":[439],"patterning":[442],"neural":[449],"system.":[450,612],"Chapters":[451,548,578,648,1391],"5":[452,483,1524],"6":[454],"devoted":[456],"invertebrate":[458],"embryogenesis,":[459],"review":[461],"most":[463,735],"important":[464,655,920],"systems:":[466],"almighty":[468],"Drosophila":[469,1171],"melanogaster":[470],"(which":[471],"given,":[474],"no":[476],"doubt":[477],"deserves,":[478],"whole":[480,749,907,1449],"result":[486],"helping":[492],"attain":[494],"knowledge":[497,742,886],"processes)":[500],"heroes":[504],"experimental":[506],"lore,":[507],"nematode":[508,595],"worms,":[509],"sea":[510],"urchins,":[511],"ascidian":[512],"tunicates":[513],"slime":[515],"molds.":[516],"7":[518],"outlines":[519],"exciting":[521],"Arabidopsis":[524],"thaliana":[525],"concise,":[531],"albeit":[532],"very":[533,667,803],"pedagogic,":[534],"manner.FIG1An":[535],"excellent":[536,732],"entry":[537,768],"point":[538,769],"generic":[541,929,959],"processes":[542,556,1259,1401],"provided":[546,766],"8":[549,1392],"9,":[551,1394],"which":[552,716,1077],"discuss":[553],"morphogenetic":[555,1400],"dynamics":[559,799],"generate":[561],"form":[562],"differentiation,":[565],"molecular":[568,1369,1404],"underpin":[571],"specialization":[573],"embryo.":[576,1060],"In":[577],"10":[579],"11,":[581],"specifics":[588],"chick":[593],"limbs,the":[594],"vulva,":[596],"insect":[597],"wings":[598],"legs,":[600],"internal":[602],"vertebrate":[603],"organs,such":[604],"heart,":[607],"lungs,":[608],"kidneys":[609],"nervous":[611],"12":[614],"describes":[615],"germ":[619],"cells":[620,849,1162,1353],"sex":[625],"determination,":[626],"details":[631],"fertilization":[633],"(one":[635],"wonders":[636],"why":[637],"almost":[641,1601],"end":[644],"book!).":[647],"13":[649],"14":[651],"deal":[652,1383],"regeneration":[658],"growth,":[660,940],"that,":[662],"touch":[664],"upon":[665,1108,1194],"hot":[668],"topic":[669,692],"stem":[671],"closing":[675],"attempts":[677],"bring":[679,1478],"together":[680,1130,1355],"two":[681],"often-separated":[682],"modern":[685],"biology:":[686],"evolution.":[689],"However,this":[690],"last":[691,719],"could":[693,758],"covered":[696],"more":[697,1479],"extensively":[698],"explain":[700],"can":[705,984,1143,1628,1638],"help":[706],"explaining":[708],"origination":[710],"novel":[712],"features":[713],"bone":[720],"contention":[722],"creationists":[725],"criticize":[727],"evolutionary":[728],"theory.In":[729],"summary,":[730],"covers":[734],"recent":[738],"current":[744],"biology.":[746,822],"Perhaps":[747],"theoretical":[753],"concepts":[754],"modeling":[757,792],"added,":[761],"would":[764,800],"rare,":[772],"needed,":[775],"want":[778,1465],"venture":[780],"cross-disciplinary":[782],"roads.":[783],"Subjects":[784],"bioinformatics,":[787],"tissue":[788],"engineering,":[789],"cellular":[798,1258],"enriched":[805],"contents":[807],"book.An":[810],"interesting":[811],"paradox":[812],"lies":[813,1582],"heart":[816],"discipline":[819,1070],"On":[823,839],"one":[825],"hand,":[826,842],"there":[827,843,1557],"emphasis":[830,1397],"genes":[832,865,901,934,1079,1231,1284],"controlling":[835],"operators":[836],"development.":[838,867,1277],"explicit":[846,1063],"recognition":[847,1110],"actual":[852,1326],"`units":[853],"development'":[855],"behavior":[859,967,1086,1269],"link":[863],"introduces":[869],"concept":[871],"`luxury'":[873],"proteins":[874,889,903,936],"for":[880,1409,1428,1544],"types,but":[882],"does":[884,965],"these":[888,900,999,1016,1191,1209,1385,1488],"further":[890],"understanding":[892],"embryogenesis?":[894],"By":[895],"focusing":[896],"attention":[898],"we":[904,922,985,1242,1464],"reduce":[905],"`differentiation',":[912],"narrow":[914],"path":[915],"indeed.":[916],"Instead,":[917],"truly":[919],"question":[921],"must":[923,1315],"ask":[924],"about":[928,1030,1039,1456],"behavior.":[931],"How":[932,964],"do":[933],"affect":[937],"proliferation,cell":[939],"migration,":[942],"adhesion":[944],"death?":[947],"From":[948],"here,":[949],"next":[951],"cross":[954],"properties":[960],"tissues.":[963],"determine":[968,1092],"epithelia,":[972],"mesenchyme,":[974],"sheets,":[976],"tubes":[978],"vesicles?":[981],"Only":[982],"begin":[986],"understand":[988],"organisms":[990],"develop.Wolpert,":[991],"high-profile":[995],"certainly":[997],"recognizes":[998],"tries":[1004],"hard":[1005],"provide":[1007],"answers":[1012],"issues,":[1017],"sometimes":[1019],"questions":[1021],"too":[1024],"genocentric.":[1025],"not":[1028,1378],"only":[1029,1250,1280,1543,1553],"genotype":[1033],"controls":[1034],"phenotype,":[1036],"information":[1041,1048,1138,1413,1432],"deploys":[1042],"increases":[1044],"rather":[1046],"meager":[1047],"units,":[1049],"genes,":[1052],"rich":[1055,1545],"complexity":[1056,1128],"developing":[1059],"Despite":[1061],"definition":[1064],"\u201cdeals":[1072],"process":[1075],"fertilized":[1082],"egg":[1083],"control":[1084],"embryo":[1089],"so":[1091,1271],"pattern,":[1094],"form,":[1096],"behavior\u201d,":[1101],"Wolpert's":[1102,1136,1673],"scientific":[1103],"career":[1104],"built":[1107],"many":[1112,1195,1211,1304],"interacting":[1113,1196],"forces":[1114],"play":[1117],"during":[1118],"emergence":[1123],"new":[1125,1469],"levels":[1126,1443],"act":[1129,1354,1509],"shape":[1132],"organism.For":[1134],"example,":[1135],"positional":[1137],"gradient":[1140],"found":[1145],"several":[1146],"times":[1147],"throughout":[1148],"applies":[1153],"different":[1155,1605],"scenarios":[1156],"(e.g.":[1157],"response":[1159,1174],"ectodermal":[1161],"activin,":[1164],"anterior":[1168],"structures":[1169],"bicoid,":[1176],"compartment":[1181],"boundaries,":[1182],"mention":[1184],"just":[1185],"few).":[1187],"establishment":[1189],"gradients":[1192],"depends":[1193],"factors":[1197],"involving":[1198],"environment.":[1203],"appearance":[1207],"complex":[1213,1337],"interactions":[1214,1335,1370],"prevents":[1216],"treated":[1220],"genotype-specifies-phenotype":[1223],"fashion.Thus,":[1224],"introductory":[1226],"warns":[1228],"against":[1229],"taking":[1230],"ultimate":[1234],"cause":[1235],"development,":[1237],"page":[1240],"find":[1243],"following":[1245],"illuminating":[1246],"comment:\u201c...gene":[1247],"expression":[1248],"step":[1253],"cascade":[1256],"lead":[1261],"via":[1262],"protein":[1263],"synthesis":[1264],"changes":[1266],"direct":[1272],"course":[1274],"To":[1278],"think":[1279],"terms":[1282],"ignore":[1287],"aspects":[1289],"change":[1295],"shape,":[1298],"may":[1300],"initiated":[1302],"steps":[1305],"removed":[1306],"activity.\u201dIndeed":[1309],"case:":[1313],"happen":[1316],"moment":[1319],"expressed":[1323],"organ.":[1330],"Inside":[1331],"cytoplasm,molecular":[1334],"exhibit":[1336,1360],"dynamics,":[1338],"including":[1339],"positive":[1340],"negative":[1342],"feedback":[1343],"loops,":[1344],"oscillatory":[1345],"phenomena":[1346],"cooperative":[1348],"enzymatic":[1349],"actions.":[1350],"Most":[1351],"importantly,":[1352],"coordination":[1358],"emergent":[1361],"behaviors":[1362],"cannot":[1364],"deduced":[1366],"individual":[1373],"cells.":[1374],"Again,":[1375],"taken":[1379],"off-guard,":[1380],"great":[1382],"fascinating":[1386],"delivered":[1389],"linking":[1399],"intracellular":[1403],"interactions.":[1405],"old":[1407],"search":[1408,1427],"linear":[1412,1431],"encoded":[1414],"DNA":[1416,1434],"specifies":[1417],"three-dimensional":[1419,1453,1594],"organism":[1420],"needs":[1421],"transformed":[1424],"translated,":[1436],"reprocessed":[1437],"spatio-temporally":[1439],"deployed":[1440],"across":[1441],"network":[1442],"(molecules,":[1444],"cells,":[1445],"tissues,":[1446],"organs,":[1447],"embryo)":[1450],"organism.":[1454],"Textbooks":[1455],"need":[1459],"emphasize":[1461],"if":[1463],"educate":[1467],"generation":[1470],"able":[1476],"integrative":[1480],"views":[1481],"science.If":[1484],"writing":[1485],"days":[1489],"task,":[1493],"reading":[1495],"it,":[1496],"poring":[1498],"sections":[1501],"subsections,":[1503],"headings":[1504],"definitions":[1506],"love.":[1511],"strikes":[1513],"something":[1516],"past,":[1519],"romantic":[1520],"era":[1521],"\u2013":[1522,1527],"hardly":[1523],"years":[1525],"ago":[1526],"when":[1528,1534,1548],"RAM":[1529],"memory":[1530],"still":[1532],"expensive,":[1533],"bringing":[1535,1676],"home":[1536],"1":[1538],"Ghz":[1539],"computer":[1540],"possible":[1542],"students,":[1546],"high-speed":[1549],"Internet":[1550],"access":[1551],"dream.":[1555],"If":[1556],"class":[1560],"people":[1562],"knows":[1564],"use":[1567,1631],"computers":[1568],"browse":[1570],"Internet,":[1572],"undoubtedly":[1575],"students.":[1577],"future":[1579],"academia":[1581],"within":[1583],"Internet.":[1585],"possibilities":[1587],"endless:simulations,":[1589],"virtual":[1590,1593],"rooms":[1591],"reconstructions,pages":[1595],"pages":[1597],"illustrations,":[1599],"infinite":[1602],"cross-hyperlinks":[1603],"sources.":[1606],"We":[1607,1665],"sure":[1609],"publishers":[1611],"same":[1614],"vision":[1615],"gathering":[1617],"academic":[1618],"places":[1621],"where":[1622,1647],"everyone,":[1623],"regardless":[1624],"geographic":[1626],"situation,":[1627],"visit":[1629],"leisure.Indeed,":[1634],"visited":[1640],"Oxford":[1643],"University":[1644],"Press":[1645],"website,":[1646],"text":[1651],"book's":[1656],"pictures":[1657],"made":[1660],"available":[1661],"public.":[1664],"welcome":[1666],"initiative":[1668],"unique":[1678],"updated":[1679],"version":[1680],"classroom.":[1689]},"counts_by_year":[],"updated_date":"2026-09-05T08:02:43.246662","created_date":"2016-06-24T00:00:00"}